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Long-term compliance and changes in plasma lipids, plant sterols and carotenoids in children and parents with FH consuming plant sterol ester-enriched spread.
Eur J Clin Nutr. 2004 Dec; 58(12):1612-20.EJ

Abstract

OBJECTIVE

To study the compliance and changes in plasma lipids, plant sterols, fat-soluble vitamins and carotenoids in children and parents with familial hypercholesterolemia (FH) consuming a plant sterol ester-enriched (PSE) spread.

DESIGN

A 26-week open-label follow-up of children who had previously been studied in a controlled cross-over design. The parents were also included in the open-label arm of the study.

SETTING

Outpatient clinic for treatment of hyperlipidemia.

SUBJECTS

A total of 37 children (7-13 y) and 20 parents (32-51 y) diagnosed with 'definite' or 'possible' heterozygous FH. In all, 19 of the parents, but no children, used statins. All were patients at the Lipid Clinic, National Hospital in Oslo.

INTERVENTIONS

Subjects were recommended to eat 20 g/day of PSE spread as part of their lipid-lowering diet.

RESULTS

The mean intake of PSE spread was 13.7 and 16.5 g/days in the children and parents, respectively, corresponding to 1.2 and 1.5 g of plant sterols. Plasma total cholesterol decreased by 9.1% in both children (P<0.001) and parents (P=0.002). The corresponding decreases in LDL cholesterol were 11.4% (P<0.001) and 11.0% (P=0.012). Increases in serum lathosterol, campesterol and sitosterol, adjusted for total cholesterol, were observed in the children (31, 96, 48%, respectively, P<0.001) at the end of the controlled cross-over period. In the parents, serum campesterol and sitosterol, adjusted for total cholesterol, increased by 92 and 39%, respectively (P< 0.001). Lipid-adjusted serum alpha- and beta-carotene decreased by 17.4% (P=0.008) and 10.9% (P=0.018), respectively, in the children at the end of the controlled PSE period, but increased again during the follow-up. In the parents, serum alpha- and beta-carotene concentrations were unchanged, while serum lutein and lycopene decreased by 7.3% (P=0.037) and 14.6% (P=0.044), respectively.

CONCLUSIONS

Sustained efficacy of cholesterol reduction and long-term compliance of PSE intake were demonstrated in this study.

Authors+Show Affiliations

Lipid Clinic, National Hospital, Oslo, Norway. agotlia@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15199384

Citation

Amundsen, A L., et al. "Long-term Compliance and Changes in Plasma Lipids, Plant Sterols and Carotenoids in Children and Parents With FH Consuming Plant Sterol Ester-enriched Spread." European Journal of Clinical Nutrition, vol. 58, no. 12, 2004, pp. 1612-20.
Amundsen AL, Ntanios F, Put Nv, et al. Long-term compliance and changes in plasma lipids, plant sterols and carotenoids in children and parents with FH consuming plant sterol ester-enriched spread. Eur J Clin Nutr. 2004;58(12):1612-20.
Amundsen, A. L., Ntanios, F., Put, N. v., & Ose, L. (2004). Long-term compliance and changes in plasma lipids, plant sterols and carotenoids in children and parents with FH consuming plant sterol ester-enriched spread. European Journal of Clinical Nutrition, 58(12), 1612-20.
Amundsen AL, et al. Long-term Compliance and Changes in Plasma Lipids, Plant Sterols and Carotenoids in Children and Parents With FH Consuming Plant Sterol Ester-enriched Spread. Eur J Clin Nutr. 2004;58(12):1612-20. PubMed PMID: 15199384.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term compliance and changes in plasma lipids, plant sterols and carotenoids in children and parents with FH consuming plant sterol ester-enriched spread. AU - Amundsen,A L, AU - Ntanios,F, AU - Put,N van der, AU - Ose,L, PY - 2004/6/17/pubmed PY - 2005/3/11/medline PY - 2004/6/17/entrez SP - 1612 EP - 20 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 58 IS - 12 N2 - OBJECTIVE: To study the compliance and changes in plasma lipids, plant sterols, fat-soluble vitamins and carotenoids in children and parents with familial hypercholesterolemia (FH) consuming a plant sterol ester-enriched (PSE) spread. DESIGN: A 26-week open-label follow-up of children who had previously been studied in a controlled cross-over design. The parents were also included in the open-label arm of the study. SETTING: Outpatient clinic for treatment of hyperlipidemia. SUBJECTS: A total of 37 children (7-13 y) and 20 parents (32-51 y) diagnosed with 'definite' or 'possible' heterozygous FH. In all, 19 of the parents, but no children, used statins. All were patients at the Lipid Clinic, National Hospital in Oslo. INTERVENTIONS: Subjects were recommended to eat 20 g/day of PSE spread as part of their lipid-lowering diet. RESULTS: The mean intake of PSE spread was 13.7 and 16.5 g/days in the children and parents, respectively, corresponding to 1.2 and 1.5 g of plant sterols. Plasma total cholesterol decreased by 9.1% in both children (P<0.001) and parents (P=0.002). The corresponding decreases in LDL cholesterol were 11.4% (P<0.001) and 11.0% (P=0.012). Increases in serum lathosterol, campesterol and sitosterol, adjusted for total cholesterol, were observed in the children (31, 96, 48%, respectively, P<0.001) at the end of the controlled cross-over period. In the parents, serum campesterol and sitosterol, adjusted for total cholesterol, increased by 92 and 39%, respectively (P< 0.001). Lipid-adjusted serum alpha- and beta-carotene decreased by 17.4% (P=0.008) and 10.9% (P=0.018), respectively, in the children at the end of the controlled PSE period, but increased again during the follow-up. In the parents, serum alpha- and beta-carotene concentrations were unchanged, while serum lutein and lycopene decreased by 7.3% (P=0.037) and 14.6% (P=0.044), respectively. CONCLUSIONS: Sustained efficacy of cholesterol reduction and long-term compliance of PSE intake were demonstrated in this study. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/15199384/Long_term_compliance_and_changes_in_plasma_lipids_plant_sterols_and_carotenoids_in_children_and_parents_with_FH_consuming_plant_sterol_ester_enriched_spread_ L2 - https://doi.org/10.1038/sj.ejcn.1602015 DB - PRIME DP - Unbound Medicine ER -