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Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata.
Int J Biol Macromol. 2004 Apr; 34(1-2):63-71.IJ

Abstract

This study presents the chemical composition and antiviral activity against herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) of sulfated galactan crude extracts and main fractions obtained from two red seaweeds collected in Brazil, Gymnogongrus griffithsiae and Cryptonemia crenulata. Most of the eighteen tested products, including homogeneous kappa/iota/nu carrageenan and DL-galactan hybrid, exhibited antiherpetic activity with inhibitory concentration 50% (IC50) values in the range 0.5-5.6 microg/ml, as determined in a virus plaque reduction assay in Vero cells. The galactans lacked cytotoxic effects and showed a broad spectrum of antiviral activity against HSV-1 and HSV-2. No direct virus inactivation was observed after virion treatment with the galactans. The mode of action of these compounds could be mainly ascribed to an inhibitory effect on virus adsorption. Most importantly, a significant protection against a murine vaginal infection with HSV-2 was afforded by topical treatment with the sulfated galactans.

Authors+Show Affiliations

Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, 1428 Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15178011

Citation

Talarico, Laura B., et al. "Anti-herpes Simplex Virus Activity of Sulfated Galactans From the Red Seaweeds Gymnogongrus Griffithsiae and Cryptonemia Crenulata." International Journal of Biological Macromolecules, vol. 34, no. 1-2, 2004, pp. 63-71.
Talarico LB, Zibetti RG, Faria PC, et al. Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata. Int J Biol Macromol. 2004;34(1-2):63-71.
Talarico, L. B., Zibetti, R. G., Faria, P. C., Scolaro, L. A., Duarte, M. E., Noseda, M. D., Pujol, C. A., & Damonte, E. B. (2004). Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata. International Journal of Biological Macromolecules, 34(1-2), 63-71.
Talarico LB, et al. Anti-herpes Simplex Virus Activity of Sulfated Galactans From the Red Seaweeds Gymnogongrus Griffithsiae and Cryptonemia Crenulata. Int J Biol Macromol. 2004;34(1-2):63-71. PubMed PMID: 15178011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata. AU - Talarico,Laura B, AU - Zibetti,Rosiane G M, AU - Faria,Paula C S, AU - Scolaro,Luis A, AU - Duarte,Maria E R, AU - Noseda,Miguel D, AU - Pujol,Carlos A, AU - Damonte,Elsa B, PY - 2004/6/5/pubmed PY - 2005/2/8/medline PY - 2004/6/5/entrez SP - 63 EP - 71 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 34 IS - 1-2 N2 - This study presents the chemical composition and antiviral activity against herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) of sulfated galactan crude extracts and main fractions obtained from two red seaweeds collected in Brazil, Gymnogongrus griffithsiae and Cryptonemia crenulata. Most of the eighteen tested products, including homogeneous kappa/iota/nu carrageenan and DL-galactan hybrid, exhibited antiherpetic activity with inhibitory concentration 50% (IC50) values in the range 0.5-5.6 microg/ml, as determined in a virus plaque reduction assay in Vero cells. The galactans lacked cytotoxic effects and showed a broad spectrum of antiviral activity against HSV-1 and HSV-2. No direct virus inactivation was observed after virion treatment with the galactans. The mode of action of these compounds could be mainly ascribed to an inhibitory effect on virus adsorption. Most importantly, a significant protection against a murine vaginal infection with HSV-2 was afforded by topical treatment with the sulfated galactans. SN - 0141-8130 UR - https://www.unboundmedicine.com/medline/citation/15178011/Anti_herpes_simplex_virus_activity_of_sulfated_galactans_from_the_red_seaweeds_Gymnogongrus_griffithsiae_and_Cryptonemia_crenulata_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S014181300400008X DB - PRIME DP - Unbound Medicine ER -