Tags

Type your tag names separated by a space and hit enter

Differential response to alcohol in light and moderate female social drinkers.
Behav Pharmacol. 2004 May; 15(3):167-81.BP

Abstract

Individuals who are moderate drinkers are at increased risk to abuse alcohol. Moreover, women are more vulnerable than men to the adverse consequences of alcohol consumption and recent data indicate that the drinking pattern in women is becoming more similar to that of men. However, few studies have determined whether female moderate drinkers (MD) show a differential response to the subjective and performance effects of alcohol, compared to female light drinkers (LD). Fifteen female MD who consumed an average of 34.7 drinks/month were compared to 15 female LD who consumed an average of 6.7 drinks/month. None of the participants had a first-degree family history of alcoholism or substance abuse. The acute effects of alcohol (0, 0.25, 0.50, 0.75 mg/kg) were evaluated using a double-blind, placebo-controlled outpatient design. Drug effects were assessed using a full range of performance measures, subjective-effects questionnaires and observer ratings. Alcohol impaired performance in a dose-related manner on all performance tasks for both groups of females. However, MD were less impaired than LD on balance and Digit Symbol Substitution Test (DSST). This reduced response was also evident from the observer ratings, with MD being viewed as less impaired by alcohol than LD. While ratings of Drug Liking increased in both groups of women on the ascending limb of the breath alcohol curve, alcohol was disliked by LD on the descending limb and LD reported increased ratings of Bad Drug Effects following the high dose of alcohol. The reduced performance impairment, coupled with the positive subjective effects and relative absence of adverse subjective effects, suggestive of behavioral tolerance, could result in a progression towards increased alcohol consumption among moderate female social drinkers.

Authors+Show Affiliations

New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York 10032, USA. se18@columbia.eduNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15187575

Citation

Evans, S M., and F R. Levin. "Differential Response to Alcohol in Light and Moderate Female Social Drinkers." Behavioural Pharmacology, vol. 15, no. 3, 2004, pp. 167-81.
Evans SM, Levin FR. Differential response to alcohol in light and moderate female social drinkers. Behav Pharmacol. 2004;15(3):167-81.
Evans, S. M., & Levin, F. R. (2004). Differential response to alcohol in light and moderate female social drinkers. Behavioural Pharmacology, 15(3), 167-81.
Evans SM, Levin FR. Differential Response to Alcohol in Light and Moderate Female Social Drinkers. Behav Pharmacol. 2004;15(3):167-81. PubMed PMID: 15187575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential response to alcohol in light and moderate female social drinkers. AU - Evans,S M, AU - Levin,F R, PY - 2004/6/10/pubmed PY - 2004/12/16/medline PY - 2004/6/10/entrez SP - 167 EP - 81 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 15 IS - 3 N2 - Individuals who are moderate drinkers are at increased risk to abuse alcohol. Moreover, women are more vulnerable than men to the adverse consequences of alcohol consumption and recent data indicate that the drinking pattern in women is becoming more similar to that of men. However, few studies have determined whether female moderate drinkers (MD) show a differential response to the subjective and performance effects of alcohol, compared to female light drinkers (LD). Fifteen female MD who consumed an average of 34.7 drinks/month were compared to 15 female LD who consumed an average of 6.7 drinks/month. None of the participants had a first-degree family history of alcoholism or substance abuse. The acute effects of alcohol (0, 0.25, 0.50, 0.75 mg/kg) were evaluated using a double-blind, placebo-controlled outpatient design. Drug effects were assessed using a full range of performance measures, subjective-effects questionnaires and observer ratings. Alcohol impaired performance in a dose-related manner on all performance tasks for both groups of females. However, MD were less impaired than LD on balance and Digit Symbol Substitution Test (DSST). This reduced response was also evident from the observer ratings, with MD being viewed as less impaired by alcohol than LD. While ratings of Drug Liking increased in both groups of women on the ascending limb of the breath alcohol curve, alcohol was disliked by LD on the descending limb and LD reported increased ratings of Bad Drug Effects following the high dose of alcohol. The reduced performance impairment, coupled with the positive subjective effects and relative absence of adverse subjective effects, suggestive of behavioral tolerance, could result in a progression towards increased alcohol consumption among moderate female social drinkers. SN - 0955-8810 UR - https://www.unboundmedicine.com/medline/citation/15187575/Differential_response_to_alcohol_in_light_and_moderate_female_social_drinkers_ L2 - http://Insights.ovid.com/pubmed?pmid=15187575 DB - PRIME DP - Unbound Medicine ER -