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The effect of Perasafe and sodium dichloroisocyanurate (NaDCC) against spores of Clostridium difficile and Bacillus atrophaeus on stainless steel and polyvinyl chloride surfaces.
J Hosp Infect. 2004 Jun; 57(2):144-8.JH

Abstract

Clostridium difficile is an important cause of nosocomial diarrhoea. The aim of this study was to evaluate the potential for Perasafe, a recently introduced biocide, to contribute to control of C. difficile spores in the patient environment, in comparison with the chlorine-releasing agent sodium dichloroisocyanurate (NaDCC). These agents were evaluated against a water control, in a surface test on stainless steel and polyvinyl chloride (PVC) floor covering, materials commonly found in the hospital environment. The organisms studied were a toxigenic clinical isolate of C. difficile, and Bacillus atrophaeus (formerly B. subtilis var niger). The data indicate that in our in vitro system, Perasafe was significantly more active than NaDCC (1000 ppm available chlorine) against C. difficile spores dried on stainless steel surfaces, and against B. atrophaeus on PVC floor covering material, achieving mean log10 reduction factors in viable counts of 6 and 5.5, respectively, at 10 min exposures. Perasafe appeared to be less lethal in 10 min exposures to C. difficile spores fixed on PVC floor covering material. In general, 1000 ppm chlorine generated from NaDCC showed lower log10 reduction factors in viable counts at 10 min, ranging from 0.7 to 1.5, than Perasafe which ranged from 2.7 to 6.0. The potential efficacy of Perasafe in reducing the density of C. difficile spores in the patient environment in hospitals, nursing homes or other long-stay facilities should be evaluated in field studies.

Authors+Show Affiliations

Department of Clinical Microbiology and Infectious Diseases, Hadassah-University Hospital, PO Box 12000, Jerusalem, Israel. block@md.huji.ac.il

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15183245

Citation

Block, C. "The Effect of Perasafe and Sodium Dichloroisocyanurate (NaDCC) Against Spores of Clostridium Difficile and Bacillus Atrophaeus On Stainless Steel and Polyvinyl Chloride Surfaces." The Journal of Hospital Infection, vol. 57, no. 2, 2004, pp. 144-8.
Block C. The effect of Perasafe and sodium dichloroisocyanurate (NaDCC) against spores of Clostridium difficile and Bacillus atrophaeus on stainless steel and polyvinyl chloride surfaces. J Hosp Infect. 2004;57(2):144-8.
Block, C. (2004). The effect of Perasafe and sodium dichloroisocyanurate (NaDCC) against spores of Clostridium difficile and Bacillus atrophaeus on stainless steel and polyvinyl chloride surfaces. The Journal of Hospital Infection, 57(2), 144-8.
Block C. The Effect of Perasafe and Sodium Dichloroisocyanurate (NaDCC) Against Spores of Clostridium Difficile and Bacillus Atrophaeus On Stainless Steel and Polyvinyl Chloride Surfaces. J Hosp Infect. 2004;57(2):144-8. PubMed PMID: 15183245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of Perasafe and sodium dichloroisocyanurate (NaDCC) against spores of Clostridium difficile and Bacillus atrophaeus on stainless steel and polyvinyl chloride surfaces. A1 - Block,C, PY - 2003/10/07/received PY - 2004/01/19/accepted PY - 2004/6/9/pubmed PY - 2004/11/9/medline PY - 2004/6/9/entrez SP - 144 EP - 8 JF - The Journal of hospital infection JO - J Hosp Infect VL - 57 IS - 2 N2 - Clostridium difficile is an important cause of nosocomial diarrhoea. The aim of this study was to evaluate the potential for Perasafe, a recently introduced biocide, to contribute to control of C. difficile spores in the patient environment, in comparison with the chlorine-releasing agent sodium dichloroisocyanurate (NaDCC). These agents were evaluated against a water control, in a surface test on stainless steel and polyvinyl chloride (PVC) floor covering, materials commonly found in the hospital environment. The organisms studied were a toxigenic clinical isolate of C. difficile, and Bacillus atrophaeus (formerly B. subtilis var niger). The data indicate that in our in vitro system, Perasafe was significantly more active than NaDCC (1000 ppm available chlorine) against C. difficile spores dried on stainless steel surfaces, and against B. atrophaeus on PVC floor covering material, achieving mean log10 reduction factors in viable counts of 6 and 5.5, respectively, at 10 min exposures. Perasafe appeared to be less lethal in 10 min exposures to C. difficile spores fixed on PVC floor covering material. In general, 1000 ppm chlorine generated from NaDCC showed lower log10 reduction factors in viable counts at 10 min, ranging from 0.7 to 1.5, than Perasafe which ranged from 2.7 to 6.0. The potential efficacy of Perasafe in reducing the density of C. difficile spores in the patient environment in hospitals, nursing homes or other long-stay facilities should be evaluated in field studies. SN - 0195-6701 UR - https://www.unboundmedicine.com/medline/citation/15183245/The_effect_of_Perasafe_and_sodium_dichloroisocyanurate__NaDCC__against_spores_of_Clostridium_difficile_and_Bacillus_atrophaeus_on_stainless_steel_and_polyvinyl_chloride_surfaces_ DB - PRIME DP - Unbound Medicine ER -