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Impact of donor age and year of transplant on graft survival in liver transplant recipients with chronic hepatitis C.

Abstract

Studies suggest donor age and year of transplantation are associated with low graft survival in liver transplant recipients with hepatitis C. We sought to determine if advanced donor age and recent year of transplantation are associated with graft survival in hepatitis C recipients and to determine if the effect of donor age on graft survival is specific to hepatitis C. We analyzed the United Network for Organ Sharing liver transplant database from 1994 to 2002. Six thousand four hundred and four subjects transplanted for end-stage liver disease from chronic hepatitis C met our criteria. One-year graft survival in hepatitis C recipients with organs from donors <40 years old and >or=60 years old was 84% and 73%, p = 0.003, respectively. These rates in recipients with cholestatic liver disease and alcoholic liver disease were 85% and 82%, respectively, p = 0.11 and 82% and 78%, respectively, p = 0.14. Three-year graft survival in hepatitis C recipients transplanted from 1994 to 1995 and 1996 to 1999 was 67% and 69%, respectively, p = 0.10. Graft survival in hepatitis C recipients has not declined in recent years. Older donor age is associated with lower short-term graft survival in recipients with hepatitis C, but not in recipients with cholestatic or alcoholic liver disease.

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  • Authors+Show Affiliations

    ,

    Department of Medicine and the Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA. Mark_Russo@med.unc.edu

    , , , ,

    Source

    MeSH

    Adult
    Age Factors
    Aged
    Databases as Topic
    Female
    Graft Rejection
    Graft Survival
    Hepatitis C
    Humans
    Liver Diseases
    Liver Diseases, Alcoholic
    Liver Transplantation
    Male
    Middle Aged
    Multivariate Analysis
    Time Factors
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15196072

    Citation

    Russo, Mark W., et al. "Impact of Donor Age and Year of Transplant On Graft Survival in Liver Transplant Recipients With Chronic Hepatitis C." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 4, no. 7, 2004, pp. 1133-8.
    Russo MW, Galanko JA, Zacks SL, et al. Impact of donor age and year of transplant on graft survival in liver transplant recipients with chronic hepatitis C. Am J Transplant. 2004;4(7):1133-8.
    Russo, M. W., Galanko, J. A., Zacks, S. L., Beavers, K. L., Fried, M. W., & Shrestha, R. (2004). Impact of donor age and year of transplant on graft survival in liver transplant recipients with chronic hepatitis C. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 4(7), pp. 1133-8.
    Russo MW, et al. Impact of Donor Age and Year of Transplant On Graft Survival in Liver Transplant Recipients With Chronic Hepatitis C. Am J Transplant. 2004;4(7):1133-8. PubMed PMID: 15196072.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Impact of donor age and year of transplant on graft survival in liver transplant recipients with chronic hepatitis C. AU - Russo,Mark W, AU - Galanko,Joseph A, AU - Zacks,Steven L, AU - Beavers,Kimberly L, AU - Fried,Michael W, AU - Shrestha,Roshan, PY - 2004/6/16/pubmed PY - 2005/1/14/medline PY - 2004/6/16/entrez SP - 1133 EP - 8 JF - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons JO - Am. J. Transplant. VL - 4 IS - 7 N2 - Studies suggest donor age and year of transplantation are associated with low graft survival in liver transplant recipients with hepatitis C. We sought to determine if advanced donor age and recent year of transplantation are associated with graft survival in hepatitis C recipients and to determine if the effect of donor age on graft survival is specific to hepatitis C. We analyzed the United Network for Organ Sharing liver transplant database from 1994 to 2002. Six thousand four hundred and four subjects transplanted for end-stage liver disease from chronic hepatitis C met our criteria. One-year graft survival in hepatitis C recipients with organs from donors <40 years old and >or=60 years old was 84% and 73%, p = 0.003, respectively. These rates in recipients with cholestatic liver disease and alcoholic liver disease were 85% and 82%, respectively, p = 0.11 and 82% and 78%, respectively, p = 0.14. Three-year graft survival in hepatitis C recipients transplanted from 1994 to 1995 and 1996 to 1999 was 67% and 69%, respectively, p = 0.10. Graft survival in hepatitis C recipients has not declined in recent years. Older donor age is associated with lower short-term graft survival in recipients with hepatitis C, but not in recipients with cholestatic or alcoholic liver disease. SN - 1600-6135 UR - https://www.unboundmedicine.com/medline/citation/15196072/Impact_of_donor_age_and_year_of_transplant_on_graft_survival_in_liver_transplant_recipients_with_chronic_hepatitis_C_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=1600-6135&amp;date=2004&amp;volume=4&amp;issue=7&amp;spage=1133 DB - PRIME DP - Unbound Medicine ER -