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Pancreatic carcinoma with brain metastases: case report and literature review.
Dig Liver Dis. 2004 May; 36(5):355-60.DL

Abstract

The case of a patient developing multiple brain metastases from carcinoma of the exocrine pancreas has been described. A 56-year-old man with stage IV pancreatic cancer attained a clinical and radiographic response while receiving the G-FLIP chemotherapy regimen (biweekly gemcitabine, irinotecan, 5-fluorouracil, leucovorin and cisplatin). After 4 months of therapy, he developed gait imbalance and weakness in the right hand. An MRI of the brain showed multiple 1-2 mm enhancing nodules in the cerebral hemispheres and pons. A subsequent biopsy confirmed that these were pancreatic carcinoma metastases. The patient experienced a rapid deterioration in his neurological status and died 3 days after brain biopsy. Previously reported cases of brain metastases from pancreatic cancer are reviewed.

Authors+Show Affiliations

St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians & Surgeons, 1000 Tenth Avenue, Suite 11 G, New York, NY 10019, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

15191206

Citation

El Kamar, F G., et al. "Pancreatic Carcinoma With Brain Metastases: Case Report and Literature Review." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 36, no. 5, 2004, pp. 355-60.
El Kamar FG, Jindal K, Grossbard ML, et al. Pancreatic carcinoma with brain metastases: case report and literature review. Dig Liver Dis. 2004;36(5):355-60.
El Kamar, F. G., Jindal, K., Grossbard, M. L., Mizrachi, H. H., & Kozuch, P. S. (2004). Pancreatic carcinoma with brain metastases: case report and literature review. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 36(5), 355-60.
El Kamar FG, et al. Pancreatic Carcinoma With Brain Metastases: Case Report and Literature Review. Dig Liver Dis. 2004;36(5):355-60. PubMed PMID: 15191206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic carcinoma with brain metastases: case report and literature review. AU - El Kamar,F G, AU - Jindal,K, AU - Grossbard,M L, AU - Mizrachi,H H, AU - Kozuch,P S, PY - 2004/6/12/pubmed PY - 2004/9/24/medline PY - 2004/6/12/entrez SP - 355 EP - 60 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 36 IS - 5 N2 - The case of a patient developing multiple brain metastases from carcinoma of the exocrine pancreas has been described. A 56-year-old man with stage IV pancreatic cancer attained a clinical and radiographic response while receiving the G-FLIP chemotherapy regimen (biweekly gemcitabine, irinotecan, 5-fluorouracil, leucovorin and cisplatin). After 4 months of therapy, he developed gait imbalance and weakness in the right hand. An MRI of the brain showed multiple 1-2 mm enhancing nodules in the cerebral hemispheres and pons. A subsequent biopsy confirmed that these were pancreatic carcinoma metastases. The patient experienced a rapid deterioration in his neurological status and died 3 days after brain biopsy. Previously reported cases of brain metastases from pancreatic cancer are reviewed. SN - 1590-8658 UR - https://www.unboundmedicine.com/medline/citation/15191206/Pancreatic_carcinoma_with_brain_metastases:_case_report_and_literature_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(04)00053-2 DB - PRIME DP - Unbound Medicine ER -