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Does refractive error influence the association of blood pressure and retinal vessel diameters? The Blue Mountains Eye Study.
Am J Ophthalmol. 2004 Jun; 137(6):1050-5.AJ

Abstract

PURPOSE

To determine if refractive errors influence the association of blood pressure and retinal vessel diameters.

DESIGN

Population-based, cross-sectional study.

METHODS

Retinal photographs from the right eyes of participants (n = 3,654, aged 49+ years) in the Blue Mountains Eye Study taken during baseline examinations (1992 to 1994) were digitized. The diameter of all retinal vessels located half to one disk diameter from the disk margin was measured using a computer-assisted imaging program. These measurements were combined to provide the average diameters of retinal arterioles and venules of that eye, and the ratio of their diameters, the arteriole-to-venule ratio (AVR). The association of blood pressure and retinal vessel diameters was analyzed before and after correction for refraction using the Bengtsson formula.

RESULTS

Before correction, each 10-mm Hg increase in mean arterial blood pressure was associated with a 3.7-microm (95% confidence interval [CI], 3.2-4.3) decrease in arteriolar diameter and a 0.9-microm (95% CI, 0.3-0.9) decrease in venular diameter. After correction for refraction, each 1-mm Hg increase in mean arterial blood pressure was associated with a 3.7-microm (95% CI, 3.2-4.2) decrease in arteriolar diameter and a 0.8-microm (95% CI, 0.3-0.9) decrease in venular diameter. Refraction was not associated with the AVR and had no effect on the association of blood pressure and AVR.

CONCLUSION

Refraction had no appreciable effect on the association of blood pressure and retinal vessel diameters or on the AVR. Correction for refraction is important for quantifying absolute retinal vessel caliber, but may not be particularly important in epidemiologic studies investigating the association of generalized retinal arteriolar narrowing and hypertension.

Authors+Show Affiliations

Centre for Eye Research Australia, University of Melbourne, East Melbourne.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15183789

Citation

Wong, Tien Yin, et al. "Does Refractive Error Influence the Association of Blood Pressure and Retinal Vessel Diameters? the Blue Mountains Eye Study." American Journal of Ophthalmology, vol. 137, no. 6, 2004, pp. 1050-5.
Wong TY, Wang JJ, Rochtchina E, et al. Does refractive error influence the association of blood pressure and retinal vessel diameters? The Blue Mountains Eye Study. Am J Ophthalmol. 2004;137(6):1050-5.
Wong, T. Y., Wang, J. J., Rochtchina, E., Klein, R., & Mitchell, P. (2004). Does refractive error influence the association of blood pressure and retinal vessel diameters? The Blue Mountains Eye Study. American Journal of Ophthalmology, 137(6), 1050-5.
Wong TY, et al. Does Refractive Error Influence the Association of Blood Pressure and Retinal Vessel Diameters? the Blue Mountains Eye Study. Am J Ophthalmol. 2004;137(6):1050-5. PubMed PMID: 15183789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does refractive error influence the association of blood pressure and retinal vessel diameters? The Blue Mountains Eye Study. AU - Wong,Tien Yin, AU - Wang,Jie Jin, AU - Rochtchina,Elena, AU - Klein,Ronald, AU - Mitchell,Paul, PY - 2004/01/06/accepted PY - 2004/6/9/pubmed PY - 2004/6/29/medline PY - 2004/6/9/entrez SP - 1050 EP - 5 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 137 IS - 6 N2 - PURPOSE: To determine if refractive errors influence the association of blood pressure and retinal vessel diameters. DESIGN: Population-based, cross-sectional study. METHODS: Retinal photographs from the right eyes of participants (n = 3,654, aged 49+ years) in the Blue Mountains Eye Study taken during baseline examinations (1992 to 1994) were digitized. The diameter of all retinal vessels located half to one disk diameter from the disk margin was measured using a computer-assisted imaging program. These measurements were combined to provide the average diameters of retinal arterioles and venules of that eye, and the ratio of their diameters, the arteriole-to-venule ratio (AVR). The association of blood pressure and retinal vessel diameters was analyzed before and after correction for refraction using the Bengtsson formula. RESULTS: Before correction, each 10-mm Hg increase in mean arterial blood pressure was associated with a 3.7-microm (95% confidence interval [CI], 3.2-4.3) decrease in arteriolar diameter and a 0.9-microm (95% CI, 0.3-0.9) decrease in venular diameter. After correction for refraction, each 1-mm Hg increase in mean arterial blood pressure was associated with a 3.7-microm (95% CI, 3.2-4.2) decrease in arteriolar diameter and a 0.8-microm (95% CI, 0.3-0.9) decrease in venular diameter. Refraction was not associated with the AVR and had no effect on the association of blood pressure and AVR. CONCLUSION: Refraction had no appreciable effect on the association of blood pressure and retinal vessel diameters or on the AVR. Correction for refraction is important for quantifying absolute retinal vessel caliber, but may not be particularly important in epidemiologic studies investigating the association of generalized retinal arteriolar narrowing and hypertension. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/15183789/Does_refractive_error_influence_the_association_of_blood_pressure_and_retinal_vessel_diameters_The_Blue_Mountains_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002939404000364 DB - PRIME DP - Unbound Medicine ER -