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The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects.
Br J Nutr. 2004 Jun; 91(6):893-903.BJ

Abstract

To determine the effects of EPA, stearidonic acid (STA) or gamma-linolenic acid (GLA) on immune outcomes, healthy male subjects consumed one of seven oil blends for 12 weeks. EPA consumption increased the EPA content of peripheral blood mononuclear cells (PBMC). Consumption of GLA (2.0 g/d) in the absence of STA or EPA increased di-homo-GLA content in PBMC. Neither STA nor its derivative 20 : 4n-3 appeared in PBMC when STA (<1.0 g/d) was consumed. However, STA (1.0 g/d), in combination with GLA (0.9 g/d), increased the proportion of EPA in PBMC. None of the treatments altered neutrophil or monocyte phagocytosis or respiratory burst, production of inflammatory cytokines by monocytes, T lymphocyte proliferation or the delayed-type hypersensitivity response. Production of cytokines by T lymphocytes increased in all groups, with no differences among them. The proportion of lymphocytes that were natural killer cells decreased significantly in subjects receiving 2.0 g EPA or GLA/d. There were no other effects on lymphocyte sub-populations. Plasma IgE concentration decreased in most groups, but not in the control group. Plasma IgG2 concentration increased in the EPA group. Thus, EPA or GLA at a dose of 2.0 g/d have little effect on key functions of neutrophils, monocytes and T lymphocytes, although at this dose these fatty acids decrease the number of natural killer cells. At this dose EPA increases IgG2 concentrations. STA can increase immune cell EPA status, but at 1.0 g/d does not affect human immune function.

Authors+Show Affiliations

Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK. eam@soton.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15182393

Citation

Miles, Elizabeth A., et al. "The Influence of Different Combinations of Gamma-linolenic Acid, Stearidonic Acid and EPA On Immune Function in Healthy Young Male Subjects." The British Journal of Nutrition, vol. 91, no. 6, 2004, pp. 893-903.
Miles EA, Banerjee T, Dooper MM, et al. The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects. Br J Nutr. 2004;91(6):893-903.
Miles, E. A., Banerjee, T., Dooper, M. M., M'Rabet, L., Graus, Y. M., & Calder, P. C. (2004). The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects. The British Journal of Nutrition, 91(6), 893-903.
Miles EA, et al. The Influence of Different Combinations of Gamma-linolenic Acid, Stearidonic Acid and EPA On Immune Function in Healthy Young Male Subjects. Br J Nutr. 2004;91(6):893-903. PubMed PMID: 15182393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects. AU - Miles,Elizabeth A, AU - Banerjee,Tapati, AU - Dooper,Maaike M B W, AU - M'Rabet,Laura, AU - Graus,Yvo M F, AU - Calder,Philip C, PY - 2004/6/9/pubmed PY - 2004/7/21/medline PY - 2004/6/9/entrez SP - 893 EP - 903 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 91 IS - 6 N2 - To determine the effects of EPA, stearidonic acid (STA) or gamma-linolenic acid (GLA) on immune outcomes, healthy male subjects consumed one of seven oil blends for 12 weeks. EPA consumption increased the EPA content of peripheral blood mononuclear cells (PBMC). Consumption of GLA (2.0 g/d) in the absence of STA or EPA increased di-homo-GLA content in PBMC. Neither STA nor its derivative 20 : 4n-3 appeared in PBMC when STA (<1.0 g/d) was consumed. However, STA (1.0 g/d), in combination with GLA (0.9 g/d), increased the proportion of EPA in PBMC. None of the treatments altered neutrophil or monocyte phagocytosis or respiratory burst, production of inflammatory cytokines by monocytes, T lymphocyte proliferation or the delayed-type hypersensitivity response. Production of cytokines by T lymphocytes increased in all groups, with no differences among them. The proportion of lymphocytes that were natural killer cells decreased significantly in subjects receiving 2.0 g EPA or GLA/d. There were no other effects on lymphocyte sub-populations. Plasma IgE concentration decreased in most groups, but not in the control group. Plasma IgG2 concentration increased in the EPA group. Thus, EPA or GLA at a dose of 2.0 g/d have little effect on key functions of neutrophils, monocytes and T lymphocytes, although at this dose these fatty acids decrease the number of natural killer cells. At this dose EPA increases IgG2 concentrations. STA can increase immune cell EPA status, but at 1.0 g/d does not affect human immune function. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/15182393/The_influence_of_different_combinations_of_gamma_linolenic_acid_stearidonic_acid_and_EPA_on_immune_function_in_healthy_young_male_subjects_ L2 - https://www.cambridge.org/core/product/identifier/S0007114504001102/type/journal_article DB - PRIME DP - Unbound Medicine ER -