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Apolipoprotein E gene polymorphism effects triglycerides but not CAD risk in Caucasian women younger than 65 years.
Ann Genet. 2004 Apr-Jun; 47(2):147-53.AG

Abstract

The pathogenesis of CAD is similar in man and woman, yet some risk factors have a greater impact on the CAD risk in woman than in man. In this study we assessed the effect of the apoE gene polymorphism on lipid metabolism and risk for CAD in women younger than 65 years (premature CAD). In a cross-sectional case-control study, 147 female Caucasian patients with premature CAD (confirmed by coronarography) were compared with a control group of 114 healthy Caucasian women. The apoE allele frequencies of patients vs. controls were 5.1% vs. 5.7% for 2, 85.4% vs. 83.3% for 3, and 9.5% vs. 11% for epsilon4. The subjects with epsilon2/3 genotype had statistically significantly higher triglycerides levels than the subjects with epsilon3/3 genotype (2.23 +/- 2.13 mmol.L(-1) vs. 1.73 +/- 0.84 mmol.L(-1); p<0.05). Logistic regression analysis revealed no association between risk genotypes (3/4 and 4/4) of the apoE gene polymorphism and CAD risk (OR 0.9; 95% CI 0. 5-1.7, P=0.7). We observed metabolic clustering of diabetes mellitus, arterial hypertension, higher BMI and triglycerides, and lower HDL cholesterol in the CAD group compared to the control group. Arterial hypertension, diabetes, HDL cholesterol level, and BMI were independent risk factors for premature CAD in female population, whereas, the risk genotype of the apoE gene polymorphism was not. In conclusion, in Slovene women risk genotypes of the apoE gene polymorphism are not associated with premature CAD; a metabolic clustering of diabetes, HDL, triglycerides and arterial hypertension is frequently present in Caucasian women with premature CAD.

Authors+Show Affiliations

Department of Internal Medicine, General Hospital Ptuj, Slovenia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15183747

Citation

Letonja, Mitja, et al. "Apolipoprotein E Gene Polymorphism Effects Triglycerides but Not CAD Risk in Caucasian Women Younger Than 65 Years." Annales De Genetique, vol. 47, no. 2, 2004, pp. 147-53.
Letonja M, Guzic-Salobir B, Peterlin B, et al. Apolipoprotein E gene polymorphism effects triglycerides but not CAD risk in Caucasian women younger than 65 years. Ann Genet. 2004;47(2):147-53.
Letonja, M., Guzic-Salobir, B., Peterlin, B., & Petrovic, D. (2004). Apolipoprotein E gene polymorphism effects triglycerides but not CAD risk in Caucasian women younger than 65 years. Annales De Genetique, 47(2), 147-53.
Letonja M, et al. Apolipoprotein E Gene Polymorphism Effects Triglycerides but Not CAD Risk in Caucasian Women Younger Than 65 Years. Ann Genet. 2004 Apr-Jun;47(2):147-53. PubMed PMID: 15183747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E gene polymorphism effects triglycerides but not CAD risk in Caucasian women younger than 65 years. AU - Letonja,Mitja, AU - Guzic-Salobir,Barbara, AU - Peterlin,Borut, AU - Petrovic,Daniel, PY - 2003/09/26/received PY - 2004/01/22/accepted PY - 2004/6/9/pubmed PY - 2005/10/7/medline PY - 2004/6/9/entrez SP - 147 EP - 53 JF - Annales de genetique JO - Ann Genet VL - 47 IS - 2 N2 - The pathogenesis of CAD is similar in man and woman, yet some risk factors have a greater impact on the CAD risk in woman than in man. In this study we assessed the effect of the apoE gene polymorphism on lipid metabolism and risk for CAD in women younger than 65 years (premature CAD). In a cross-sectional case-control study, 147 female Caucasian patients with premature CAD (confirmed by coronarography) were compared with a control group of 114 healthy Caucasian women. The apoE allele frequencies of patients vs. controls were 5.1% vs. 5.7% for 2, 85.4% vs. 83.3% for 3, and 9.5% vs. 11% for epsilon4. The subjects with epsilon2/3 genotype had statistically significantly higher triglycerides levels than the subjects with epsilon3/3 genotype (2.23 +/- 2.13 mmol.L(-1) vs. 1.73 +/- 0.84 mmol.L(-1); p<0.05). Logistic regression analysis revealed no association between risk genotypes (3/4 and 4/4) of the apoE gene polymorphism and CAD risk (OR 0.9; 95% CI 0. 5-1.7, P=0.7). We observed metabolic clustering of diabetes mellitus, arterial hypertension, higher BMI and triglycerides, and lower HDL cholesterol in the CAD group compared to the control group. Arterial hypertension, diabetes, HDL cholesterol level, and BMI were independent risk factors for premature CAD in female population, whereas, the risk genotype of the apoE gene polymorphism was not. In conclusion, in Slovene women risk genotypes of the apoE gene polymorphism are not associated with premature CAD; a metabolic clustering of diabetes, HDL, triglycerides and arterial hypertension is frequently present in Caucasian women with premature CAD. SN - 0003-3995 UR - https://www.unboundmedicine.com/medline/citation/15183747/Apolipoprotein_E_gene_polymorphism_effects_triglycerides_but_not_CAD_risk_in_Caucasian_women_younger_than_65_years_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003399504000097 DB - PRIME DP - Unbound Medicine ER -