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Carditis in patients with gastro-oesophageal reflux disease: results of a controlled study based on both endoscopy and 24-h oesophageal pH monitoring.
Aliment Pharmacol Ther 2004; 19(12):1285-92AP

Abstract

BACKGROUND

There are conflicting reports on the role of gastro-oesophageal reflux disease (GERD) and Helicobacter pylori infection in the aetiology of carditis.

AIM

The role of reflux and H. pylori infection in causing carditis was assessed in 113 consecutive patients with GERD and in 25 controls.

METHODS

All subjects underwent endoscopy and pH test and carditis was diagnosed on biopsies taken across the squamocolumnar junction. Helicobacter pylori was assessed by histology and rapid urease test. GERD was diagnosed by endoscopic oesophagitis or abnormal pH test.

RESULTS

Carditis was detected in 53 of 71 GERD patients and in 15 of 20 controls. Among patients, 18 showed absent, 39 mild and 14 marked cardia inflammation and their H. pylori infection rates were 17, 23 and 57%, respectively (P < 0.025). Most patients with carditis (68%) lacked H. pylori infection. pH-metry was abnormal in 15 of 18 patients with normal cardia, 33 of 39 with mild carditis and 12 of 14 with marked inflammation.

CONCLUSIONS

Carditis is a frequent finding in GERD and controls. Mild, non-active carditis is frequent in GERD patients. Marked inflammation is associated with both H. pylori and abnormal pH testing. Thus, both GERD and H. pylori infection may play a role in inducing carditis.

Authors+Show Affiliations

Dipartimento di Medicina Interna e Specialita Mediche, University of Genoa, Genoa, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15191510

Citation

Zentilin, P, et al. "Carditis in Patients With Gastro-oesophageal Reflux Disease: Results of a Controlled Study Based On Both Endoscopy and 24-h Oesophageal pH Monitoring." Alimentary Pharmacology & Therapeutics, vol. 19, no. 12, 2004, pp. 1285-92.
Zentilin P, Mastracci L, Dulbecco P, et al. Carditis in patients with gastro-oesophageal reflux disease: results of a controlled study based on both endoscopy and 24-h oesophageal pH monitoring. Aliment Pharmacol Ther. 2004;19(12):1285-92.
Zentilin, P., Mastracci, L., Dulbecco, P., Gambaro, C., Bilardi, C., Ceppa, P., ... Savarino, V. (2004). Carditis in patients with gastro-oesophageal reflux disease: results of a controlled study based on both endoscopy and 24-h oesophageal pH monitoring. Alimentary Pharmacology & Therapeutics, 19(12), pp. 1285-92.
Zentilin P, et al. Carditis in Patients With Gastro-oesophageal Reflux Disease: Results of a Controlled Study Based On Both Endoscopy and 24-h Oesophageal pH Monitoring. Aliment Pharmacol Ther. 2004 Jun 15;19(12):1285-92. PubMed PMID: 15191510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carditis in patients with gastro-oesophageal reflux disease: results of a controlled study based on both endoscopy and 24-h oesophageal pH monitoring. AU - Zentilin,P, AU - Mastracci,L, AU - Dulbecco,P, AU - Gambaro,C, AU - Bilardi,C, AU - Ceppa,P, AU - Spaggiari,P, AU - Iiritano,E, AU - Mansi,C, AU - Vigneri,S, AU - Fiocca,R, AU - Savarino,V, PY - 2004/6/12/pubmed PY - 2004/10/13/medline PY - 2004/6/12/entrez SP - 1285 EP - 92 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 19 IS - 12 N2 - BACKGROUND: There are conflicting reports on the role of gastro-oesophageal reflux disease (GERD) and Helicobacter pylori infection in the aetiology of carditis. AIM: The role of reflux and H. pylori infection in causing carditis was assessed in 113 consecutive patients with GERD and in 25 controls. METHODS: All subjects underwent endoscopy and pH test and carditis was diagnosed on biopsies taken across the squamocolumnar junction. Helicobacter pylori was assessed by histology and rapid urease test. GERD was diagnosed by endoscopic oesophagitis or abnormal pH test. RESULTS: Carditis was detected in 53 of 71 GERD patients and in 15 of 20 controls. Among patients, 18 showed absent, 39 mild and 14 marked cardia inflammation and their H. pylori infection rates were 17, 23 and 57%, respectively (P < 0.025). Most patients with carditis (68%) lacked H. pylori infection. pH-metry was abnormal in 15 of 18 patients with normal cardia, 33 of 39 with mild carditis and 12 of 14 with marked inflammation. CONCLUSIONS: Carditis is a frequent finding in GERD and controls. Mild, non-active carditis is frequent in GERD patients. Marked inflammation is associated with both H. pylori and abnormal pH testing. Thus, both GERD and H. pylori infection may play a role in inducing carditis. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/15191510/Carditis_in_patients_with_gastro_oesophageal_reflux_disease:_results_of_a_controlled_study_based_on_both_endoscopy_and_24_h_oesophageal_pH_monitoring_ L2 - https://doi.org/10.1111/j.1365-2036.2004.02000.x DB - PRIME DP - Unbound Medicine ER -