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Presence of staphylococcal exfoliative toxin A in sera of patients with atopic dermatitis.
Clin Exp Allergy. 2004 Jun; 34(6):984-93.CE

Abstract

BACKGROUND

It has been reported that the toxins that Staphylococcus aureus produces are associated with the exacerbation of atopic dermatitis (AD). It has been shown in many studies that staphylococcal enterotoxin (SE) A and SEB contribute to AD by humoral immunity through IgE production as a superantigen. On the other hand, little attention has been paid to the relationship between AD and exfoliative toxin x (ETx).

OBJECTIVE

We investigated the toxins that are frequently detected from the skin of patients and how these toxins affect AD.

METHODS

S. aureus, isolated from the skin of 100 patients with mild to severe AD, were examined for the producibility of toxins by polymerase chain reaction. Serum samples were obtained from 21 patients with mild and moderate AD. The levels of SEB, ETA, total IgE, specific IgE, and specific IgG in sera were measured by ELISA.

RESULTS

SEB was most frequently detected from S. aureus on the skin of these patients as previously reported. And ETx, to which little attention has been paid so far, was frequently detected next to SEB. Furthermore, ETA was detected from the sera of almost all the AD patients. SEB was not detected at all. Although the level of ETA in the AD group was significantly higher than that of controls, ETA-specific IgE was not detected from their sera. High levels of ETA tended to be detected from infantile patients. Although there were no significant differences in the levels of ETA-IgG between AD and the controls, its prevalence was more than twice as high as the controls in AD.

CONCLUSION

These results suggest that many AD patients were exposed to ETx. We conclude that ETx may contribute to exacerbation of AD, particularly in infants, by a mechanism that is not through specific IgE production, unlike SEB.

Authors+Show Affiliations

Club Cosmetics Co., Ltd., Research and Development Division, Nara, Japan. syagi@clubcosmetics.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15196290

Citation

Yagi, S, et al. "Presence of Staphylococcal Exfoliative Toxin a in Sera of Patients With Atopic Dermatitis." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 34, no. 6, 2004, pp. 984-93.
Yagi S, Wakaki N, Ikeda N, et al. Presence of staphylococcal exfoliative toxin A in sera of patients with atopic dermatitis. Clin Exp Allergy. 2004;34(6):984-93.
Yagi, S., Wakaki, N., Ikeda, N., Takagi, Y., Uchida, H., Kato, Y., & Minamino, M. (2004). Presence of staphylococcal exfoliative toxin A in sera of patients with atopic dermatitis. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 34(6), 984-93.
Yagi S, et al. Presence of Staphylococcal Exfoliative Toxin a in Sera of Patients With Atopic Dermatitis. Clin Exp Allergy. 2004;34(6):984-93. PubMed PMID: 15196290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Presence of staphylococcal exfoliative toxin A in sera of patients with atopic dermatitis. AU - Yagi,S, AU - Wakaki,N, AU - Ikeda,N, AU - Takagi,Y, AU - Uchida,H, AU - Kato,Y, AU - Minamino,M, PY - 2004/6/16/pubmed PY - 2004/9/21/medline PY - 2004/6/16/entrez SP - 984 EP - 93 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 34 IS - 6 N2 - BACKGROUND: It has been reported that the toxins that Staphylococcus aureus produces are associated with the exacerbation of atopic dermatitis (AD). It has been shown in many studies that staphylococcal enterotoxin (SE) A and SEB contribute to AD by humoral immunity through IgE production as a superantigen. On the other hand, little attention has been paid to the relationship between AD and exfoliative toxin x (ETx). OBJECTIVE: We investigated the toxins that are frequently detected from the skin of patients and how these toxins affect AD. METHODS: S. aureus, isolated from the skin of 100 patients with mild to severe AD, were examined for the producibility of toxins by polymerase chain reaction. Serum samples were obtained from 21 patients with mild and moderate AD. The levels of SEB, ETA, total IgE, specific IgE, and specific IgG in sera were measured by ELISA. RESULTS: SEB was most frequently detected from S. aureus on the skin of these patients as previously reported. And ETx, to which little attention has been paid so far, was frequently detected next to SEB. Furthermore, ETA was detected from the sera of almost all the AD patients. SEB was not detected at all. Although the level of ETA in the AD group was significantly higher than that of controls, ETA-specific IgE was not detected from their sera. High levels of ETA tended to be detected from infantile patients. Although there were no significant differences in the levels of ETA-IgG between AD and the controls, its prevalence was more than twice as high as the controls in AD. CONCLUSION: These results suggest that many AD patients were exposed to ETx. We conclude that ETx may contribute to exacerbation of AD, particularly in infants, by a mechanism that is not through specific IgE production, unlike SEB. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/15196290/Presence_of_staphylococcal_exfoliative_toxin_A_in_sera_of_patients_with_atopic_dermatitis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=2004&volume=34&issue=6&spage=984 DB - PRIME DP - Unbound Medicine ER -