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Geranyl chalcone derivatives with antifungal and radical scavenging properties from the leaves of Artocarpus nobilis.
Phytochemistry. 2004 May; 65(9):1287-90.P

Abstract

Antifungal activity guided fractionation of the n-butanol extract from the methanol extract of the leaves of Artocarpus nobilis furnished 2',4',4-trihydroxy-3'-geranylchalcone (1), 2 ',4',4-trihydroxy-3'-[6-hydroxy-3,7-dimethyl-2(E),7-octadienyl]chalcone (2), 2',4',4-trihydroxy-3'-[2-hydroxy-7-methyl-3-methylene-6-octaenyl]chalcone (3), 2',3,4,4'-tetrahydroxy-3'-geranylchalcone (4), 2',3,4,4'-tetrahydroxy-3'-[6-hydroxy-3,7-dimethyl-2(E),7-octadienyl]chalcone (5). The chalcones 3 and 5 are new natural products whereas 1 and 2 are reported first time from the family Moraceae. All these compounds showed good fungicidal activity against Cladosporium cladosporioides and high radical scavenging activity towards the 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical in TLC bio-autography method.

Authors+Show Affiliations

Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka. lalith@ifs.ac.lkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15184014

Citation

Jayasinghe, Lalith, et al. "Geranyl Chalcone Derivatives With Antifungal and Radical Scavenging Properties From the Leaves of Artocarpus Nobilis." Phytochemistry, vol. 65, no. 9, 2004, pp. 1287-90.
Jayasinghe L, Balasooriya BA, Padmini WC, et al. Geranyl chalcone derivatives with antifungal and radical scavenging properties from the leaves of Artocarpus nobilis. Phytochemistry. 2004;65(9):1287-90.
Jayasinghe, L., Balasooriya, B. A., Padmini, W. C., Hara, N., & Fujimoto, Y. (2004). Geranyl chalcone derivatives with antifungal and radical scavenging properties from the leaves of Artocarpus nobilis. Phytochemistry, 65(9), 1287-90.
Jayasinghe L, et al. Geranyl Chalcone Derivatives With Antifungal and Radical Scavenging Properties From the Leaves of Artocarpus Nobilis. Phytochemistry. 2004;65(9):1287-90. PubMed PMID: 15184014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Geranyl chalcone derivatives with antifungal and radical scavenging properties from the leaves of Artocarpus nobilis. AU - Jayasinghe,Lalith, AU - Balasooriya,B A I S, AU - Padmini,W Chintha, AU - Hara,Noriyuki, AU - Fujimoto,Yoshinori, PY - 2003/11/14/received PY - 2004/03/26/accepted PY - 2004/6/9/pubmed PY - 2004/8/20/medline PY - 2004/6/9/entrez SP - 1287 EP - 90 JF - Phytochemistry JO - Phytochemistry VL - 65 IS - 9 N2 - Antifungal activity guided fractionation of the n-butanol extract from the methanol extract of the leaves of Artocarpus nobilis furnished 2',4',4-trihydroxy-3'-geranylchalcone (1), 2 ',4',4-trihydroxy-3'-[6-hydroxy-3,7-dimethyl-2(E),7-octadienyl]chalcone (2), 2',4',4-trihydroxy-3'-[2-hydroxy-7-methyl-3-methylene-6-octaenyl]chalcone (3), 2',3,4,4'-tetrahydroxy-3'-geranylchalcone (4), 2',3,4,4'-tetrahydroxy-3'-[6-hydroxy-3,7-dimethyl-2(E),7-octadienyl]chalcone (5). The chalcones 3 and 5 are new natural products whereas 1 and 2 are reported first time from the family Moraceae. All these compounds showed good fungicidal activity against Cladosporium cladosporioides and high radical scavenging activity towards the 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical in TLC bio-autography method. SN - 0031-9422 UR - https://www.unboundmedicine.com/medline/citation/15184014/Geranyl_chalcone_derivatives_with_antifungal_and_radical_scavenging_properties_from_the_leaves_of_Artocarpus_nobilis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031942204001487 DB - PRIME DP - Unbound Medicine ER -