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Possible role of leptin in hypoandrogenicity in patients with systemic lupus erythematosus and rheumatoid arthritis.
Ann Rheum Dis. 2004 Jul; 63(7):809-16.AR

Abstract

BACKGROUND

Hypoandrogenicity is common in obesity and in chronic inflammatory diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Adrenal androgens such as androstenedione (ASD) and dehydroepiandrosterone (DHEA) sulphate are low, which partly depends on the influence of TNF in chronic inflammatory diseases. Leptin is stimulated by TNF and is associated with hypoandrogenicity in non-inflammatory conditions.

OBJECTIVE

To study the interrelation between serum levels of leptin and adrenal steroids in SLE and RA.

METHODS

In a retrospective study, serum levels of leptin, ASD, DHEA, and 17-hydroxyprogesterone (17OHP) were measured by ELISA, and serum levels of cortisol by radioimmunoassay in 30 patients with RA, 32 with SLE, and 54 healthy control subjects (HS).

RESULTS

In SLE and RA but not HS, serum levels of ASD correlated negatively with serum levels of leptin (p<0.01) independently of prior prednisolone treatment in patients with SLE (p = 0.013) and tended to be independent of prednisolone in patients with RA (p = 0.067). In a partial correlation analysis, this interrelation remained significant after controlling for daily prednisolone dose in both patient groups. In both patient groups, serum leptin levels correlated negatively with the molar ratio of serum ASD/serum cortisol and serum ASD/serum 17OHP, and positively with the molar ratio of serum DHEA/serum ASD.

CONCLUSIONS

The negative correlation of serum leptin and ASD or, particularly, ASD/17OHP, together with its known anti-androgenic effects indicate that leptin is also involved in hypoandrogenicity in patients with SLE and RA. Leptin may be an important link between chronic inflammation and the hypoandrogenic state.

Authors+Show Affiliations

Laboratory of Neuro/endocrino/immunology, Department of Internal Medicine I, University Hospital Regensburg, D-93042 Regensburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15194576

Citation

Härle, P, et al. "Possible Role of Leptin in Hypoandrogenicity in Patients With Systemic Lupus Erythematosus and Rheumatoid Arthritis." Annals of the Rheumatic Diseases, vol. 63, no. 7, 2004, pp. 809-16.
Härle P, Pongratz G, Weidler C, et al. Possible role of leptin in hypoandrogenicity in patients with systemic lupus erythematosus and rheumatoid arthritis. Ann Rheum Dis. 2004;63(7):809-16.
Härle, P., Pongratz, G., Weidler, C., Büttner, R., Schölmerich, J., & Straub, R. H. (2004). Possible role of leptin in hypoandrogenicity in patients with systemic lupus erythematosus and rheumatoid arthritis. Annals of the Rheumatic Diseases, 63(7), 809-16.
Härle P, et al. Possible Role of Leptin in Hypoandrogenicity in Patients With Systemic Lupus Erythematosus and Rheumatoid Arthritis. Ann Rheum Dis. 2004;63(7):809-16. PubMed PMID: 15194576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible role of leptin in hypoandrogenicity in patients with systemic lupus erythematosus and rheumatoid arthritis. AU - Härle,P, AU - Pongratz,G, AU - Weidler,C, AU - Büttner,R, AU - Schölmerich,J, AU - Straub,R H, PY - 2004/6/15/pubmed PY - 2004/8/28/medline PY - 2004/6/15/entrez SP - 809 EP - 16 JF - Annals of the rheumatic diseases JO - Ann Rheum Dis VL - 63 IS - 7 N2 - BACKGROUND: Hypoandrogenicity is common in obesity and in chronic inflammatory diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Adrenal androgens such as androstenedione (ASD) and dehydroepiandrosterone (DHEA) sulphate are low, which partly depends on the influence of TNF in chronic inflammatory diseases. Leptin is stimulated by TNF and is associated with hypoandrogenicity in non-inflammatory conditions. OBJECTIVE: To study the interrelation between serum levels of leptin and adrenal steroids in SLE and RA. METHODS: In a retrospective study, serum levels of leptin, ASD, DHEA, and 17-hydroxyprogesterone (17OHP) were measured by ELISA, and serum levels of cortisol by radioimmunoassay in 30 patients with RA, 32 with SLE, and 54 healthy control subjects (HS). RESULTS: In SLE and RA but not HS, serum levels of ASD correlated negatively with serum levels of leptin (p<0.01) independently of prior prednisolone treatment in patients with SLE (p = 0.013) and tended to be independent of prednisolone in patients with RA (p = 0.067). In a partial correlation analysis, this interrelation remained significant after controlling for daily prednisolone dose in both patient groups. In both patient groups, serum leptin levels correlated negatively with the molar ratio of serum ASD/serum cortisol and serum ASD/serum 17OHP, and positively with the molar ratio of serum DHEA/serum ASD. CONCLUSIONS: The negative correlation of serum leptin and ASD or, particularly, ASD/17OHP, together with its known anti-androgenic effects indicate that leptin is also involved in hypoandrogenicity in patients with SLE and RA. Leptin may be an important link between chronic inflammation and the hypoandrogenic state. SN - 0003-4967 UR - https://www.unboundmedicine.com/medline/citation/15194576/Possible_role_of_leptin_in_hypoandrogenicity_in_patients_with_systemic_lupus_erythematosus_and_rheumatoid_arthritis_ L2 - https://ard.bmj.com/lookup/pmidlookup?view=long&amp;pmid=15194576 DB - PRIME DP - Unbound Medicine ER -