Tags

Type your tag names separated by a space and hit enter

Cost effectiveness of alendronate for the treatment of male osteoporosis in Sweden.
Bone. 2004 Jun; 34(6):1064-71.BONE

Abstract

BACKGROUND

One third of all the hip fractures occur in men. The risk for mortality following hip fracture is higher for men compared to women. The Fracture Intervention Trial (FIT) showed that the bisphosphonate alendronate reduces the risk of fractures and increases bone mineral density (BMD) in osteoporotic women. Similar effects of alendronate were observed in men in some other trials. There are also results demonstrating alendronate to be cost-effective in the treatment of osteoporosis in women.

OBJECTIVE

To investigate the cost effectiveness of alendronate for male osteoporosis in Sweden by assuming the same relative risk reduction of fractures in men as for women, based on the FIT trial.

DESIGN

A Markov model earlier used to analyze cost effectiveness of alendronate in treatment of postmenopausal osteoporosis in Sweden was adapted to fit a cohort of Swedish men. Cost effectiveness of alendronate vs. no treatment was assessed by transitioning men in the model over time between different health states.

TIME HORIZON

The patients were followed from start of intervention until 100 years of age or death. In the base-case alendronate was assumed to have a fracture-risk-reducing effect for 10 years; a treatment duration period of 5 years followed by a 5-year period where the effect declined linearly to zero.

RESULTS

Taking a societal perspective treating a 71-year-old man (mean age in the FIT) with low BMD and prior vertebral fracture (VFA) with alendronate was found to be associated with a cost of 14,843 per quality adjusted life year (QALY) gained.

CONCLUSIONS

The results in this study indicate that treating osteoporotic men with alendronate was projected to be cost-effective, under the assumption of the same fracture-risk-reducing effect of alendronate for men as for women.

Authors+Show Affiliations

Stockholm Health Economics, Sweden. frederick.b@healtheconomics.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15193554

Citation

Borgström, Fredrik, et al. "Cost Effectiveness of Alendronate for the Treatment of Male Osteoporosis in Sweden." Bone, vol. 34, no. 6, 2004, pp. 1064-71.
Borgström F, Johnell O, Jönsson B, et al. Cost effectiveness of alendronate for the treatment of male osteoporosis in Sweden. Bone. 2004;34(6):1064-71.
Borgström, F., Johnell, O., Jönsson, B., Zethraeus, N., & Sen, S. S. (2004). Cost effectiveness of alendronate for the treatment of male osteoporosis in Sweden. Bone, 34(6), 1064-71.
Borgström F, et al. Cost Effectiveness of Alendronate for the Treatment of Male Osteoporosis in Sweden. Bone. 2004;34(6):1064-71. PubMed PMID: 15193554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cost effectiveness of alendronate for the treatment of male osteoporosis in Sweden. AU - Borgström,Fredrik, AU - Johnell,Olof, AU - Jönsson,Bengt, AU - Zethraeus,Niklas, AU - Sen,Shuvayu S, PY - 2003/05/30/received PY - 2003/12/01/revised PY - 2003/12/03/accepted PY - 2004/6/15/pubmed PY - 2005/1/15/medline PY - 2004/6/15/entrez SP - 1064 EP - 71 JF - Bone JO - Bone VL - 34 IS - 6 N2 - BACKGROUND: One third of all the hip fractures occur in men. The risk for mortality following hip fracture is higher for men compared to women. The Fracture Intervention Trial (FIT) showed that the bisphosphonate alendronate reduces the risk of fractures and increases bone mineral density (BMD) in osteoporotic women. Similar effects of alendronate were observed in men in some other trials. There are also results demonstrating alendronate to be cost-effective in the treatment of osteoporosis in women. OBJECTIVE: To investigate the cost effectiveness of alendronate for male osteoporosis in Sweden by assuming the same relative risk reduction of fractures in men as for women, based on the FIT trial. DESIGN: A Markov model earlier used to analyze cost effectiveness of alendronate in treatment of postmenopausal osteoporosis in Sweden was adapted to fit a cohort of Swedish men. Cost effectiveness of alendronate vs. no treatment was assessed by transitioning men in the model over time between different health states. TIME HORIZON: The patients were followed from start of intervention until 100 years of age or death. In the base-case alendronate was assumed to have a fracture-risk-reducing effect for 10 years; a treatment duration period of 5 years followed by a 5-year period where the effect declined linearly to zero. RESULTS: Taking a societal perspective treating a 71-year-old man (mean age in the FIT) with low BMD and prior vertebral fracture (VFA) with alendronate was found to be associated with a cost of 14,843 per quality adjusted life year (QALY) gained. CONCLUSIONS: The results in this study indicate that treating osteoporotic men with alendronate was projected to be cost-effective, under the assumption of the same fracture-risk-reducing effect of alendronate for men as for women. SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/15193554/Cost_effectiveness_of_alendronate_for_the_treatment_of_male_osteoporosis_in_Sweden_ DB - PRIME DP - Unbound Medicine ER -