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Genetic variants in SOD2, MPO, and NQO1, and risk of ovarian cancer.
Gynecol Oncol. 2004 Jun; 93(3):615-20.GO

Abstract

OBJECTIVE

One way in which parity and use of oral contraceptives may protect against ovarian cancer is by preventing inflammation and oxidative stress associated with ovulation. Since the genes superoxide dismutase (SOD2), myeloperoxidase (MPO), and NAD(P)H:quinone oxidoreductase 1 (NQO1) are involved in inflammation and oxidative stress, we investigated whether variants of these genes are associated with risk of ovarian cancer.

METHODS

In a hospital-based case-control study, we compared 125 cases and 193 controls with respect to prevalence of (1) the T-->C (val-->ala) substitution at the -9 position in the signal sequence of SOD2; (2) the G-->A substitution at the -463 position in the promoter region of MPO; and (3) the C-->T (pro-->ser) change in exon 6 of NQO1. Genotyping was done using PCR and gel electrophoresis for MPO and NQO1 and using MALDI-TOF mass spectrometry for SOD2.

RESULTS

For SOD2, women with the TC (val/ala) or CC (ala/ala) genotypes were at increased risk [odds ratio (OR) 2.1, 95% confidence interval (CI) 1.1-4.0]. Results for MPO and NQO1 were in the hypothesized directions but were not statistically significant. For MPO, there was a small inverse association among women with GA or AA genotypes (OR = 0.72, 95% CI 0.43-1.2). For NQO1, the TT (ser/ser) genotype was associated with somewhat increased risk (OR = 2.3, 95% CI 0.69-7.6).

CONCLUSIONS

While these results need to be confirmed in other studies, they point to a possible role for genes involved in oxidative stress in the development of ovarian cancer.

Authors+Show Affiliations

Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. olsons@mskcc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15196853

Citation

Olson, S H., et al. "Genetic Variants in SOD2, MPO, and NQO1, and Risk of Ovarian Cancer." Gynecologic Oncology, vol. 93, no. 3, 2004, pp. 615-20.
Olson SH, Carlson MD, Ostrer H, et al. Genetic variants in SOD2, MPO, and NQO1, and risk of ovarian cancer. Gynecol Oncol. 2004;93(3):615-20.
Olson, S. H., Carlson, M. D., Ostrer, H., Harlap, S., Stone, A., Winters, M., & Ambrosone, C. B. (2004). Genetic variants in SOD2, MPO, and NQO1, and risk of ovarian cancer. Gynecologic Oncology, 93(3), 615-20.
Olson SH, et al. Genetic Variants in SOD2, MPO, and NQO1, and Risk of Ovarian Cancer. Gynecol Oncol. 2004;93(3):615-20. PubMed PMID: 15196853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic variants in SOD2, MPO, and NQO1, and risk of ovarian cancer. AU - Olson,S H, AU - Carlson,M D A, AU - Ostrer,H, AU - Harlap,S, AU - Stone,A, AU - Winters,M, AU - Ambrosone,C B, PY - 2003/09/12/received PY - 2004/6/16/pubmed PY - 2004/7/28/medline PY - 2004/6/16/entrez SP - 615 EP - 20 JF - Gynecologic oncology JO - Gynecol Oncol VL - 93 IS - 3 N2 - OBJECTIVE: One way in which parity and use of oral contraceptives may protect against ovarian cancer is by preventing inflammation and oxidative stress associated with ovulation. Since the genes superoxide dismutase (SOD2), myeloperoxidase (MPO), and NAD(P)H:quinone oxidoreductase 1 (NQO1) are involved in inflammation and oxidative stress, we investigated whether variants of these genes are associated with risk of ovarian cancer. METHODS: In a hospital-based case-control study, we compared 125 cases and 193 controls with respect to prevalence of (1) the T-->C (val-->ala) substitution at the -9 position in the signal sequence of SOD2; (2) the G-->A substitution at the -463 position in the promoter region of MPO; and (3) the C-->T (pro-->ser) change in exon 6 of NQO1. Genotyping was done using PCR and gel electrophoresis for MPO and NQO1 and using MALDI-TOF mass spectrometry for SOD2. RESULTS: For SOD2, women with the TC (val/ala) or CC (ala/ala) genotypes were at increased risk [odds ratio (OR) 2.1, 95% confidence interval (CI) 1.1-4.0]. Results for MPO and NQO1 were in the hypothesized directions but were not statistically significant. For MPO, there was a small inverse association among women with GA or AA genotypes (OR = 0.72, 95% CI 0.43-1.2). For NQO1, the TT (ser/ser) genotype was associated with somewhat increased risk (OR = 2.3, 95% CI 0.69-7.6). CONCLUSIONS: While these results need to be confirmed in other studies, they point to a possible role for genes involved in oxidative stress in the development of ovarian cancer. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/15196853/Genetic_variants_in_SOD2_MPO_and_NQO1_and_risk_of_ovarian_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S009082580400201X DB - PRIME DP - Unbound Medicine ER -