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Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa.
Biol Pharm Bull. 2004 Jun; 27(6):926-8.BP

Abstract

Nine quinolone alkaloids (1-9) from the fruits of Evodia rutaecarpa were investigated for their inhibitory activity on nuclear factor of activated T cells (NFAT)-dependent transcription in comparison with nuclear factor (NF)-kappa B-dependent transcription using a reporter gene assay. These alkaloids showed inhibitory effects against NFAT activity, with IC(50) values between 0.91 microM and 15.91 microM. Of the N-methylated quinolones, the longer aliphatic side chain at the quinolone ring showed stronger inhibition of NFAT activity. These N-methylated compounds showed comparable inhibitory effects against NF-kappa B activity. However, quinolone alkaloids without the N-methyl group showed a more selective inhibition of NFAT activity.

Authors+Show Affiliations

Jin HZ
Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon, Korea.
Lee JH
No affiliation info available
Lee D
No affiliation info available
Lee HS
No affiliation info available
Hong YS
No affiliation info available
Kim YH
No affiliation info available
Lee JJ
No affiliation info available

MeSH

AlkaloidsAnimalsDNA-Binding ProteinsEvodiaFruitHumansImmunosuppressive AgentsJurkat CellsLymphocyte ActivationMiceNFATC Transcription FactorsNuclear ProteinsPlant ExtractsQuinolonesT-Lymphocyte SubsetsTranscription Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15187449

Citation

Jin, Hui Zi, et al. "Quinolone Alkaloids With Inhibitory Activity Against Nuclear Factor of Activated T Cells From the Fruits of Evodia Rutaecarpa." Biological & Pharmaceutical Bulletin, vol. 27, no. 6, 2004, pp. 926-8.
Jin HZ, Lee JH, Lee D, et al. Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa. Biol Pharm Bull. 2004;27(6):926-8.
Jin, H. Z., Lee, J. H., Lee, D., Lee, H. S., Hong, Y. S., Kim, Y. H., & Lee, J. J. (2004). Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa. Biological & Pharmaceutical Bulletin, 27(6), 926-8.
Jin HZ, et al. Quinolone Alkaloids With Inhibitory Activity Against Nuclear Factor of Activated T Cells From the Fruits of Evodia Rutaecarpa. Biol Pharm Bull. 2004;27(6):926-8. PubMed PMID: 15187449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa. AU - Jin,Hui Zi, AU - Lee,Jeong Hyung, AU - Lee,Dongho, AU - Lee,Hyun Sun, AU - Hong,Young Soo, AU - Kim,Young Ho, AU - Lee,Jung Joon, PY - 2004/6/10/pubmed PY - 2005/1/26/medline PY - 2004/6/10/entrez SP - 926 EP - 8 JF - Biological & pharmaceutical bulletin JO - Biol Pharm Bull VL - 27 IS - 6 N2 - Nine quinolone alkaloids (1-9) from the fruits of Evodia rutaecarpa were investigated for their inhibitory activity on nuclear factor of activated T cells (NFAT)-dependent transcription in comparison with nuclear factor (NF)-kappa B-dependent transcription using a reporter gene assay. These alkaloids showed inhibitory effects against NFAT activity, with IC(50) values between 0.91 microM and 15.91 microM. Of the N-methylated quinolones, the longer aliphatic side chain at the quinolone ring showed stronger inhibition of NFAT activity. These N-methylated compounds showed comparable inhibitory effects against NF-kappa B activity. However, quinolone alkaloids without the N-methyl group showed a more selective inhibition of NFAT activity. SN - 0918-6158 UR - https://www.unboundmedicine.com/medline/citation/15187449/Quinolone_alkaloids_with_inhibitory_activity_against_nuclear_factor_of_activated_T_cells_from_the_fruits_of_Evodia_rutaecarpa_ DB - PRIME DP - Unbound Medicine ER -