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Antimicrobial activity of isocytisoside and extracts of Aquilegia vulgaris L.
Lett Appl Microbiol. 2004; 39(1):93-7.LA

Abstract

AIMS

The aim of this study was to analyse the antimicrobial properties extracts of Aquilegia vulgaris, and their principial flavonoid component and to compare the obtained results with the activity of gentamicin and nystatin.

METHODS AND RESULTS

The ethanol, acetone and isopropanol extracts as well as the subextracts isolated from the methanol extract together with the main flavonoid: 4'-methoxy-5,7-dihydroxyflavone 6-C-glucoside (isocytisoside) were obtained from the leaves with stems of Aquilegia vulgaris L. All the extracts were analysed by TLC to confirm flavonoids and phenolic acids occurrence. The antimicrobial activity was tested by the method of series dilutions against different Gram-positive, Gram-negative bacteria and also fungi. The results have shown that the extracts, subextracts and isocytisoside inhibit growth of all studied micro-organisms, revealing the greatest activity against Gram-positive Staphylococcus aureus, Staph. epidermidis and the mould Aspergillus niger.

CONCLUSIONS

The antimicrobial activity of the tested materials it is possibly related to the content of isocytisoside.

SIGNIFICANCE AND IMPACT OF THE STUDY

This study has determined new activity of A. vulgaris and suggested the necessity of further studies.

Authors+Show Affiliations

Department of Pharmacognosy, University of Medical Sciences in Poznan, Poznan, Poland. wieslawabylka@o2.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15189294

Citation

Bylka, W, et al. "Antimicrobial Activity of Isocytisoside and Extracts of Aquilegia Vulgaris L." Letters in Applied Microbiology, vol. 39, no. 1, 2004, pp. 93-7.
Bylka W, Szaufer-Hajdrych M, Matławska I, et al. Antimicrobial activity of isocytisoside and extracts of Aquilegia vulgaris L. Lett Appl Microbiol. 2004;39(1):93-7.
Bylka, W., Szaufer-Hajdrych, M., Matławska, I., & Goślińska, O. (2004). Antimicrobial activity of isocytisoside and extracts of Aquilegia vulgaris L. Letters in Applied Microbiology, 39(1), 93-7.
Bylka W, et al. Antimicrobial Activity of Isocytisoside and Extracts of Aquilegia Vulgaris L. Lett Appl Microbiol. 2004;39(1):93-7. PubMed PMID: 15189294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial activity of isocytisoside and extracts of Aquilegia vulgaris L. AU - Bylka,W, AU - Szaufer-Hajdrych,M, AU - Matławska,I, AU - Goślińska,O, PY - 2004/6/11/pubmed PY - 2004/9/4/medline PY - 2004/6/11/entrez SP - 93 EP - 7 JF - Letters in applied microbiology JO - Lett Appl Microbiol VL - 39 IS - 1 N2 - AIMS: The aim of this study was to analyse the antimicrobial properties extracts of Aquilegia vulgaris, and their principial flavonoid component and to compare the obtained results with the activity of gentamicin and nystatin. METHODS AND RESULTS: The ethanol, acetone and isopropanol extracts as well as the subextracts isolated from the methanol extract together with the main flavonoid: 4'-methoxy-5,7-dihydroxyflavone 6-C-glucoside (isocytisoside) were obtained from the leaves with stems of Aquilegia vulgaris L. All the extracts were analysed by TLC to confirm flavonoids and phenolic acids occurrence. The antimicrobial activity was tested by the method of series dilutions against different Gram-positive, Gram-negative bacteria and also fungi. The results have shown that the extracts, subextracts and isocytisoside inhibit growth of all studied micro-organisms, revealing the greatest activity against Gram-positive Staphylococcus aureus, Staph. epidermidis and the mould Aspergillus niger. CONCLUSIONS: The antimicrobial activity of the tested materials it is possibly related to the content of isocytisoside. SIGNIFICANCE AND IMPACT OF THE STUDY: This study has determined new activity of A. vulgaris and suggested the necessity of further studies. SN - 0266-8254 UR - https://www.unboundmedicine.com/medline/citation/15189294/Antimicrobial_activity_of_isocytisoside_and_extracts_of_Aquilegia_vulgaris_L_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0266-8254&date=2004&volume=39&issue=1&spage=93 DB - PRIME DP - Unbound Medicine ER -