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The efficacy of therapy with albendazole in mice with parasitic meningitis caused by Angiostrongylus cantonensis.
Parasitol Res. 2004 Jul; 93(4):311-7.PR

Abstract

Matrix metalloproteinase 9 (MMP-9) is involved in the pathogenesis of parasitic meningitis caused by the nematode Angiostrongylus cantonensis. The present study evaluated the efficacy of albendazole therapy in BALB/c mice infected with the third stage larvae of this nematode. Albendazole showed a pronounced larvicidal activity. Eosinophil numbers significantly increased in infected mice but decreased upon administration of albendazole. Densitometric scanning indicated that albendazole reduced gelatinolytic activity detected by gelatin-substrate zymography. In the cerebrospinal fluid, albendazole reduced the lytic area intensity of the 94 kDa MMP-9 band by 46.5% within 7 days, and by 51.5% by day 14. Examination of brain tissue revealed a similar pattern of decrease (48.6% by day 7, and 53.9% by day 14). Albendazole may thus be an effective compound for the treatment of angiostrongyliasis through its larvicidal activity and facilitation of an improved inflammatory response via the reduction of MMP-9 activity.

Authors+Show Affiliations

Institute of Biochemistry, Chung Shan Medical University, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15179507

Citation

Lan, K P., et al. "The Efficacy of Therapy With Albendazole in Mice With Parasitic Meningitis Caused By Angiostrongylus Cantonensis." Parasitology Research, vol. 93, no. 4, 2004, pp. 311-7.
Lan KP, Wang CJ, Lai SC, et al. The efficacy of therapy with albendazole in mice with parasitic meningitis caused by Angiostrongylus cantonensis. Parasitol Res. 2004;93(4):311-7.
Lan, K. P., Wang, C. J., Lai, S. C., Chen, K. M., Lee, S. S., Hsu, J. D., & Lee, H. H. (2004). The efficacy of therapy with albendazole in mice with parasitic meningitis caused by Angiostrongylus cantonensis. Parasitology Research, 93(4), 311-7.
Lan KP, et al. The Efficacy of Therapy With Albendazole in Mice With Parasitic Meningitis Caused By Angiostrongylus Cantonensis. Parasitol Res. 2004;93(4):311-7. PubMed PMID: 15179507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The efficacy of therapy with albendazole in mice with parasitic meningitis caused by Angiostrongylus cantonensis. AU - Lan,K P, AU - Wang,C J, AU - Lai,S C, AU - Chen,K M, AU - Lee,S S, AU - Hsu,J D, AU - Lee,H H, Y1 - 2004/06/04/ PY - 2003/09/30/received PY - 2004/02/23/accepted PY - 2004/6/5/pubmed PY - 2004/9/15/medline PY - 2004/6/5/entrez SP - 311 EP - 7 JF - Parasitology research JO - Parasitol Res VL - 93 IS - 4 N2 - Matrix metalloproteinase 9 (MMP-9) is involved in the pathogenesis of parasitic meningitis caused by the nematode Angiostrongylus cantonensis. The present study evaluated the efficacy of albendazole therapy in BALB/c mice infected with the third stage larvae of this nematode. Albendazole showed a pronounced larvicidal activity. Eosinophil numbers significantly increased in infected mice but decreased upon administration of albendazole. Densitometric scanning indicated that albendazole reduced gelatinolytic activity detected by gelatin-substrate zymography. In the cerebrospinal fluid, albendazole reduced the lytic area intensity of the 94 kDa MMP-9 band by 46.5% within 7 days, and by 51.5% by day 14. Examination of brain tissue revealed a similar pattern of decrease (48.6% by day 7, and 53.9% by day 14). Albendazole may thus be an effective compound for the treatment of angiostrongyliasis through its larvicidal activity and facilitation of an improved inflammatory response via the reduction of MMP-9 activity. SN - 0932-0113 UR - https://www.unboundmedicine.com/medline/citation/15179507/The_efficacy_of_therapy_with_albendazole_in_mice_with_parasitic_meningitis_caused_by_Angiostrongylus_cantonensis_ L2 - https://dx.doi.org/10.1007/s00436-004-1105-9 DB - PRIME DP - Unbound Medicine ER -