Tags

Type your tag names separated by a space and hit enter

Preventive effects of diets supplemented with sweetie fruits in hypercholesterolemic patients suffering from coronary artery disease.
Prev Med. 2004 Jun; 38(6):841-7.PM

Abstract

BACKGROUND

Diets rich in vegetables and fruits prevent development of atherosclerosis.

OBJECTIVE

To investigate the preventive effects of diets supplemented with a new kind of citrus fruit-pummelo-grapefruit hybrid in hypercholesterolemic patients suffering from coronary artery disease (CAD).

SUBJECTS AND METHODS

Sixty-six hypercholesterolemic volunteers after coronary bypass surgery ages 47-68 years were randomly divided into two experimental (EG1 and EG2) groups and one control (CG) group, 22 each. The diets of the patients of the experimental groups (EG1 and EG2) were supplemented with one or two peeled sweeties, respectively. A comprehensive clinical investigation of all 66 patients was done. Blood samples were collected before and after the investigation for a wide range of laboratory tests.

RESULTS

A high content of dietary fibers and antioxidant compounds in peeled sweeties was found. After 30 days of the investigation, peeled sweeties-supplemented diets have decreased plasma lipids levels in EG1 and EG2 vs. CG group: (a) total cholesterol (TC)-7.38 vs. 8.08 mmol/L, - 8.7%, and 6.78 vs. 8.08. mmol/L, -16.1%, respectively; (b) low-density lipoprotein cholesterol (LDL-C)-5.65 vs. 6.39 mmol/L, - 1.6%, and 5.04 vs. 6.39 mmol/L, -21.2%, respectively; (c) triglycerides (TG)-2.01 vs. 2.27 mmol/L, -11.5%, and 1.71 vs. 2.27 mmol/L, -24.7%, respectively. In addition, a significant increase in the plasma antioxidant capacity in EG2, and to a lesser degree in EG1 groups, was observed. No changes in the studied indices in the patients of the CG were detected.

CONCLUSION

Peeled sweeties have high contents of dietary fibers and antioxidant compounds. Diets supplemented with peeled sweeties positively influence plasma lipid metabolism and plasma antioxidant capacity in patients suffering from hypercholesterolemia. Therefore, the addition of peeled sweeties to a generally accepted antiatherosclerotic diet may be beneficial in prevention of atherosclerosis, mainly in hypercholesterolemic patients.

Authors+Show Affiliations

Department of Medicinal Chemistry and Natural Products, The Hebrew University of Jerusalem-Hadassah Medical School, P.O.B. 12065, Jerusalem 91120, Israel. gorin@cc.huji.ac.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15193907

Citation

Gorinstein, Shela, et al. "Preventive Effects of Diets Supplemented With Sweetie Fruits in Hypercholesterolemic Patients Suffering From Coronary Artery Disease." Preventive Medicine, vol. 38, no. 6, 2004, pp. 841-7.
Gorinstein S, Caspi A, Libman I, et al. Preventive effects of diets supplemented with sweetie fruits in hypercholesterolemic patients suffering from coronary artery disease. Prev Med. 2004;38(6):841-7.
Gorinstein, S., Caspi, A., Libman, I., Katrich, E., Lerner, H. T., & Trakhtenberg, S. (2004). Preventive effects of diets supplemented with sweetie fruits in hypercholesterolemic patients suffering from coronary artery disease. Preventive Medicine, 38(6), 841-7.
Gorinstein S, et al. Preventive Effects of Diets Supplemented With Sweetie Fruits in Hypercholesterolemic Patients Suffering From Coronary Artery Disease. Prev Med. 2004;38(6):841-7. PubMed PMID: 15193907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preventive effects of diets supplemented with sweetie fruits in hypercholesterolemic patients suffering from coronary artery disease. AU - Gorinstein,Shela, AU - Caspi,Abraham, AU - Libman,Imanuel, AU - Katrich,Elena, AU - Lerner,Henry Tzvi, AU - Trakhtenberg,Simon, PY - 2004/6/15/pubmed PY - 2004/9/15/medline PY - 2004/6/15/entrez SP - 841 EP - 7 JF - Preventive medicine JO - Prev Med VL - 38 IS - 6 N2 - BACKGROUND: Diets rich in vegetables and fruits prevent development of atherosclerosis. OBJECTIVE: To investigate the preventive effects of diets supplemented with a new kind of citrus fruit-pummelo-grapefruit hybrid in hypercholesterolemic patients suffering from coronary artery disease (CAD). SUBJECTS AND METHODS: Sixty-six hypercholesterolemic volunteers after coronary bypass surgery ages 47-68 years were randomly divided into two experimental (EG1 and EG2) groups and one control (CG) group, 22 each. The diets of the patients of the experimental groups (EG1 and EG2) were supplemented with one or two peeled sweeties, respectively. A comprehensive clinical investigation of all 66 patients was done. Blood samples were collected before and after the investigation for a wide range of laboratory tests. RESULTS: A high content of dietary fibers and antioxidant compounds in peeled sweeties was found. After 30 days of the investigation, peeled sweeties-supplemented diets have decreased plasma lipids levels in EG1 and EG2 vs. CG group: (a) total cholesterol (TC)-7.38 vs. 8.08 mmol/L, - 8.7%, and 6.78 vs. 8.08. mmol/L, -16.1%, respectively; (b) low-density lipoprotein cholesterol (LDL-C)-5.65 vs. 6.39 mmol/L, - 1.6%, and 5.04 vs. 6.39 mmol/L, -21.2%, respectively; (c) triglycerides (TG)-2.01 vs. 2.27 mmol/L, -11.5%, and 1.71 vs. 2.27 mmol/L, -24.7%, respectively. In addition, a significant increase in the plasma antioxidant capacity in EG2, and to a lesser degree in EG1 groups, was observed. No changes in the studied indices in the patients of the CG were detected. CONCLUSION: Peeled sweeties have high contents of dietary fibers and antioxidant compounds. Diets supplemented with peeled sweeties positively influence plasma lipid metabolism and plasma antioxidant capacity in patients suffering from hypercholesterolemia. Therefore, the addition of peeled sweeties to a generally accepted antiatherosclerotic diet may be beneficial in prevention of atherosclerosis, mainly in hypercholesterolemic patients. SN - 0091-7435 UR - https://www.unboundmedicine.com/medline/citation/15193907/Preventive_effects_of_diets_supplemented_with_sweetie_fruits_in_hypercholesterolemic_patients_suffering_from_coronary_artery_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091743504000106 DB - PRIME DP - Unbound Medicine ER -