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Glutamic acid and histamine-sensitive neurons in the ventral hippocampus and the basolateral amygdala of the rat: functional interaction on memory and learning processes.
Behav Brain Res. 2004 Jul 09; 152(2):209-19.BB

Abstract

The possibility of a functional interaction between the amygdala and the ventral hippocampus during learning of a conditioned avoidance response when both brain structures are chemically stimulated with glutamic acid and/or histamine receptor antagonists (pyrilamine, H1-histamine antagonist and ranitidine, H2-histamine receptor antagonist) was studied in rats. Adult male rats were stereotaxically implanted with guide cannulae into the basolateral amygdala (A) and the ventral hippocampus (H). Seventy-two hours after the implant, rats were microinjected with 1 microl of saline solution, 10 nmol glutamic acid or 45 nmol of histamine receptor antagonists in several brain structures combinations. These combinations were: HsalAsal; HmsgAmsg; HmsgAsal; HsalAmsg; HpyrAmsg; HmsgApyr; HranAmsg and HmsgAran. Five minutes after the injection, rats were subjected to a learning task which consisted to avoid an electric shock applied to the animal's feet when an ultrasonic tone of 40 kHz is on for 30 s. Results showed that the simultaneous application of glutamic acid into hippocampus and amygdala interfered with the latency to escape and memory consolidation process. Stimulation with glutamic acid alone into the hippocampus or into the amygdala (HsalAmsg and HmsgAsal groups) interfered slightly with latency but impaired the consolidation process. Blocking the H1-histamine receptors of the amygdala affected slightly latency and efficiency of learning, meanwhile the blocking of H2-histamine receptors interfered with both parameters. Blocking H1- and H2-histamine receptors of the hippocampus significantly impaired latency and efficiency of learning of rats stimulated with glutamic acid into the amygdala. In conclusion, the experimental evidence suggests that hippocampal glutamic acid-neurons functionally interact with histamine-neurons in the basolateral amygdala to modulate memory and learning process.

Authors+Show Affiliations

Unidad de Neuroquímica y Farmacología del Comportamiento (UNEFCO), Instituto de Neurociencias y Humanidades Médicas, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, CC 33, Mendoza 5500, Argentina. ealvarez@fmed2.uncu.edu.arNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15196788

Citation

Alvarez, Edgardo O., and Marcela B. Ruarte. "Glutamic Acid and Histamine-sensitive Neurons in the Ventral Hippocampus and the Basolateral Amygdala of the Rat: Functional Interaction On Memory and Learning Processes." Behavioural Brain Research, vol. 152, no. 2, 2004, pp. 209-19.
Alvarez EO, Ruarte MB. Glutamic acid and histamine-sensitive neurons in the ventral hippocampus and the basolateral amygdala of the rat: functional interaction on memory and learning processes. Behav Brain Res. 2004;152(2):209-19.
Alvarez, E. O., & Ruarte, M. B. (2004). Glutamic acid and histamine-sensitive neurons in the ventral hippocampus and the basolateral amygdala of the rat: functional interaction on memory and learning processes. Behavioural Brain Research, 152(2), 209-19.
Alvarez EO, Ruarte MB. Glutamic Acid and Histamine-sensitive Neurons in the Ventral Hippocampus and the Basolateral Amygdala of the Rat: Functional Interaction On Memory and Learning Processes. Behav Brain Res. 2004 Jul 9;152(2):209-19. PubMed PMID: 15196788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glutamic acid and histamine-sensitive neurons in the ventral hippocampus and the basolateral amygdala of the rat: functional interaction on memory and learning processes. AU - Alvarez,Edgardo O, AU - Ruarte,Marcela B, PY - 2003/05/20/received PY - 2003/09/23/revised PY - 2003/10/04/accepted PY - 2004/6/16/pubmed PY - 2004/9/14/medline PY - 2004/6/16/entrez SP - 209 EP - 19 JF - Behavioural brain research JO - Behav Brain Res VL - 152 IS - 2 N2 - The possibility of a functional interaction between the amygdala and the ventral hippocampus during learning of a conditioned avoidance response when both brain structures are chemically stimulated with glutamic acid and/or histamine receptor antagonists (pyrilamine, H1-histamine antagonist and ranitidine, H2-histamine receptor antagonist) was studied in rats. Adult male rats were stereotaxically implanted with guide cannulae into the basolateral amygdala (A) and the ventral hippocampus (H). Seventy-two hours after the implant, rats were microinjected with 1 microl of saline solution, 10 nmol glutamic acid or 45 nmol of histamine receptor antagonists in several brain structures combinations. These combinations were: HsalAsal; HmsgAmsg; HmsgAsal; HsalAmsg; HpyrAmsg; HmsgApyr; HranAmsg and HmsgAran. Five minutes after the injection, rats were subjected to a learning task which consisted to avoid an electric shock applied to the animal's feet when an ultrasonic tone of 40 kHz is on for 30 s. Results showed that the simultaneous application of glutamic acid into hippocampus and amygdala interfered with the latency to escape and memory consolidation process. Stimulation with glutamic acid alone into the hippocampus or into the amygdala (HsalAmsg and HmsgAsal groups) interfered slightly with latency but impaired the consolidation process. Blocking the H1-histamine receptors of the amygdala affected slightly latency and efficiency of learning, meanwhile the blocking of H2-histamine receptors interfered with both parameters. Blocking H1- and H2-histamine receptors of the hippocampus significantly impaired latency and efficiency of learning of rats stimulated with glutamic acid into the amygdala. In conclusion, the experimental evidence suggests that hippocampal glutamic acid-neurons functionally interact with histamine-neurons in the basolateral amygdala to modulate memory and learning process. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/15196788/Glutamic_acid_and_histamine_sensitive_neurons_in_the_ventral_hippocampus_and_the_basolateral_amygdala_of_the_rat:_functional_interaction_on_memory_and_learning_processes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166432803003760 DB - PRIME DP - Unbound Medicine ER -