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Vitamin B12 deficiency as a worldwide problem.
Annu Rev Nutr. 2004; 24:299-326.AR

Abstract

Pernicious anemia is a common cause of megaloblastic anemia throughout the world and especially in persons of European or African descent. Dietary deficiency of vitamin B12 due to vegetarianism is increasing and causes hyperhomocysteinemia. The breast-fed infant of a vitamin B12-deficient mother is at risk for severe developmental abnormalities, growth failure, and anemia. Elevated methylmalonic acid and/or total homocysteine are sensitive indicators of vitamin B12-deficient diets and correlate with clinical abnormalities. Dietary vitamin B12 deficiency is a severe problem in the Indian subcontinent, Mexico, Central and South America, and selected areas in Africa. Dietary vitamin B12 deficiency is not prevalent in Asia, except in vegetarians. Areas for research include intermittent vitamin B12 supplement dosing and better measurements of the bioavailability of B12 in fermented vegetarian foods and algae.

Authors+Show Affiliations

Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. Sally.Stabler@UCHSC.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15189123

Citation

Stabler, Sally P., and Robert H. Allen. "Vitamin B12 Deficiency as a Worldwide Problem." Annual Review of Nutrition, vol. 24, 2004, pp. 299-326.
Stabler SP, Allen RH. Vitamin B12 deficiency as a worldwide problem. Annu Rev Nutr. 2004;24:299-326.
Stabler, S. P., & Allen, R. H. (2004). Vitamin B12 deficiency as a worldwide problem. Annual Review of Nutrition, 24, 299-326.
Stabler SP, Allen RH. Vitamin B12 Deficiency as a Worldwide Problem. Annu Rev Nutr. 2004;24:299-326. PubMed PMID: 15189123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin B12 deficiency as a worldwide problem. AU - Stabler,Sally P, AU - Allen,Robert H, PY - 2004/6/11/pubmed PY - 2004/11/2/medline PY - 2004/6/11/entrez SP - 299 EP - 326 JF - Annual review of nutrition JO - Annu Rev Nutr VL - 24 N2 - Pernicious anemia is a common cause of megaloblastic anemia throughout the world and especially in persons of European or African descent. Dietary deficiency of vitamin B12 due to vegetarianism is increasing and causes hyperhomocysteinemia. The breast-fed infant of a vitamin B12-deficient mother is at risk for severe developmental abnormalities, growth failure, and anemia. Elevated methylmalonic acid and/or total homocysteine are sensitive indicators of vitamin B12-deficient diets and correlate with clinical abnormalities. Dietary vitamin B12 deficiency is a severe problem in the Indian subcontinent, Mexico, Central and South America, and selected areas in Africa. Dietary vitamin B12 deficiency is not prevalent in Asia, except in vegetarians. Areas for research include intermittent vitamin B12 supplement dosing and better measurements of the bioavailability of B12 in fermented vegetarian foods and algae. SN - 0199-9885 UR - https://www.unboundmedicine.com/medline/citation/15189123/Vitamin_B12_deficiency_as_a_worldwide_problem_ L2 - https://arjournals.annualreviews.org/doi/10.1146/annurev.nutr.24.012003.132440?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -