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Flavonol and flavone intake and the risk of intermittent claudication in male smokers.
Eur J Epidemiol. 2004; 19(4):305-11.EJ

Abstract

The objective of this study was to investigate the association between flavonol and flavone intake and the risk of intermittent claudication in male smokers. The study population consisted of participants of the Finnish alpha-Tocopherol, beta-Carotene Cancer Prevention (ATBC) Study, who were free of intermittent claudication at study entry. These 25,041 male smokers were 50-69 years old at baseline. Participants completed a validated dietary questionnaire at baseline. The occurrence of intermittent claudication was assessed by annual administration of the Rose questionnaire. During the median follow-up of 4.1 years, 2412 new cases of intermittent claudication were observed. Dietary intake of flavonols and flavones was inversely associated with the risk of intermittent claudication when adjusted for cardiovascular risk factors (relative risk, RR in the highest vs. lowest quintile of intake 0.86, 95% confidence interval, CI: 0.75-0.98, p for trend 0.007). However, after further adjustment for intakes of vitamins C and E and total carotenoids, the association was attenuated (RR: 0.93, 95% CI: 0.81-1.08, p for trend 0.12). The risk of intermittent claudication was lower among men in the highest quintile of vegetable consumption (RR: 0.78, 95% CI: 0.69-0.89, p for trend 0.0001) and among wine drinkers (RR: 0.63, 95% CI: 0.41-0.98). Adjustment for flavonol and flavone intake only marginally changed these associations. In conclusion, flavonol and flavone intake was not independently associated with the risk of intermittent claudication.

Authors+Show Affiliations

Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland. tero.hirvonen@ktl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15180100

Citation

Hirvonen, Tero, et al. "Flavonol and Flavone Intake and the Risk of Intermittent Claudication in Male Smokers." European Journal of Epidemiology, vol. 19, no. 4, 2004, pp. 305-11.
Hirvonen T, Törnwall ME, Pietinen P, et al. Flavonol and flavone intake and the risk of intermittent claudication in male smokers. Eur J Epidemiol. 2004;19(4):305-11.
Hirvonen, T., Törnwall, M. E., Pietinen, P., Korhonen, P., Albanes, D., & Virtamo, J. (2004). Flavonol and flavone intake and the risk of intermittent claudication in male smokers. European Journal of Epidemiology, 19(4), 305-11.
Hirvonen T, et al. Flavonol and Flavone Intake and the Risk of Intermittent Claudication in Male Smokers. Eur J Epidemiol. 2004;19(4):305-11. PubMed PMID: 15180100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonol and flavone intake and the risk of intermittent claudication in male smokers. AU - Hirvonen,Tero, AU - Törnwall,Markareetta E, AU - Pietinen,Pirjo, AU - Korhonen,Pasi, AU - Albanes,Demetrius, AU - Virtamo,Jarmo, PY - 2004/6/8/pubmed PY - 2004/8/10/medline PY - 2004/6/8/entrez SP - 305 EP - 11 JF - European journal of epidemiology JO - Eur. J. Epidemiol. VL - 19 IS - 4 N2 - The objective of this study was to investigate the association between flavonol and flavone intake and the risk of intermittent claudication in male smokers. The study population consisted of participants of the Finnish alpha-Tocopherol, beta-Carotene Cancer Prevention (ATBC) Study, who were free of intermittent claudication at study entry. These 25,041 male smokers were 50-69 years old at baseline. Participants completed a validated dietary questionnaire at baseline. The occurrence of intermittent claudication was assessed by annual administration of the Rose questionnaire. During the median follow-up of 4.1 years, 2412 new cases of intermittent claudication were observed. Dietary intake of flavonols and flavones was inversely associated with the risk of intermittent claudication when adjusted for cardiovascular risk factors (relative risk, RR in the highest vs. lowest quintile of intake 0.86, 95% confidence interval, CI: 0.75-0.98, p for trend 0.007). However, after further adjustment for intakes of vitamins C and E and total carotenoids, the association was attenuated (RR: 0.93, 95% CI: 0.81-1.08, p for trend 0.12). The risk of intermittent claudication was lower among men in the highest quintile of vegetable consumption (RR: 0.78, 95% CI: 0.69-0.89, p for trend 0.0001) and among wine drinkers (RR: 0.63, 95% CI: 0.41-0.98). Adjustment for flavonol and flavone intake only marginally changed these associations. In conclusion, flavonol and flavone intake was not independently associated with the risk of intermittent claudication. SN - 0393-2990 UR - https://www.unboundmedicine.com/medline/citation/15180100/Flavonol_and_flavone_intake_and_the_risk_of_intermittent_claudication_in_male_smokers_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15180100.ui DB - PRIME DP - Unbound Medicine ER -