TY - JOUR T1 - The 3-D model: does time plasticity represent the influence of tableting speed? A1 - Picker,Katharina M, Y1 - 2003/12/16/ PY - 2004/6/17/pubmed PY - 2004/9/8/medline PY - 2004/6/17/entrez SP - E66 EP - E66 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 4 IS - 4 N2 - The objective of this study is to test the hypothesis that time plasticity (parameter d from 3-D modeling) is influenced by tableting speed. Tablets were produced at different maximum relative densities (rho(rel, max)) on an instrumented eccentric tableting machine and on a linear rotary tableting machine replicator. Some 3-D data plots were prepared using pressure, normalized time, and porosity according to Heckel. After fitting of a twisted plane, the resulting parameters were analyzed in a 3-D parameter plot. The materials used were dicalcium phosphate dihydrate (DCPD), spray-dried lactose, microcrystalline cellulose (MCC), hydroxypropyl methylcellulose (HPMC), kappa-carrageenan (CAR), and theophylline monohydrate (TheoM). The results show that tableting speed especially influences the parameter d (time plasticity) of the 3-D model for plastically and viscoelastically deforming materials such as MCC, HPMC, CAR, and TheoM. For more plastically deforming materials such as MCC, HPMC, and TheoM, a subtle influence on omega is also visible. The stages of higher densification are affected more than the stages of lower densification. Brittle materials such as DCPD exhibit no influence of tableting speed. The influence of speed on spray-dried lactose is minor. The results are valid for data obtained from an eccentric tableting machine and also for data from a linear rotary tableting machine replicator. Thus, the empirically derived parameter time plasticity d really represents the influence of time. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/15198561/The_3_D_model:_does_time_plasticity_represent_the_influence_of_tableting_speed DB - PRIME DP - Unbound Medicine ER -