Tags

Type your tag names separated by a space and hit enter

The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
Eur J Pharmacol. 2004 Jun 16; 493(1-3):65-74.EJ

Abstract

Our study addressed the hypothesis that spinal release of endogenous opioids underlies Delta9-tetrahydrocannabinol (Delta9-THC)-induced antinociception in Freund's adjuvant-induced arthritic and nonarthritic rats. The paw-pressure test was used to assess the antinociceptive effects of Delta9-THC versus those of morphine, and opioid and cannabinoid receptor-selective antagonists were used to characterize the involved receptors. Cerebrospinal fluid was collected after Delta9-THC injection (i.p.) for the measurement of endogenous opioid peptides. Our results indicate that morphine or Delta9-THC is equally potent and efficacious in both nonarthritic and arthritic rats. Delta9-THC-induced antinociception is attenuated by the kappa opioid receptor antagonist, nor-binaltorphimine, in arthritic rats only. Delta9-THC induces increased immunoreactive dynorphin A (idyn A) levels in nonarthritic rats while decreasing idyn A in arthritic rats. We hypothesize that the elevated idyn A level in arthritic rats contributes to hyperalgesia by interaction with N-methyl-D-aspartate receptors, and that Delta9-THC induces antinociception by decreasing idyn A release.

Authors+Show Affiliations

Virginia Commonwealth University, Department of Pharmacology and Toxicology, Medical College of Virginia, P.O. Box 980613, MCV Station, Richmond, VA 23298-0613, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15189765

Citation

Cox, Melinda L., and Sandra P. Welch. "The Antinociceptive Effect of Delta9-tetrahydrocannabinol in the Arthritic Rat." European Journal of Pharmacology, vol. 493, no. 1-3, 2004, pp. 65-74.
Cox ML, Welch SP. The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat. Eur J Pharmacol. 2004;493(1-3):65-74.
Cox, M. L., & Welch, S. P. (2004). The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat. European Journal of Pharmacology, 493(1-3), 65-74.
Cox ML, Welch SP. The Antinociceptive Effect of Delta9-tetrahydrocannabinol in the Arthritic Rat. Eur J Pharmacol. 2004 Jun 16;493(1-3):65-74. PubMed PMID: 15189765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat. AU - Cox,Melinda L, AU - Welch,Sandra P, PY - 2003/12/10/received PY - 2004/03/24/revised PY - 2004/04/09/accepted PY - 2004/6/11/pubmed PY - 2005/3/1/medline PY - 2004/6/11/entrez SP - 65 EP - 74 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 493 IS - 1-3 N2 - Our study addressed the hypothesis that spinal release of endogenous opioids underlies Delta9-tetrahydrocannabinol (Delta9-THC)-induced antinociception in Freund's adjuvant-induced arthritic and nonarthritic rats. The paw-pressure test was used to assess the antinociceptive effects of Delta9-THC versus those of morphine, and opioid and cannabinoid receptor-selective antagonists were used to characterize the involved receptors. Cerebrospinal fluid was collected after Delta9-THC injection (i.p.) for the measurement of endogenous opioid peptides. Our results indicate that morphine or Delta9-THC is equally potent and efficacious in both nonarthritic and arthritic rats. Delta9-THC-induced antinociception is attenuated by the kappa opioid receptor antagonist, nor-binaltorphimine, in arthritic rats only. Delta9-THC induces increased immunoreactive dynorphin A (idyn A) levels in nonarthritic rats while decreasing idyn A in arthritic rats. We hypothesize that the elevated idyn A level in arthritic rats contributes to hyperalgesia by interaction with N-methyl-D-aspartate receptors, and that Delta9-THC induces antinociception by decreasing idyn A release. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/15189765/The_antinociceptive_effect_of_Delta9_tetrahydrocannabinol_in_the_arthritic_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014299904004078 DB - PRIME DP - Unbound Medicine ER -