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Enalapril treatment and hospitalization with atrial tachyarrhythmias in patients with left ventricular dysfunction.
Am Heart J. 2004 Jun; 147(6):1061-5.AH

Abstract

BACKGROUND

Experimental and clinical evidence suggests a preventive role for agiotensin-coverting enzyme (ACE) inhibitors on the development of atrial fibrillation. However, the effect of ACE inhibition on hospitalization with atrial tachyarrhythmias in patients with left ventricular (LV) dysfunction is not known. We sought to determine whether enalapril treatment reduced hospitalizations with atrial tachyarrhythmias in patients with LV dysfunction.

METHODS

We performed a retrospective analysis of the Studies of Left Ventricular Dysfunction (SOLVD) trial. Hospitalizations with atrial tachyarrhythmias were noted.

RESULTS

A total of 192 hospitalizations with atrial tachyarrhythmias occurred in 158 patients during a follow-up period of 34 months. The time to first hospitalization with atrial tachyarrhythmias or death was significantly lower in the enalapril group (P =.005). In a multivariate analysis adjusting for the presence of atrial fibrillation at study entry, enalapril treatment was associated with a reduction in the rate of hospitalization with atrial tachyarrhythmias or death (RR, 0.87; 95% CI, 0.79-0.96; P =.007). The incidence of hospitalization with atrial tachyarrhythmias was 7.9 hospitalizations per 1000 patient-years of follow-up in the enalapril group, compared with 12.4 per 1000 patient-years in the placebo group (RR, 0.64; 95% CI, 0.48-0.85; P =.002).

CONCLUSION

Enalapril is associated with a decreased incidence of hospitalization with atrial tachyarrhythmias in patients with LV dysfunction.

Authors+Show Affiliations

Tufts-New England Medical Center, Department of Medicine, Division of Cardiolgy, Boston, Mass, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15199356

Citation

Alsheikh-Ali, Alawi A., et al. "Enalapril Treatment and Hospitalization With Atrial Tachyarrhythmias in Patients With Left Ventricular Dysfunction." American Heart Journal, vol. 147, no. 6, 2004, pp. 1061-5.
Alsheikh-Ali AA, Wang PJ, Rand W, et al. Enalapril treatment and hospitalization with atrial tachyarrhythmias in patients with left ventricular dysfunction. Am Heart J. 2004;147(6):1061-5.
Alsheikh-Ali, A. A., Wang, P. J., Rand, W., Konstam, M. A., Homoud, M. K., Link, M. S., Estes, N. A., Salem, D. N., & Al-Ahmad, A. M. (2004). Enalapril treatment and hospitalization with atrial tachyarrhythmias in patients with left ventricular dysfunction. American Heart Journal, 147(6), 1061-5.
Alsheikh-Ali AA, et al. Enalapril Treatment and Hospitalization With Atrial Tachyarrhythmias in Patients With Left Ventricular Dysfunction. Am Heart J. 2004;147(6):1061-5. PubMed PMID: 15199356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enalapril treatment and hospitalization with atrial tachyarrhythmias in patients with left ventricular dysfunction. AU - Alsheikh-Ali,Alawi A, AU - Wang,Paul J, AU - Rand,William, AU - Konstam,Marvin A, AU - Homoud,Munther K, AU - Link,Mark S, AU - Estes,N A Mark,3rd AU - Salem,Deeb N, AU - Al-Ahmad,Amin M, PY - 2004/6/17/pubmed PY - 2004/9/24/medline PY - 2004/6/17/entrez SP - 1061 EP - 5 JF - American heart journal JO - Am Heart J VL - 147 IS - 6 N2 - BACKGROUND: Experimental and clinical evidence suggests a preventive role for agiotensin-coverting enzyme (ACE) inhibitors on the development of atrial fibrillation. However, the effect of ACE inhibition on hospitalization with atrial tachyarrhythmias in patients with left ventricular (LV) dysfunction is not known. We sought to determine whether enalapril treatment reduced hospitalizations with atrial tachyarrhythmias in patients with LV dysfunction. METHODS: We performed a retrospective analysis of the Studies of Left Ventricular Dysfunction (SOLVD) trial. Hospitalizations with atrial tachyarrhythmias were noted. RESULTS: A total of 192 hospitalizations with atrial tachyarrhythmias occurred in 158 patients during a follow-up period of 34 months. The time to first hospitalization with atrial tachyarrhythmias or death was significantly lower in the enalapril group (P =.005). In a multivariate analysis adjusting for the presence of atrial fibrillation at study entry, enalapril treatment was associated with a reduction in the rate of hospitalization with atrial tachyarrhythmias or death (RR, 0.87; 95% CI, 0.79-0.96; P =.007). The incidence of hospitalization with atrial tachyarrhythmias was 7.9 hospitalizations per 1000 patient-years of follow-up in the enalapril group, compared with 12.4 per 1000 patient-years in the placebo group (RR, 0.64; 95% CI, 0.48-0.85; P =.002). CONCLUSION: Enalapril is associated with a decreased incidence of hospitalization with atrial tachyarrhythmias in patients with LV dysfunction. SN - 1097-6744 UR - https://www.unboundmedicine.com/medline/citation/15199356/Enalapril_treatment_and_hospitalization_with_atrial_tachyarrhythmias_in_patients_with_left_ventricular_dysfunction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002870304000535 DB - PRIME DP - Unbound Medicine ER -