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Polymorphisms in the estrogen receptor beta gene but not estrogen receptor alpha gene affect the risk of developing endometriosis in a Japanese population.
Fertil Steril. 2004 Jun; 81(6):1650-6.FS

Abstract

OBJECTIVE

To determine whether polymorphisms in the estrogen receptor (ER) alpha and beta genes are associated with endometriosis in a Japanese population.

DESIGN

Association study.

SETTING

University hospital.

PATIENT(S)

Japanese women diagnosed with endometriosis by laparotomy or laparoscopy.

INTERVENTION(S)

Determination of polymorphisms in the ERalpha and ERbeta genes was performed by polymerase chain reaction restriction fragment-length polymorphism analysis in 132 affected women and 182 controls.

MAIN OUTCOME MEASURE(S)

Frequency and distribution of AluI and RsaI polymorphisms in ERbeta gene and of PvuII and XbaI polymorphisms in ERalpha gene.

RESULT(S)

No significant differences in the frequency of either AluI and RsaI polymorphisms in the ERbeta gene or of XbaI and PvuII polymorphisms in the ERalpha gene were found between endometriosis patients and controls. However, a positive association was noted between the AluI polymorphism in the ERbeta gene and stage IV endometriosis patients in the population studied.

CONCLUSION(S)

The AluI polymorphism in the ERbeta gene is associated with an increased risk of stage IV endometriosis in a Japanese population.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15193490

Citation

Wang, Zhuo, et al. "Polymorphisms in the Estrogen Receptor Beta Gene but Not Estrogen Receptor Alpha Gene Affect the Risk of Developing Endometriosis in a Japanese Population." Fertility and Sterility, vol. 81, no. 6, 2004, pp. 1650-6.
Wang Z, Yoshida S, Negoro K, et al. Polymorphisms in the estrogen receptor beta gene but not estrogen receptor alpha gene affect the risk of developing endometriosis in a Japanese population. Fertil Steril. 2004;81(6):1650-6.
Wang, Z., Yoshida, S., Negoro, K., Kennedy, S., Barlow, D., & Maruo, T. (2004). Polymorphisms in the estrogen receptor beta gene but not estrogen receptor alpha gene affect the risk of developing endometriosis in a Japanese population. Fertility and Sterility, 81(6), 1650-6.
Wang Z, et al. Polymorphisms in the Estrogen Receptor Beta Gene but Not Estrogen Receptor Alpha Gene Affect the Risk of Developing Endometriosis in a Japanese Population. Fertil Steril. 2004;81(6):1650-6. PubMed PMID: 15193490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphisms in the estrogen receptor beta gene but not estrogen receptor alpha gene affect the risk of developing endometriosis in a Japanese population. AU - Wang,Zhuo, AU - Yoshida,Shigeki, AU - Negoro,Kenichi, AU - Kennedy,Stephen, AU - Barlow,David, AU - Maruo,Takeshi, PY - 2003/10/09/received PY - 2004/02/21/revised PY - 2004/02/21/accepted PY - 2004/6/15/pubmed PY - 2004/7/15/medline PY - 2004/6/15/entrez SP - 1650 EP - 6 JF - Fertility and sterility JO - Fertil Steril VL - 81 IS - 6 N2 - OBJECTIVE: To determine whether polymorphisms in the estrogen receptor (ER) alpha and beta genes are associated with endometriosis in a Japanese population. DESIGN: Association study. SETTING: University hospital. PATIENT(S): Japanese women diagnosed with endometriosis by laparotomy or laparoscopy. INTERVENTION(S): Determination of polymorphisms in the ERalpha and ERbeta genes was performed by polymerase chain reaction restriction fragment-length polymorphism analysis in 132 affected women and 182 controls. MAIN OUTCOME MEASURE(S): Frequency and distribution of AluI and RsaI polymorphisms in ERbeta gene and of PvuII and XbaI polymorphisms in ERalpha gene. RESULT(S): No significant differences in the frequency of either AluI and RsaI polymorphisms in the ERbeta gene or of XbaI and PvuII polymorphisms in the ERalpha gene were found between endometriosis patients and controls. However, a positive association was noted between the AluI polymorphism in the ERbeta gene and stage IV endometriosis patients in the population studied. CONCLUSION(S): The AluI polymorphism in the ERbeta gene is associated with an increased risk of stage IV endometriosis in a Japanese population. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/15193490/Polymorphisms_in_the_estrogen_receptor_beta_gene_but_not_estrogen_receptor_alpha_gene_affect_the_risk_of_developing_endometriosis_in_a_Japanese_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015028204005035 DB - PRIME DP - Unbound Medicine ER -