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Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy.

Abstract

OBJECTIVE

To examine the intake of antioxidant vitamins and carotenoids as well as fruits and vegetables in relation to the development of age-related maculopathy (ARM).

METHODS

We conducted a prospective follow-up study of women in the Nurses' Health Study and men in the Health Professionals Follow-up Study. We followed 77 562 women and 40 866 men who were at least 50 years of age and had no diagnosis of ARM or cancer at baseline for up to 18 years for women and up to 12 years for men. Fruit and vegetable intakes were assessed with a validated semiquantitative food-frequency questionnaire up to 5 times for women and up to 3 times for men during follow-up.

RESULTS

A total of 464 (329 women and 135 men) incident cases of early ARM and 316 (217 women and 99men) cases of neovascular ARM, all with visual loss of 20/30 or worse due primarily to ARM, were diagnosed during follow-up. Fruit intake was inversely associated with the risk of neovascular ARM. Participants who consumed 3 or more servings per day of fruits had a pooled multivariate relative risk of 0.64 (95% confidence interval, 0.44-0.93; P value for trend =.004) compared with those who consumed less than 1.5 servings per day. The results were similar in women and men. However, intakes of vegetables, antioxidant vitamins, or carotenoids were not strongly related to either early or neovascular ARM.

CONCLUSION

These data suggest a protective role for fruit intake on the risk of neovascular ARM.

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  • Authors+Show Affiliations

    ,

    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. eunyoung.cho@channing.harvard.edu

    , , ,

    Source

    MeSH

    Adult
    Aged
    Antioxidants
    Carotenoids
    Diet
    Diet Records
    Feeding Behavior
    Female
    Follow-Up Studies
    Fruit
    Humans
    Incidence
    Macular Degeneration
    Male
    Middle Aged
    Prospective Studies
    Risk Factors
    United States
    Vegetables
    Vitamins

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15197064

    Citation

    Cho, Eunyoung, et al. "Prospective Study of Intake of Fruits, Vegetables, Vitamins, and Carotenoids and Risk of Age-related Maculopathy." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 122, no. 6, 2004, pp. 883-92.
    Cho E, Seddon JM, Rosner B, et al. Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Arch Ophthalmol. 2004;122(6):883-92.
    Cho, E., Seddon, J. M., Rosner, B., Willett, W. C., & Hankinson, S. E. (2004). Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Archives of Ophthalmology (Chicago, Ill. : 1960), 122(6), pp. 883-92.
    Cho E, et al. Prospective Study of Intake of Fruits, Vegetables, Vitamins, and Carotenoids and Risk of Age-related Maculopathy. Arch Ophthalmol. 2004;122(6):883-92. PubMed PMID: 15197064.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. AU - Cho,Eunyoung, AU - Seddon,Johanna M, AU - Rosner,Bernard, AU - Willett,Walter C, AU - Hankinson,Susan E, PY - 2004/6/16/pubmed PY - 2004/7/21/medline PY - 2004/6/16/entrez SP - 883 EP - 92 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 122 IS - 6 N2 - OBJECTIVE: To examine the intake of antioxidant vitamins and carotenoids as well as fruits and vegetables in relation to the development of age-related maculopathy (ARM). METHODS: We conducted a prospective follow-up study of women in the Nurses' Health Study and men in the Health Professionals Follow-up Study. We followed 77 562 women and 40 866 men who were at least 50 years of age and had no diagnosis of ARM or cancer at baseline for up to 18 years for women and up to 12 years for men. Fruit and vegetable intakes were assessed with a validated semiquantitative food-frequency questionnaire up to 5 times for women and up to 3 times for men during follow-up. RESULTS: A total of 464 (329 women and 135 men) incident cases of early ARM and 316 (217 women and 99men) cases of neovascular ARM, all with visual loss of 20/30 or worse due primarily to ARM, were diagnosed during follow-up. Fruit intake was inversely associated with the risk of neovascular ARM. Participants who consumed 3 or more servings per day of fruits had a pooled multivariate relative risk of 0.64 (95% confidence interval, 0.44-0.93; P value for trend =.004) compared with those who consumed less than 1.5 servings per day. The results were similar in women and men. However, intakes of vegetables, antioxidant vitamins, or carotenoids were not strongly related to either early or neovascular ARM. CONCLUSION: These data suggest a protective role for fruit intake on the risk of neovascular ARM. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/15197064/full_citation L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/archopht.122.6.883 DB - PRIME DP - Unbound Medicine ER -