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Impact of coexisting irritable bowel syndrome on symptoms and pathophysiological mechanisms in functional dyspepsia.
Am J Gastroenterol. 2004 Jun; 99(6):1152-9.AJ

Abstract

Epidemiological studies suggest considerable overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS).

AIM

The aim of the present study was to investigate whether coexisting IBS is also associated with symptom pattern or pathophysiology in FD.

METHODS

In 309 consecutive FD patients (207 women, age 42 +/- 0.8 yr), questionnaires were used to assess the dyspepsia symptom pattern and the Rome II criteria for IBS. The overall symptom severity was calculated adding the severity score (0-3, 0 = absent, 3 = severe) of eight dyspepsia symptoms. All patients underwent Helicobacter pylori testing, gastric barostat to determine sensitivity to distention and accommodation to a meal, and gastric emptying breath test.

RESULTS

Fifty-four percent of the patients had FD alone, whereas 46% had FD + IBS. FD + IBS patients were more likely to be female (75%vs 60%, p < 0.01) and to have a greater weight loss (5.4 +/- 0.6 vs 3.5 +/- 0.4 kg, p < 0.05). Coexisting IBS did not increase the risk of having any of the dyspeptic symptoms but the overall symptom severity was significantly higher in FD + IBS (12.4 +/- 0.4 vs 9.8 +/- 0.3, p < 0.01). FD + IBS patients had a lower threshold for first perception (2.9 +/- 0.3 vs 3.8 +/- 0.3 mmHg, p < 0.05) and for discomfort (7.9 +/- 0.4 vs 9.5 +/- 0.5 mmHg, p < 0.05) and a greater prevalence of hypersensitivity to gastric distention (44%vs 28%, p < 0.05). Gastric emptying, accommodation to a meal, and prevalence of H. pylori infection did not differ in the two groups.

CONCLUSION

About half of the FD patients fulfill the Rome II criteria for IBS. FD + IBS is more prevalent in female patients and is associated with a higher weight loss, with greater overall symptom severity, and with hypersensitivity to distention.

Authors+Show Affiliations

Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15180740

Citation

Corsetti, Maura, et al. "Impact of Coexisting Irritable Bowel Syndrome On Symptoms and Pathophysiological Mechanisms in Functional Dyspepsia." The American Journal of Gastroenterology, vol. 99, no. 6, 2004, pp. 1152-9.
Corsetti M, Caenepeel P, Fischler B, et al. Impact of coexisting irritable bowel syndrome on symptoms and pathophysiological mechanisms in functional dyspepsia. Am J Gastroenterol. 2004;99(6):1152-9.
Corsetti, M., Caenepeel, P., Fischler, B., Janssens, J., & Tack, J. (2004). Impact of coexisting irritable bowel syndrome on symptoms and pathophysiological mechanisms in functional dyspepsia. The American Journal of Gastroenterology, 99(6), 1152-9.
Corsetti M, et al. Impact of Coexisting Irritable Bowel Syndrome On Symptoms and Pathophysiological Mechanisms in Functional Dyspepsia. Am J Gastroenterol. 2004;99(6):1152-9. PubMed PMID: 15180740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of coexisting irritable bowel syndrome on symptoms and pathophysiological mechanisms in functional dyspepsia. AU - Corsetti,Maura, AU - Caenepeel,Philip, AU - Fischler,Benjamin, AU - Janssens,Jozef, AU - Tack,Jan, PY - 2004/6/8/pubmed PY - 2004/8/7/medline PY - 2004/6/8/entrez SP - 1152 EP - 9 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 99 IS - 6 N2 - UNLABELLED: Epidemiological studies suggest considerable overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS). AIM: The aim of the present study was to investigate whether coexisting IBS is also associated with symptom pattern or pathophysiology in FD. METHODS: In 309 consecutive FD patients (207 women, age 42 +/- 0.8 yr), questionnaires were used to assess the dyspepsia symptom pattern and the Rome II criteria for IBS. The overall symptom severity was calculated adding the severity score (0-3, 0 = absent, 3 = severe) of eight dyspepsia symptoms. All patients underwent Helicobacter pylori testing, gastric barostat to determine sensitivity to distention and accommodation to a meal, and gastric emptying breath test. RESULTS: Fifty-four percent of the patients had FD alone, whereas 46% had FD + IBS. FD + IBS patients were more likely to be female (75%vs 60%, p < 0.01) and to have a greater weight loss (5.4 +/- 0.6 vs 3.5 +/- 0.4 kg, p < 0.05). Coexisting IBS did not increase the risk of having any of the dyspeptic symptoms but the overall symptom severity was significantly higher in FD + IBS (12.4 +/- 0.4 vs 9.8 +/- 0.3, p < 0.01). FD + IBS patients had a lower threshold for first perception (2.9 +/- 0.3 vs 3.8 +/- 0.3 mmHg, p < 0.05) and for discomfort (7.9 +/- 0.4 vs 9.5 +/- 0.5 mmHg, p < 0.05) and a greater prevalence of hypersensitivity to gastric distention (44%vs 28%, p < 0.05). Gastric emptying, accommodation to a meal, and prevalence of H. pylori infection did not differ in the two groups. CONCLUSION: About half of the FD patients fulfill the Rome II criteria for IBS. FD + IBS is more prevalent in female patients and is associated with a higher weight loss, with greater overall symptom severity, and with hypersensitivity to distention. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/15180740/Impact_of_coexisting_irritable_bowel_syndrome_on_symptoms_and_pathophysiological_mechanisms_in_functional_dyspepsia_ L2 - http://Insights.ovid.com/pubmed?pmid=15180740 DB - PRIME DP - Unbound Medicine ER -