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IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.
Arterioscler Thromb Vasc Biol 2004; 24(8):1503-8AT

Abstract

OBJECTIVE

To study the role of IL-8 in predicting future coronary artery disease (CAD) in apparently healthy men and women.

METHODS AND RESULTS

A nested case-control study was performed in the prospective EPIC-Norfolk population study. We measured baseline IL-8 concentrations among 785 apparently healthy individuals in whom fatal or nonfatal CAD developed during follow-up and 1570 matched controls. Baseline IL-8 concentrations were higher in cases than in matched controls (3.5 pg/mL versus 3.1 pg/mL, P=0.001). The risk of future CAD increased with increasing quartiles of IL-8 (P linearity <0.0001). Among individuals in the highest IL-8 quartile, the unadjusted odds ratio for future CAD was 1.72 (95% CI, 1.34 to 2.21; P<0.0001). The odds ratio for future CAD was still significant after adjustment for traditional risk factors (OR, 1.58; 95%CI, 1.19 to 2.09; P=0.002) and after additional adjustment for C-reactive protein and white cell count (OR, 1.77; 95% CI, 1.21 to 2.60; P=0.001).

CONCLUSIONS

We conclude that among apparently healthy men and women, elevated levels of IL-8 are associated with an increased risk of future CAD. These prospective data support a role for IL-8 in the development of CAD events.

Authors+Show Affiliations

Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15178568

Citation

Boekholdt, S Matthijs, et al. "IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women: the EPIC-Norfolk Prospective Population Study." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 8, 2004, pp. 1503-8.
Boekholdt SM, Peters RJ, Hack CE, et al. IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study. Arterioscler Thromb Vasc Biol. 2004;24(8):1503-8.
Boekholdt, S. M., Peters, R. J., Hack, C. E., Day, N. E., Luben, R., Bingham, S. A., ... Khaw, K. T. (2004). IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(8), pp. 1503-8.
Boekholdt SM, et al. IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women: the EPIC-Norfolk Prospective Population Study. Arterioscler Thromb Vasc Biol. 2004;24(8):1503-8. PubMed PMID: 15178568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study. AU - Boekholdt,S Matthijs, AU - Peters,Ron J G, AU - Hack,C Erik, AU - Day,Nicholas E, AU - Luben,Robert, AU - Bingham,Sheila A, AU - Wareham,Nicholas J, AU - Reitsma,Pieter H, AU - Khaw,Kay-Tee, Y1 - 2004/06/03/ PY - 2004/6/5/pubmed PY - 2005/2/11/medline PY - 2004/6/5/entrez SP - 1503 EP - 8 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 24 IS - 8 N2 - OBJECTIVE: To study the role of IL-8 in predicting future coronary artery disease (CAD) in apparently healthy men and women. METHODS AND RESULTS: A nested case-control study was performed in the prospective EPIC-Norfolk population study. We measured baseline IL-8 concentrations among 785 apparently healthy individuals in whom fatal or nonfatal CAD developed during follow-up and 1570 matched controls. Baseline IL-8 concentrations were higher in cases than in matched controls (3.5 pg/mL versus 3.1 pg/mL, P=0.001). The risk of future CAD increased with increasing quartiles of IL-8 (P linearity <0.0001). Among individuals in the highest IL-8 quartile, the unadjusted odds ratio for future CAD was 1.72 (95% CI, 1.34 to 2.21; P<0.0001). The odds ratio for future CAD was still significant after adjustment for traditional risk factors (OR, 1.58; 95%CI, 1.19 to 2.09; P=0.002) and after additional adjustment for C-reactive protein and white cell count (OR, 1.77; 95% CI, 1.21 to 2.60; P=0.001). CONCLUSIONS: We conclude that among apparently healthy men and women, elevated levels of IL-8 are associated with an increased risk of future CAD. These prospective data support a role for IL-8 in the development of CAD events. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/15178568/IL_8_plasma_concentrations_and_the_risk_of_future_coronary_artery_disease_in_apparently_healthy_men_and_women:_the_EPIC_Norfolk_prospective_population_study_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.ATV.0000134294.54422.2e?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -