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The role of free oxygen radicals on the development of otitis media with effusion.

Abstract

OBJECTIVE

The purpose of this study was to determine if free oxygen radicals (FORs) and antioxidant enzyme activities have some role in pathogenesis of otitis media with effusion (OME) in children with adenoid hyperplasia.

METHODS

Seventy-four patients were enrolled in three groups of this study. The study group (Group I) included 26 patients who had adenoidectomy with ventilation tube placement due to chronic OME. The control adenoid group (Group II) consisted of 28 age-matched patients who had adenoidectomy without ventilation tube insertion. Twenty children were included in the healthy control group (Group III). Erythrocyte malondialdehyde (MDA) levels, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) enzyme activities were investigated in the venous blood sample.

RESULTS

Erythrocyte MDA level and GSH-Px enzyme activity in the blood samples of study group (Group I) were significantly higher than those of Group II and Group III (P < 0.05). SOD enzyme activity in the blood samples of Group I was significantly lower than Group II (P < 0.05), and were significantly higher than Group III (P < 0.05). CAT enzyme activity of Group I was significantly lower than that of Group III (P < 0.05). However, there was no statistically significant difference between Group I and Group II regarding CAT antioxidant enzyme activity (P < 0.05).

CONCLUSIONS

The inflammation of the middle ear increases the level of FORs in erythrocyte. FOR level is normally maintained at a steady state by antioxidant enzymes. When the antioxidant defense system is weakened, the increased FORs may contribute to OME formation. We supposed that, antioxidant vitamins C and E, and scavenger enzymes such as CAT, SOD and GSH-Px may be added in the management of OME.

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  • Authors+Show Affiliations

    ,

    Head and Neck Surgery Department, School of Medicine, Suleyman Demirel University, Yayla M. 1604 S 5/3, Isparta 32100, Turkey. myariktas@hotmail.com

    , , ,

    Source

    MeSH

    Adenoidectomy
    Adolescent
    Ascorbic Acid
    Catalase
    Child
    Child, Preschool
    Erythrocytes
    Female
    Free Radicals
    Glutathione Peroxidase
    Humans
    Male
    Malondialdehyde
    Otitis Media with Effusion
    Reactive Oxygen Species
    Superoxide Dismutase
    Tonsillectomy
    Vitamin E

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    15183579

    Citation

    Yariktas, Murat, et al. "The Role of Free Oxygen Radicals On the Development of Otitis Media With Effusion." International Journal of Pediatric Otorhinolaryngology, vol. 68, no. 7, 2004, pp. 889-94.
    Yariktas M, Doner F, Dogru H, et al. The role of free oxygen radicals on the development of otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2004;68(7):889-94.
    Yariktas, M., Doner, F., Dogru, H., Yasan, H., & Delibas, N. (2004). The role of free oxygen radicals on the development of otitis media with effusion. International Journal of Pediatric Otorhinolaryngology, 68(7), pp. 889-94.
    Yariktas M, et al. The Role of Free Oxygen Radicals On the Development of Otitis Media With Effusion. Int J Pediatr Otorhinolaryngol. 2004;68(7):889-94. PubMed PMID: 15183579.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The role of free oxygen radicals on the development of otitis media with effusion. AU - Yariktas,Murat, AU - Doner,Fehmi, AU - Dogru,Harun, AU - Yasan,Hasan, AU - Delibas,Namik, PY - 2003/09/03/received PY - 2004/01/27/revised PY - 2004/02/02/accepted PY - 2004/6/9/pubmed PY - 2004/10/8/medline PY - 2004/6/9/entrez SP - 889 EP - 94 JF - International journal of pediatric otorhinolaryngology JO - Int. J. Pediatr. Otorhinolaryngol. VL - 68 IS - 7 N2 - OBJECTIVE: The purpose of this study was to determine if free oxygen radicals (FORs) and antioxidant enzyme activities have some role in pathogenesis of otitis media with effusion (OME) in children with adenoid hyperplasia. METHODS: Seventy-four patients were enrolled in three groups of this study. The study group (Group I) included 26 patients who had adenoidectomy with ventilation tube placement due to chronic OME. The control adenoid group (Group II) consisted of 28 age-matched patients who had adenoidectomy without ventilation tube insertion. Twenty children were included in the healthy control group (Group III). Erythrocyte malondialdehyde (MDA) levels, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) enzyme activities were investigated in the venous blood sample. RESULTS: Erythrocyte MDA level and GSH-Px enzyme activity in the blood samples of study group (Group I) were significantly higher than those of Group II and Group III (P < 0.05). SOD enzyme activity in the blood samples of Group I was significantly lower than Group II (P < 0.05), and were significantly higher than Group III (P < 0.05). CAT enzyme activity of Group I was significantly lower than that of Group III (P < 0.05). However, there was no statistically significant difference between Group I and Group II regarding CAT antioxidant enzyme activity (P < 0.05). CONCLUSIONS: The inflammation of the middle ear increases the level of FORs in erythrocyte. FOR level is normally maintained at a steady state by antioxidant enzymes. When the antioxidant defense system is weakened, the increased FORs may contribute to OME formation. We supposed that, antioxidant vitamins C and E, and scavenger enzymes such as CAT, SOD and GSH-Px may be added in the management of OME. SN - 0165-5876 UR - https://www.unboundmedicine.com/medline/citation/15183579/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165587604000497 DB - PRIME DP - Unbound Medicine ER -