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Baroreflex control of renal sympathetic nerve activity and spontaneous rhythms at Mayer wave's frequency in rats.
Auton Neurosci. 2004 Apr 30; 111(2):80-8.AN

Abstract

The effects of sedation with pentobarbital sodium (15 mg/kg followed by 15.9+/-1.2 mg/kg/h, i.v.) on arterial pressure (AP) Mayer waves and accompanying oscillations of renal sympathetic nerve activity (RSNA) were examined in rats (n=8). As compared with values observed in the conscious state, pentobarbital significantly (P<0.05) decreased AP (from 119+/-2 to 93+/-3 mm Hg), heart rate (HR; from 427+/-11 to 355+/-11 beats/min) and RSNA (from 1.20+/-0.27 to 0.62+/-0.13 microV). The baroreflex control of RSNA was analyzed by fitting a sigmoid logistic function to changes in RSNA and AP observed during nitroprusside and phenylephrine administrations. During pentobarbital infusion, the RSNA-AP relationship was reset towards lower AP values, but neither its maximum gain nor its gain at resting AP were significantly altered (from 6.3+/-1.0 to 5.8+/-1.4 and from 3.2+/-0.5 to 3.8+/-1.3 normalized units (n.u.)/mm Hg, respectively). Spectral power in the frequency band containing Mayer waves (0.29-0.73 Hz) was significantly decreased by pentobarbital for both AP (from 4.65+/-0.90 to 0.95+/-0.25 mm Hg2) and RSNA (from 1437+/-245 to 488+/-79 n.u.2). This effect was mainly secondary to the attenuation of strongly coherent oscillations of both variables at approximately 0.4 Hz. Although previous experimental evidence points to a major involvement of the sympathetic limb of the arterial baroreceptor reflex in the genesis of Mayer waves, the present study indicates that the amplitude of these oscillations cannot be used as a quantitative index of sympathetic baroreflex sensitivity.

Authors+Show Affiliations

Département de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique Formation de Recherche en Evolution 2678, Faculté de Pharmacie, Université Claude Bernard Lyon 1, Lyon, Cedex 08, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15182737

Citation

Cheng, Yong, et al. "Baroreflex Control of Renal Sympathetic Nerve Activity and Spontaneous Rhythms at Mayer Wave's Frequency in Rats." Autonomic Neuroscience : Basic & Clinical, vol. 111, no. 2, 2004, pp. 80-8.
Cheng Y, Cohen B, Oréa V, et al. Baroreflex control of renal sympathetic nerve activity and spontaneous rhythms at Mayer wave's frequency in rats. Auton Neurosci. 2004;111(2):80-8.
Cheng, Y., Cohen, B., Oréa, V., Barrès, C., & Julien, C. (2004). Baroreflex control of renal sympathetic nerve activity and spontaneous rhythms at Mayer wave's frequency in rats. Autonomic Neuroscience : Basic & Clinical, 111(2), 80-8.
Cheng Y, et al. Baroreflex Control of Renal Sympathetic Nerve Activity and Spontaneous Rhythms at Mayer Wave's Frequency in Rats. Auton Neurosci. 2004 Apr 30;111(2):80-8. PubMed PMID: 15182737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Baroreflex control of renal sympathetic nerve activity and spontaneous rhythms at Mayer wave's frequency in rats. AU - Cheng,Yong, AU - Cohen,Benjamin, AU - Oréa,Valérie, AU - Barrès,Christian, AU - Julien,Claude, PY - 2003/12/08/received PY - 2004/02/10/revised PY - 2004/02/16/accepted PY - 2004/6/9/pubmed PY - 2004/8/25/medline PY - 2004/6/9/entrez SP - 80 EP - 8 JF - Autonomic neuroscience : basic & clinical JO - Auton Neurosci VL - 111 IS - 2 N2 - The effects of sedation with pentobarbital sodium (15 mg/kg followed by 15.9+/-1.2 mg/kg/h, i.v.) on arterial pressure (AP) Mayer waves and accompanying oscillations of renal sympathetic nerve activity (RSNA) were examined in rats (n=8). As compared with values observed in the conscious state, pentobarbital significantly (P<0.05) decreased AP (from 119+/-2 to 93+/-3 mm Hg), heart rate (HR; from 427+/-11 to 355+/-11 beats/min) and RSNA (from 1.20+/-0.27 to 0.62+/-0.13 microV). The baroreflex control of RSNA was analyzed by fitting a sigmoid logistic function to changes in RSNA and AP observed during nitroprusside and phenylephrine administrations. During pentobarbital infusion, the RSNA-AP relationship was reset towards lower AP values, but neither its maximum gain nor its gain at resting AP were significantly altered (from 6.3+/-1.0 to 5.8+/-1.4 and from 3.2+/-0.5 to 3.8+/-1.3 normalized units (n.u.)/mm Hg, respectively). Spectral power in the frequency band containing Mayer waves (0.29-0.73 Hz) was significantly decreased by pentobarbital for both AP (from 4.65+/-0.90 to 0.95+/-0.25 mm Hg2) and RSNA (from 1437+/-245 to 488+/-79 n.u.2). This effect was mainly secondary to the attenuation of strongly coherent oscillations of both variables at approximately 0.4 Hz. Although previous experimental evidence points to a major involvement of the sympathetic limb of the arterial baroreceptor reflex in the genesis of Mayer waves, the present study indicates that the amplitude of these oscillations cannot be used as a quantitative index of sympathetic baroreflex sensitivity. SN - 1566-0702 UR - https://www.unboundmedicine.com/medline/citation/15182737/Baroreflex_control_of_renal_sympathetic_nerve_activity_and_spontaneous_rhythms_at_Mayer_wave's_frequency_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1566-0702(04)00035-9 DB - PRIME DP - Unbound Medicine ER -