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Midodrine prescribed to improve recurrent post-spaceflight orthostatic hypotension.
Aviat Space Environ Med. 2004 Jun; 75(6):554-6.AS

Abstract

Many astronauts exhibit post-spaceflight orthostatic hypotension due to inadequate norepinephrine release when in an upright posture. We hypothesized that an alpha1-adrenergic agonist, midodrine, would be an effective countermeasure. A female astronaut, who had problems with postflight orthostatic hypotension after a previous flight, consumed 10 mg midodrine after a subsequent flight, prior to her tilt test. Hemodynamic variables were compared between the two flights. Midodrine prevented severe falls in stroke volume, cardiac output and systolic pressure, and severe increases in heart rate without increasing vascular resistance, thus preventing orthostatic hypotension. This is the first report showing that midodrine has the potential to improve post-spaceflight orthostatic hypotension and suggesting that reduced venous return contributes to the etiology.

Authors+Show Affiliations

Universities Space Research Association, Houston, TX, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

15198285

Citation

Platts, Steven H., et al. "Midodrine Prescribed to Improve Recurrent Post-spaceflight Orthostatic Hypotension." Aviation, Space, and Environmental Medicine, vol. 75, no. 6, 2004, pp. 554-6.
Platts SH, Ziegler MG, Waters WW, et al. Midodrine prescribed to improve recurrent post-spaceflight orthostatic hypotension. Aviat Space Environ Med. 2004;75(6):554-6.
Platts, S. H., Ziegler, M. G., Waters, W. W., Mitchell, B. M., & Meck, J. V. (2004). Midodrine prescribed to improve recurrent post-spaceflight orthostatic hypotension. Aviation, Space, and Environmental Medicine, 75(6), 554-6.
Platts SH, et al. Midodrine Prescribed to Improve Recurrent Post-spaceflight Orthostatic Hypotension. Aviat Space Environ Med. 2004;75(6):554-6. PubMed PMID: 15198285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Midodrine prescribed to improve recurrent post-spaceflight orthostatic hypotension. AU - Platts,Steven H, AU - Ziegler,Michael G, AU - Waters,Wendy W, AU - Mitchell,Brett M, AU - Meck,Janice V, PY - 2004/6/17/pubmed PY - 2004/8/27/medline PY - 2004/6/17/entrez KW - NASA Center JSC KW - NASA Discipline Cardiopulmonary SP - 554 EP - 6 JF - Aviation, space, and environmental medicine JO - Aviat Space Environ Med VL - 75 IS - 6 N2 - Many astronauts exhibit post-spaceflight orthostatic hypotension due to inadequate norepinephrine release when in an upright posture. We hypothesized that an alpha1-adrenergic agonist, midodrine, would be an effective countermeasure. A female astronaut, who had problems with postflight orthostatic hypotension after a previous flight, consumed 10 mg midodrine after a subsequent flight, prior to her tilt test. Hemodynamic variables were compared between the two flights. Midodrine prevented severe falls in stroke volume, cardiac output and systolic pressure, and severe increases in heart rate without increasing vascular resistance, thus preventing orthostatic hypotension. This is the first report showing that midodrine has the potential to improve post-spaceflight orthostatic hypotension and suggesting that reduced venous return contributes to the etiology. SN - 0095-6562 UR - https://www.unboundmedicine.com/medline/citation/15198285/Midodrine_prescribed_to_improve_recurrent_post_spaceflight_orthostatic_hypotension_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=0095-6562&volume=75&issue=6&spage=554&aulast=Platts DB - PRIME DP - Unbound Medicine ER -