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Effect of a methionine-supplemented diet on the blood pressure of Sprague-Dawley and deoxycorticosterone acetate-salt hypertensive rats.
Br J Nutr. 2004 Jun; 91(6):857-65.BJ

Abstract

The objectives of the present study were to evaluate the effects of a methionine-supplemented diet on systolic blood pressure (BP) and vasomotor functions in Sprague-Dawley (SD) and deoxycorticosterone acetate (DOCA)-salt hypertensive rats. SD and DOCA rats were fed a normal or a methionine (8 g/kg)-supplemented diet for 10 weeks. Systolic BP was monitored and plasma homocysteine, methionine and cysteine levels were determined at the end of the experiment. Vasoconstriction and vasodilatation of aortic rings were measured. The methionine-supplemented diet induced a greater increase in homocysteinaemia concentration in DOCA rats than in SD rats and an increase in plasma cysteine concentration in DOCA rats. This diet was associated with an increase in systolic BP in SD rats and with a lesser development of DOCA-salt hypertension. An enhanced aortic constriction and a decreased responsiveness to acetylcholine, bradykinin and sodium nitroprusside in the SD rats fed the methionine-rich diet were consistent with the elevated systolic BP. In DOCA rats the increased responsiveness to bradykinin was in accordance with the systolic BP-lowering effect. In conclusion, the methionine-enriched diet cannot simply be considered as model of hyperhomocysteinaemia, since other metabolites and mechanisms seemed to be implicated in these complex interactions. The differential vasopressive effect of the methionine supplementation in SD and DOCA rats, and in particular the lowering of systolic BP obtained with a greater degree of hyperhomocysteinaemia in DOCA rats, suggest that more complex interactions exist between hyperhomocysteinaemia and BP than the simple positive association described previously.

Authors+Show Affiliations

Laboratoire de Physiologie, Pharmacologie et Nutrition Préventive Expérimentale, Cedex, France. ROBINRobinson@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15182389

Citation

Robin, Sophie, et al. "Effect of a Methionine-supplemented Diet On the Blood Pressure of Sprague-Dawley and Deoxycorticosterone Acetate-salt Hypertensive Rats." The British Journal of Nutrition, vol. 91, no. 6, 2004, pp. 857-65.
Robin S, Maupoil V, Laurant P, et al. Effect of a methionine-supplemented diet on the blood pressure of Sprague-Dawley and deoxycorticosterone acetate-salt hypertensive rats. Br J Nutr. 2004;91(6):857-65.
Robin, S., Maupoil, V., Laurant, P., Jacqueson, A., & Berthelot, A. (2004). Effect of a methionine-supplemented diet on the blood pressure of Sprague-Dawley and deoxycorticosterone acetate-salt hypertensive rats. The British Journal of Nutrition, 91(6), 857-65.
Robin S, et al. Effect of a Methionine-supplemented Diet On the Blood Pressure of Sprague-Dawley and Deoxycorticosterone Acetate-salt Hypertensive Rats. Br J Nutr. 2004;91(6):857-65. PubMed PMID: 15182389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a methionine-supplemented diet on the blood pressure of Sprague-Dawley and deoxycorticosterone acetate-salt hypertensive rats. AU - Robin,Sophie, AU - Maupoil,Véronique, AU - Laurant,Pascal, AU - Jacqueson,Alain, AU - Berthelot,Alain, PY - 2004/6/9/pubmed PY - 2004/7/21/medline PY - 2004/6/9/entrez SP - 857 EP - 65 JF - The British journal of nutrition JO - Br J Nutr VL - 91 IS - 6 N2 - The objectives of the present study were to evaluate the effects of a methionine-supplemented diet on systolic blood pressure (BP) and vasomotor functions in Sprague-Dawley (SD) and deoxycorticosterone acetate (DOCA)-salt hypertensive rats. SD and DOCA rats were fed a normal or a methionine (8 g/kg)-supplemented diet for 10 weeks. Systolic BP was monitored and plasma homocysteine, methionine and cysteine levels were determined at the end of the experiment. Vasoconstriction and vasodilatation of aortic rings were measured. The methionine-supplemented diet induced a greater increase in homocysteinaemia concentration in DOCA rats than in SD rats and an increase in plasma cysteine concentration in DOCA rats. This diet was associated with an increase in systolic BP in SD rats and with a lesser development of DOCA-salt hypertension. An enhanced aortic constriction and a decreased responsiveness to acetylcholine, bradykinin and sodium nitroprusside in the SD rats fed the methionine-rich diet were consistent with the elevated systolic BP. In DOCA rats the increased responsiveness to bradykinin was in accordance with the systolic BP-lowering effect. In conclusion, the methionine-enriched diet cannot simply be considered as model of hyperhomocysteinaemia, since other metabolites and mechanisms seemed to be implicated in these complex interactions. The differential vasopressive effect of the methionine supplementation in SD and DOCA rats, and in particular the lowering of systolic BP obtained with a greater degree of hyperhomocysteinaemia in DOCA rats, suggest that more complex interactions exist between hyperhomocysteinaemia and BP than the simple positive association described previously. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/15182389/Effect_of_a_methionine_supplemented_diet_on_the_blood_pressure_of_Sprague_Dawley_and_deoxycorticosterone_acetate_salt_hypertensive_rats_ L2 - https://www.cambridge.org/core/product/identifier/S0007114504001060/type/journal_article DB - PRIME DP - Unbound Medicine ER -