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Assessment of iron status by erythrocyte ferritin in uremic patients with or without recombinant human erythropoietin therapy.
Am J Kidney Dis. 1992 Sep; 20(3):249-54.AJ

Abstract

Erythrocyte ferritin may be a better estimator of iron bioavailability than the conventional markers of iron stores (serum ferritin and transferrin saturation). To investigate the accuracy of these conventional markers in uremic patients compared with erythrocyte ferritin, we studied 29 chronic hemodialysis patients on erythropoietin (EPO) therapy, 18 without EPO therapy, and 22 healthy control subjects. Apart from the red blood cell indices, serum ferritin, transferrin saturation, and erythrocyte ferritin, the analytical study included red blood cell protoporphyrin and plasma aluminum levels. The control group showed erythrocyte ferritin concentrations between 8.3 and 12.5 attograms/cell (95% confidence interval). In the EPO group, red blood cell protoporphyrin correlated negatively with erythrocyte ferritin, but not with serum ferritin or transferrin saturation. In the non-EPO group, serum ferritin, erythrocyte ferritin, and transferrin saturation did not correlate with red blood cell protoporphyrin. Even though erythrocyte ferritin correlated well with serum ferritin in the EPO group (r = 0.61, P = 0.0003), the sensitivity of normal serum ferritin levels (30 to 300 ng/mL) to discard a low erythrocyte ferritin concentration (erythrocyte ferritin less than 7 ag/cell) was 0.53, while the sensitivity of serum ferritin at levels less than 30 ng/mL to indicate an absolute iron deficiency expressed as a low erythrocyte ferritin concentration was 0.28. Only values of serum ferritin and transferrin saturation greater than 300 ng/mL and 35%, respectively, could rule out a relative iron deficiency expressed as a low erythrocyte ferritin and high red blood cell protoporphyrin concentration. Plasma aluminum levels did not correlate with red blood cell protoporphyrin or erythrocyte ferritin levels in either uremic group.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Caravaca F
Nephrology, Service Hospital Infanta Cristina, Extremadura University, Badajoz, Spain.
Vagace JM
No affiliation info available
Aparicio A
No affiliation info available
Groiss J
No affiliation info available
Pizarro JL
No affiliation info available
Alonso N
No affiliation info available
Garcia MC
No affiliation info available
Arrobas M
No affiliation info available
Cubero J
No affiliation info available
Esparrago J
No affiliation info available

MeSH

Anemia, HypochromicErythrocytesErythropoietinFemaleFerritinsHumansIronMaleMiddle AgedProtoporphyrinsRenal DialysisSensitivity and SpecificityTransferrinUremia

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1519605

Citation

Caravaca, F, et al. "Assessment of Iron Status By Erythrocyte Ferritin in Uremic Patients With or Without Recombinant Human Erythropoietin Therapy." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 20, no. 3, 1992, pp. 249-54.
Caravaca F, Vagace JM, Aparicio A, et al. Assessment of iron status by erythrocyte ferritin in uremic patients with or without recombinant human erythropoietin therapy. Am J Kidney Dis. 1992;20(3):249-54.
Caravaca, F., Vagace, J. M., Aparicio, A., Groiss, J., Pizarro, J. L., Alonso, N., Garcia, M. C., Arrobas, M., Cubero, J., & Esparrago, J. (1992). Assessment of iron status by erythrocyte ferritin in uremic patients with or without recombinant human erythropoietin therapy. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 20(3), 249-54.
Caravaca F, et al. Assessment of Iron Status By Erythrocyte Ferritin in Uremic Patients With or Without Recombinant Human Erythropoietin Therapy. Am J Kidney Dis. 1992;20(3):249-54. PubMed PMID: 1519605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of iron status by erythrocyte ferritin in uremic patients with or without recombinant human erythropoietin therapy. A1 - Caravaca,F, AU - Vagace,J M, AU - Aparicio,A, AU - Groiss,J, AU - Pizarro,J L, AU - Alonso,N, AU - Garcia,M C, AU - Arrobas,M, AU - Cubero,J, AU - Esparrago,J, PY - 1992/9/1/pubmed PY - 1992/9/1/medline PY - 1992/9/1/entrez SP - 249 EP - 54 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am J Kidney Dis VL - 20 IS - 3 N2 - Erythrocyte ferritin may be a better estimator of iron bioavailability than the conventional markers of iron stores (serum ferritin and transferrin saturation). To investigate the accuracy of these conventional markers in uremic patients compared with erythrocyte ferritin, we studied 29 chronic hemodialysis patients on erythropoietin (EPO) therapy, 18 without EPO therapy, and 22 healthy control subjects. Apart from the red blood cell indices, serum ferritin, transferrin saturation, and erythrocyte ferritin, the analytical study included red blood cell protoporphyrin and plasma aluminum levels. The control group showed erythrocyte ferritin concentrations between 8.3 and 12.5 attograms/cell (95% confidence interval). In the EPO group, red blood cell protoporphyrin correlated negatively with erythrocyte ferritin, but not with serum ferritin or transferrin saturation. In the non-EPO group, serum ferritin, erythrocyte ferritin, and transferrin saturation did not correlate with red blood cell protoporphyrin. Even though erythrocyte ferritin correlated well with serum ferritin in the EPO group (r = 0.61, P = 0.0003), the sensitivity of normal serum ferritin levels (30 to 300 ng/mL) to discard a low erythrocyte ferritin concentration (erythrocyte ferritin less than 7 ag/cell) was 0.53, while the sensitivity of serum ferritin at levels less than 30 ng/mL to indicate an absolute iron deficiency expressed as a low erythrocyte ferritin concentration was 0.28. Only values of serum ferritin and transferrin saturation greater than 300 ng/mL and 35%, respectively, could rule out a relative iron deficiency expressed as a low erythrocyte ferritin and high red blood cell protoporphyrin concentration. Plasma aluminum levels did not correlate with red blood cell protoporphyrin or erythrocyte ferritin levels in either uremic group.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0272-6386 UR - https://www.unboundmedicine.com/medline/citation/1519605/Assessment_of_iron_status_by_erythrocyte_ferritin_in_uremic_patients_with_or_without_recombinant_human_erythropoietin_therapy_ DB - PRIME DP - Unbound Medicine ER -