[Role of immediate hypersensitivity to airborne allergens in the pathogenesis of atopic dermatitis].Pol Merkur Lekarski. 2004 Mar; 16(93):245-50.PM
Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with hyperproduction of immunoglobulin E directed against common environmental allergens.
The aim of the study was to evaluate the immediate type of immunological reaction indicated by airborne allergens in the pathomechanism of atopic dermatitis.
MATERIAL AND METHODS
529 patients with AD aged (0.5-60 years) who fulfilled basic Hanifin and Rajka criterias and 60 healthy volunteers in the control group were investigated. In order to evaluate IgE-mediated allergy to common airborne and alimentary allergens skin prick tests (SPT) were performed (26 airborne and 7 basic alimentary allergens) and concentration of serum antigen specific IgE (asigE) was measured.
Our results indicated airborne allergy in case of 405 patients (76.6%) and food allergy only in 67 cases (12.7%). In the group of children aged 0.5-4 years food allergy was predominant but later on the predominance of airborne allergy was observed.
We conclude that airborne allergy plays an important and predominant role in the pathomechanism of atopic dermatitis.