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Combination of ziprasidone and clozapine in treatment-resistant schizophrenia.
Hum Psychopharmacol. 2004 Jun; 19(4):271-3.HP

Abstract

In cases of treatment-resistant schizophrenia the combined application of antipsychotic drugs often becomes necessary. Clozapine has been combined successfully with other atypical antipsychotic drugs such as risperidone or amisulpride in the past. We report the difficult treatment of a 28-year-old schizophrenic woman. Psychotic symptoms were found resistant to monotherapy with clozapine or ziprasidone. In contrast, combined application led to a marked improvement in both positive and negative symptoms of schizophrenia along with a decrease of side effects.The reported combination is a promising option in cases of treatment-resistant schizophrenia and should be further evaluated in prospective studies.

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Authors+Show Affiliations

Zink M
Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany. zink@kv.zi-mannheim.de
Mase E
No affiliation info available
Dressing H
No affiliation info available

MeSH

AdultAntipsychotic AgentsClozapineDrug ResistanceDrug Therapy, CombinationFemaleHumansPiperazinesSchizophreniaThiazolesTreatment Outcome

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15181656

Citation

Zink, M, et al. "Combination of Ziprasidone and Clozapine in Treatment-resistant Schizophrenia." Human Psychopharmacology, vol. 19, no. 4, 2004, pp. 271-3.
Zink M, Mase E, Dressing H. Combination of ziprasidone and clozapine in treatment-resistant schizophrenia. Hum Psychopharmacol. 2004;19(4):271-3.
Zink, M., Mase, E., & Dressing, H. (2004). Combination of ziprasidone and clozapine in treatment-resistant schizophrenia. Human Psychopharmacology, 19(4), 271-3.
Zink M, Mase E, Dressing H. Combination of Ziprasidone and Clozapine in Treatment-resistant Schizophrenia. Hum Psychopharmacol. 2004;19(4):271-3. PubMed PMID: 15181656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination of ziprasidone and clozapine in treatment-resistant schizophrenia. AU - Zink,M, AU - Mase,E, AU - Dressing,H, PY - 2004/6/8/pubmed PY - 2004/12/16/medline PY - 2004/6/8/entrez SP - 271 EP - 3 JF - Human psychopharmacology JO - Hum Psychopharmacol VL - 19 IS - 4 N2 - In cases of treatment-resistant schizophrenia the combined application of antipsychotic drugs often becomes necessary. Clozapine has been combined successfully with other atypical antipsychotic drugs such as risperidone or amisulpride in the past. We report the difficult treatment of a 28-year-old schizophrenic woman. Psychotic symptoms were found resistant to monotherapy with clozapine or ziprasidone. In contrast, combined application led to a marked improvement in both positive and negative symptoms of schizophrenia along with a decrease of side effects.The reported combination is a promising option in cases of treatment-resistant schizophrenia and should be further evaluated in prospective studies. SN - 0885-6222 UR - https://www.unboundmedicine.com/medline/citation/15181656/Combination_of_ziprasidone_and_clozapine_in_treatment_resistant_schizophrenia_ L2 - https://doi.org/10.1002/hup.580 DB - PRIME DP - Unbound Medicine ER -