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The protective effect of taurine against cyclosporine A-induced oxidative stress and hepatotoxicity in rats.

Abstract

Cyclosporine A (CsA) is the immunosuppressor which is most frequently used in transplant surgery and in the treatment of autoimmune diseases. Oxidative stress has been implicated as one of the possible mechanisms of CsA-induced hepatotoxicity. The present investigation examined the ability of taurine as an antioxidant to protect against CsA-induced oxidative stress and hepatotoxicity. CsA hepatotoxicity was induced by subcutaneous injection of CsA at a dose of 20mg/kg body weight daily for 21 days. Hepatotoxicity was assessed by reduced serum total protein level and increased serum levels of gamma glutamyl transferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransaminase (AST). CsA treatment increased lipid peroxidation measured as thiobarbituric acid reactive substances (TBARS) concentration and decreased reduced glutathione (GSH) content and activities of catalase and glutathione peroxidase (GSH-Px) in the rat liver. Taurine administration (1% in the drinking water) for 3 days before and concurrently during CsA injections improved liver functions, as indicated by decline of serum transaminases and GGT levels and elevation of serum total protein. Moreover, taurine significantly reduced hepatic TBARS and increased GSH content and catalase and GSH-Px activities in the hepatic tissue. These results indicate that taurine has a protective action against CsA hepatotoxicity and suggest that taurine may find clinical application against a variety of toxins where cellular damage is a consequence of reactive oxygen species.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Department of Pharmacology, College of Medicine and KHUH, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi Arabia. hananhhagar@yahoo.com

    Source

    Toxicology letters 151:2 2004 Jul 15 pg 335-43

    MeSH

    Administration, Oral
    Animals
    Antioxidants
    Chemical and Drug Induced Liver Injury
    Cyclosporine
    Drug Antagonism
    Immunosuppressive Agents
    Injections, Subcutaneous
    Liver
    Male
    Oxidative Stress
    Rats
    Rats, Wistar
    Taurine
    Thiobarbituric Acid Reactive Substances
    Water Supply

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    15183458

    Citation

    Hagar, Hanan H.. "The Protective Effect of Taurine Against Cyclosporine A-induced Oxidative Stress and Hepatotoxicity in Rats." Toxicology Letters, vol. 151, no. 2, 2004, pp. 335-43.
    Hagar HH. The protective effect of taurine against cyclosporine A-induced oxidative stress and hepatotoxicity in rats. Toxicol Lett. 2004;151(2):335-43.
    Hagar, H. H. (2004). The protective effect of taurine against cyclosporine A-induced oxidative stress and hepatotoxicity in rats. Toxicology Letters, 151(2), pp. 335-43.
    Hagar HH. The Protective Effect of Taurine Against Cyclosporine A-induced Oxidative Stress and Hepatotoxicity in Rats. Toxicol Lett. 2004 Jul 15;151(2):335-43. PubMed PMID: 15183458.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The protective effect of taurine against cyclosporine A-induced oxidative stress and hepatotoxicity in rats. A1 - Hagar,Hanan H, PY - 2003/12/11/received PY - 2004/02/24/revised PY - 2004/03/04/accepted PY - 2004/6/9/pubmed PY - 2004/7/21/medline PY - 2004/6/9/entrez SP - 335 EP - 43 JF - Toxicology letters JO - Toxicol. Lett. VL - 151 IS - 2 N2 - Cyclosporine A (CsA) is the immunosuppressor which is most frequently used in transplant surgery and in the treatment of autoimmune diseases. Oxidative stress has been implicated as one of the possible mechanisms of CsA-induced hepatotoxicity. The present investigation examined the ability of taurine as an antioxidant to protect against CsA-induced oxidative stress and hepatotoxicity. CsA hepatotoxicity was induced by subcutaneous injection of CsA at a dose of 20mg/kg body weight daily for 21 days. Hepatotoxicity was assessed by reduced serum total protein level and increased serum levels of gamma glutamyl transferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransaminase (AST). CsA treatment increased lipid peroxidation measured as thiobarbituric acid reactive substances (TBARS) concentration and decreased reduced glutathione (GSH) content and activities of catalase and glutathione peroxidase (GSH-Px) in the rat liver. Taurine administration (1% in the drinking water) for 3 days before and concurrently during CsA injections improved liver functions, as indicated by decline of serum transaminases and GGT levels and elevation of serum total protein. Moreover, taurine significantly reduced hepatic TBARS and increased GSH content and catalase and GSH-Px activities in the hepatic tissue. These results indicate that taurine has a protective action against CsA hepatotoxicity and suggest that taurine may find clinical application against a variety of toxins where cellular damage is a consequence of reactive oxygen species. SN - 0378-4274 UR - https://www.unboundmedicine.com/medline/citation/15183458/The_protective_effect_of_taurine_against_cyclosporine_A_induced_oxidative_stress_and_hepatotoxicity_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378427404001444 DB - PRIME DP - Unbound Medicine ER -