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Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies.

Abstract

It has been proposed that maternal nutrient restriction may alter the functional development of the adipocyte and the synthesis and secretion of the adipocyte-derived hormone, leptin, before birth. We have investigated the effects of restricted periconceptional undernutrition and/or restricted gestational nutrition on fetal plasma leptin concentrations and fetal adiposity in late gestation. There was no effect of either restricted periconceptional or gestational nutrition on maternal or fetal plasma leptin concentrations in singleton or twin pregnancies during late gestation. In ewes carrying twins, but not singletons, maternal plasma leptin concentrations in late gestation were directly related to the change in ewe weight that occurred during the 60 days before mating [maternal leptin = 0.9 (change in ewe weight) + 7.8; r = 0.6, P < 0.05]. In twin, but not singleton, pregnancies, there was also a significant relationship between maternal and fetal leptin concentrations (maternal leptin = 0.5 fetal leptin + 4.2, r = 0.63, P < 0.005). The relative mass of perirenal fat was also significantly increased in twin fetal sheep in the control-restricted group (6.0 +/- 0.5) compared with the other nutritional groups (control-control: 4.1 +/- 0.4; restricted-restricted: 4.4 +/- 0.4; restricted-control: 4.3 +/- 0.3). In conclusion, the impact of maternal undernutrition on maternal plasma leptin concentrations during late gestation is dependent on fetal number. Furthermore, we have found that there is an increased fetal adiposity in the twins of ewes that experienced restricted nutrition throughout gestation, and this may be important in the programming of postnatal adiposity.

Authors+Show Affiliations

Discipline of Physiology, School of Molecular and Biomedical Sciences, University of Adelaide, South Australia. lisa.edwards@adelaide.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15191901

Citation

Edwards, L J., et al. "Impact of Periconceptional Nutrition On Maternal and Fetal Leptin and Fetal Adiposity in Singleton and Twin Pregnancies." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, vol. 288, no. 1, 2005, pp. R39-45.
Edwards LJ, McFarlane JR, Kauter KG, et al. Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies. Am J Physiol Regul Integr Comp Physiol. 2005;288(1):R39-45.
Edwards, L. J., McFarlane, J. R., Kauter, K. G., & McMillen, I. C. (2005). Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 288(1), pp. R39-45.
Edwards LJ, et al. Impact of Periconceptional Nutrition On Maternal and Fetal Leptin and Fetal Adiposity in Singleton and Twin Pregnancies. Am J Physiol Regul Integr Comp Physiol. 2005;288(1):R39-45. PubMed PMID: 15191901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies. AU - Edwards,L J, AU - McFarlane,J R, AU - Kauter,K G, AU - McMillen,I C, Y1 - 2004/06/10/ PY - 2004/6/12/pubmed PY - 2005/3/3/medline PY - 2004/6/12/entrez SP - R39 EP - 45 JF - American journal of physiology. Regulatory, integrative and comparative physiology JO - Am. J. Physiol. Regul. Integr. Comp. Physiol. VL - 288 IS - 1 N2 - It has been proposed that maternal nutrient restriction may alter the functional development of the adipocyte and the synthesis and secretion of the adipocyte-derived hormone, leptin, before birth. We have investigated the effects of restricted periconceptional undernutrition and/or restricted gestational nutrition on fetal plasma leptin concentrations and fetal adiposity in late gestation. There was no effect of either restricted periconceptional or gestational nutrition on maternal or fetal plasma leptin concentrations in singleton or twin pregnancies during late gestation. In ewes carrying twins, but not singletons, maternal plasma leptin concentrations in late gestation were directly related to the change in ewe weight that occurred during the 60 days before mating [maternal leptin = 0.9 (change in ewe weight) + 7.8; r = 0.6, P < 0.05]. In twin, but not singleton, pregnancies, there was also a significant relationship between maternal and fetal leptin concentrations (maternal leptin = 0.5 fetal leptin + 4.2, r = 0.63, P < 0.005). The relative mass of perirenal fat was also significantly increased in twin fetal sheep in the control-restricted group (6.0 +/- 0.5) compared with the other nutritional groups (control-control: 4.1 +/- 0.4; restricted-restricted: 4.4 +/- 0.4; restricted-control: 4.3 +/- 0.3). In conclusion, the impact of maternal undernutrition on maternal plasma leptin concentrations during late gestation is dependent on fetal number. Furthermore, we have found that there is an increased fetal adiposity in the twins of ewes that experienced restricted nutrition throughout gestation, and this may be important in the programming of postnatal adiposity. SN - 0363-6119 UR - https://www.unboundmedicine.com/medline/citation/15191901/Impact_of_periconceptional_nutrition_on_maternal_and_fetal_leptin_and_fetal_adiposity_in_singleton_and_twin_pregnancies_ L2 - http://www.physiology.org/doi/full/10.1152/ajpregu.00127.2004?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -