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Modafinil vs. caffeine: effects on fatigue during sleep deprivation.
Aviat Space Environ Med 2004; 75(6):520-5AS

Abstract

INTRODUCTION

The extent to which modafinil and caffeine reverse fatigue effects (defined as performance decrements with time on task) during total sleep deprivation was investigated.

METHODS

There were 50 healthy young adults who remained awake for 54.5 h (06:30 day 1 to 13:00 day 3). A 10-min vigilance test was administered bi-hourly from 08:00 day 1 until 22:00 day 2. At 23:55 day 2 (after 41.5 h awake), double-blind administration of one of five drug doses (placebo; modafinil 100, 200, or 400 mg; or caffeine 600 mg; n = 10 per group) was followed by hourly testing from 00:00 through 12:00 day 3. Response speed (reciprocal of reaction time) across the 10-min task (by 1-min block) was analyzed prior to and after drug administration.

RESULTS

A fatigue effect (response speed degradation across the 10-min task) was exacerbated by sleep deprivation and circadian rhythmicity. Prior to the drug, this effect was maximal between 08:00 and 12:00 day 3 (24-28 h sleep deprivation). Modafinil 400 mg attenuated fatigue in a manner comparable to that seen with caffeine 600 mg; these effects were especially salient during the circadian nadir of performance (06:00 through 10:00); modafinil 200 mg also reversed fatigue, but for a shorter duration (3 min) than modafinil 400 mg (8 min) or caffeine 600 mg (6 min).

DISCUSSION AND CONCLUSIONS

Time-on-task effects contributed to the performance degradation seen during sleep deprivation; effects which were reversed by caffeine and, at appropriate doses, by modafinil. Because the duration of efficacy for reversing time-on-task effects was shorter at lower drug dosages, the latter must be considered when determining the appropriate dose to use during sustained operations.

Authors+Show Affiliations

Department of Behavioral Biology, Division of Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910-7500, USA. nancy.wesensten@na.amedd.army.milNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15198278

Citation

Wesensten, Nancy Jo, et al. "Modafinil Vs. Caffeine: Effects On Fatigue During Sleep Deprivation." Aviation, Space, and Environmental Medicine, vol. 75, no. 6, 2004, pp. 520-5.
Wesensten NJ, Belenky G, Thorne DR, et al. Modafinil vs. caffeine: effects on fatigue during sleep deprivation. Aviat Space Environ Med. 2004;75(6):520-5.
Wesensten, N. J., Belenky, G., Thorne, D. R., Kautz, M. A., & Balkin, T. J. (2004). Modafinil vs. caffeine: effects on fatigue during sleep deprivation. Aviation, Space, and Environmental Medicine, 75(6), pp. 520-5.
Wesensten NJ, et al. Modafinil Vs. Caffeine: Effects On Fatigue During Sleep Deprivation. Aviat Space Environ Med. 2004;75(6):520-5. PubMed PMID: 15198278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modafinil vs. caffeine: effects on fatigue during sleep deprivation. AU - Wesensten,Nancy Jo, AU - Belenky,Gregory, AU - Thorne,David R, AU - Kautz,Mary A, AU - Balkin,Thomas J, PY - 2004/6/17/pubmed PY - 2004/8/27/medline PY - 2004/6/17/entrez SP - 520 EP - 5 JF - Aviation, space, and environmental medicine JO - Aviat Space Environ Med VL - 75 IS - 6 N2 - INTRODUCTION: The extent to which modafinil and caffeine reverse fatigue effects (defined as performance decrements with time on task) during total sleep deprivation was investigated. METHODS: There were 50 healthy young adults who remained awake for 54.5 h (06:30 day 1 to 13:00 day 3). A 10-min vigilance test was administered bi-hourly from 08:00 day 1 until 22:00 day 2. At 23:55 day 2 (after 41.5 h awake), double-blind administration of one of five drug doses (placebo; modafinil 100, 200, or 400 mg; or caffeine 600 mg; n = 10 per group) was followed by hourly testing from 00:00 through 12:00 day 3. Response speed (reciprocal of reaction time) across the 10-min task (by 1-min block) was analyzed prior to and after drug administration. RESULTS: A fatigue effect (response speed degradation across the 10-min task) was exacerbated by sleep deprivation and circadian rhythmicity. Prior to the drug, this effect was maximal between 08:00 and 12:00 day 3 (24-28 h sleep deprivation). Modafinil 400 mg attenuated fatigue in a manner comparable to that seen with caffeine 600 mg; these effects were especially salient during the circadian nadir of performance (06:00 through 10:00); modafinil 200 mg also reversed fatigue, but for a shorter duration (3 min) than modafinil 400 mg (8 min) or caffeine 600 mg (6 min). DISCUSSION AND CONCLUSIONS: Time-on-task effects contributed to the performance degradation seen during sleep deprivation; effects which were reversed by caffeine and, at appropriate doses, by modafinil. Because the duration of efficacy for reversing time-on-task effects was shorter at lower drug dosages, the latter must be considered when determining the appropriate dose to use during sustained operations. SN - 0095-6562 UR - https://www.unboundmedicine.com/medline/citation/15198278/Modafinil_vs__caffeine:_effects_on_fatigue_during_sleep_deprivation_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=0095-6562&volume=75&issue=6&spage=520&aulast=Wesensten DB - PRIME DP - Unbound Medicine ER -