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Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish.
Gene Expr Patterns. 2004 Jul; 4(4):481-6.GE

Abstract

sax1/nkx1.2 and sax2/nkx1.1 are members of the evolutionally conserved NK-1 homeobox gene family. sax1/nkx1.2 is reported to be expressed in the central nervous system during early and late neurogenesis in the chick and mouse, but the expression of sax2/nkx1.1 has not been reported. We isolated zebrafish cDNAs for sax1/nkx1.2 and sax2/nkx1.1 and examined their expression. In zebrafish, unlike chick and mouse, sax1/nkx1.2 was expressed in the prospective medial floor plate from the mid-gastrula period and was dependent on Nodal signaling. From the early segmentation period, sax1/nkx1.2 was also expressed in the posterior neuroectoderm. sax2/nkx1.1 was expressed in the prospective extraocular muscles, mesencephalic neurons residing along the tract of the posterior commissure, ventral neurons in the hindbrain, and interneurons in the spinal cord.

Authors+Show Affiliations

Laboratory for Vertebrate Axis Formation, Center for Developmental Biology, RIKEN, 2-2-3 Minatojima-minami, Chuo-ku, Kobe, Hyogo 650-0047, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15183316

Citation

Bae, Young-Ki, et al. "Expression of Sax1/nkx1.2 and Sax2/nkx1.1 in Zebrafish." Gene Expression Patterns : GEP, vol. 4, no. 4, 2004, pp. 481-6.
Bae YK, Shimizu T, Muraoka O, et al. Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. Gene Expr Patterns. 2004;4(4):481-6.
Bae, Y. K., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., & Hibi, M. (2004). Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. Gene Expression Patterns : GEP, 4(4), 481-6.
Bae YK, et al. Expression of Sax1/nkx1.2 and Sax2/nkx1.1 in Zebrafish. Gene Expr Patterns. 2004;4(4):481-6. PubMed PMID: 15183316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. AU - Bae,Young-Ki, AU - Shimizu,Takashi, AU - Muraoka,Osamu, AU - Yabe,Taijiro, AU - Hirata,Tsutomu, AU - Nojima,Hideaki, AU - Hirano,Toshio, AU - Hibi,Masahiko, PY - 2003/10/24/received PY - 2003/12/08/revised PY - 2003/12/08/accepted PY - 2004/6/9/pubmed PY - 2005/2/3/medline PY - 2004/6/9/entrez SP - 481 EP - 6 JF - Gene expression patterns : GEP JO - Gene Expr. Patterns VL - 4 IS - 4 N2 - sax1/nkx1.2 and sax2/nkx1.1 are members of the evolutionally conserved NK-1 homeobox gene family. sax1/nkx1.2 is reported to be expressed in the central nervous system during early and late neurogenesis in the chick and mouse, but the expression of sax2/nkx1.1 has not been reported. We isolated zebrafish cDNAs for sax1/nkx1.2 and sax2/nkx1.1 and examined their expression. In zebrafish, unlike chick and mouse, sax1/nkx1.2 was expressed in the prospective medial floor plate from the mid-gastrula period and was dependent on Nodal signaling. From the early segmentation period, sax1/nkx1.2 was also expressed in the posterior neuroectoderm. sax2/nkx1.1 was expressed in the prospective extraocular muscles, mesencephalic neurons residing along the tract of the posterior commissure, ventral neurons in the hindbrain, and interneurons in the spinal cord. SN - 1567-133X UR - https://www.unboundmedicine.com/medline/citation/15183316/Expression_of_sax1/nkx1_2_and_sax2/nkx1_1_in_zebrafish_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567133X03002254 DB - PRIME DP - Unbound Medicine ER -