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Serum uric acid and risk of death from cancer, cardiovascular disease or all causes in men.
Eur J Cardiovasc Prev Rehabil 2004; 11(3):185-91EJ

Abstract

OBJECTIVE

Although many epidemiological studies have suggested that increased serum uric acid levels are a risk factor for mortality, this relationship remains uncertain. This cohort study examined the effects of serum uric acid level on death from cancer, atherosclerotic cardiovascular disease (ASCVD) or all causes in men.

METHOD

A 9-year, prospective cohort study was carried out with 22698 Korean men, aged 30 to 77 years, who received health insurance from the National Health Insurance Corporation and who underwent biennial, secondary medical evaluations in 1992-1996. The main outcome measures were death from cancer, ASCVD or all causes, compared by quintiles of serum uric acid level. At baseline, the mean (SD) level of serum uric acid was 354.4 (98.1) micromol/l.

RESULTS

During 199746 person-years of follow-up, there were 387 cancer deaths, 323 ASCVD (99 ischaemic heart disease, 192 stroke) deaths and 1625 all-cause deaths. In multivariate Cox proportional hazards models, having controlled for age, current smoking, diabetes, hypertension and hypercholesterolaemia, uric acid levels were not associated with mortality from cancer, ASCVD or all causes. However, for those with diabetes, uric acid levels were associated with mortality from all causes even after full adjustment of the covariates. When the interaction term was included in the multivariate model, there was significant interactive effect of uric acid with diabetes (RR=1.26, 95% confidence interval 1.02-1.55) on the risk of all cause of death, whereas the effects of uric acid itself did not attain significance.

CONCLUSION

These findings indicate that uric acid level is not an independent risk factor for death from cancer, ASCVD or all causes.

Authors+Show Affiliations

Department of Epidemiology and Health Promotion, Graduate School of Public Health, The Yonsei University, PO Box 8044, Seoul 120-749, Korea. jsunha@yumc.yonsei.ac.krNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15179098

Citation

Jee, Sun Ha, et al. "Serum Uric Acid and Risk of Death From Cancer, Cardiovascular Disease or All Causes in Men." European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, vol. 11, no. 3, 2004, pp. 185-91.
Jee SH, Lee SY, Kim MT. Serum uric acid and risk of death from cancer, cardiovascular disease or all causes in men. Eur J Cardiovasc Prev Rehabil. 2004;11(3):185-91.
Jee, S. H., Lee, S. Y., & Kim, M. T. (2004). Serum uric acid and risk of death from cancer, cardiovascular disease or all causes in men. European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 11(3), pp. 185-91.
Jee SH, Lee SY, Kim MT. Serum Uric Acid and Risk of Death From Cancer, Cardiovascular Disease or All Causes in Men. Eur J Cardiovasc Prev Rehabil. 2004;11(3):185-91. PubMed PMID: 15179098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum uric acid and risk of death from cancer, cardiovascular disease or all causes in men. AU - Jee,Sun Ha, AU - Lee,Soon Young, AU - Kim,Miyong T, PY - 2004/6/5/pubmed PY - 2004/12/22/medline PY - 2004/6/5/entrez SP - 185 EP - 91 JF - European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology JO - Eur J Cardiovasc Prev Rehabil VL - 11 IS - 3 N2 - OBJECTIVE: Although many epidemiological studies have suggested that increased serum uric acid levels are a risk factor for mortality, this relationship remains uncertain. This cohort study examined the effects of serum uric acid level on death from cancer, atherosclerotic cardiovascular disease (ASCVD) or all causes in men. METHOD: A 9-year, prospective cohort study was carried out with 22698 Korean men, aged 30 to 77 years, who received health insurance from the National Health Insurance Corporation and who underwent biennial, secondary medical evaluations in 1992-1996. The main outcome measures were death from cancer, ASCVD or all causes, compared by quintiles of serum uric acid level. At baseline, the mean (SD) level of serum uric acid was 354.4 (98.1) micromol/l. RESULTS: During 199746 person-years of follow-up, there were 387 cancer deaths, 323 ASCVD (99 ischaemic heart disease, 192 stroke) deaths and 1625 all-cause deaths. In multivariate Cox proportional hazards models, having controlled for age, current smoking, diabetes, hypertension and hypercholesterolaemia, uric acid levels were not associated with mortality from cancer, ASCVD or all causes. However, for those with diabetes, uric acid levels were associated with mortality from all causes even after full adjustment of the covariates. When the interaction term was included in the multivariate model, there was significant interactive effect of uric acid with diabetes (RR=1.26, 95% confidence interval 1.02-1.55) on the risk of all cause of death, whereas the effects of uric acid itself did not attain significance. CONCLUSION: These findings indicate that uric acid level is not an independent risk factor for death from cancer, ASCVD or all causes. SN - 1741-8267 UR - https://www.unboundmedicine.com/medline/citation/15179098/Serum_uric_acid_and_risk_of_death_from_cancer_cardiovascular_disease_or_all_causes_in_men_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15179098.ui DB - PRIME DP - Unbound Medicine ER -