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Uterine receptivity and implantation: the regulation and action of insulin-like growth factor binding protein-1 (IGFBP-1), HOXA10 and forkhead transcription factor-1 (FOXO-1) in the baboon endometrium.
Reprod Biol Endocrinol. 2004 Jun 16; 2:34.RB

Abstract

In primates, the phase of the menstrual cycle when the uterus becomes receptive is initially dependent on estrogen and progesterone. Further morphological and biochemical changes are induced as a result of biochemical signals between the embryo and the maternal endometrium. Blastocyst implantation in the baboon usually occurs between 8 and 10 days post ovulation and is similar to that described for the rhesus macaque. In the baboon, when chorionic gonadotropin is infused in a manner that mimics blastocyst transit, this has physiological effects on the three major cell types in the uterine endometrium. The luminal epithelium undergoes endoreplication and distinct epithelial plaques are evident. The glandular epithelium responds by inducing transcriptional and post-translational modifications in the major secretory product, glycodelin. The stromal fibroblasts initiate their differentiation process into a decidual phenotype and are characterized by the expression of actin filaments. Decidualization, is the major change that occurs in the primate endometrium after conception. During this process the fibroblast-like stromal cells change morphologically into polygonal cells and express specific decidual proteins. Studies in the baboon demonstrated that insulin-like growth factor binding protein-1 (IGFBP-1) gene expression is a conceptus-mediated response. Subsequent studies in vitro established that IGFBP-1 is transcriptionally regulated by FOXO1 and HOXA10 which together upregulate the IGFBP-1 promoter activity. A baboon endometriosis model was utilized to determine if the changes observed during uterine receptivity in normally cycling animals were compromised. The data suggests that in animals with disease, markers of uterine receptivity are not appropriately expressed in the eutopic endometrium. It is possible that these differences influence the fertility of the animals with disease and the baboon could be used as a primate model to study the causes of infertility as a result of endometriosis.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL, USA. j-kim4@northwestern.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15200677

Citation

Kim, J J., and Asgerally T. Fazleabas. "Uterine Receptivity and Implantation: the Regulation and Action of Insulin-like Growth Factor Binding Protein-1 (IGFBP-1), HOXA10 and Forkhead Transcription Factor-1 (FOXO-1) in the Baboon Endometrium." Reproductive Biology and Endocrinology : RB&E, vol. 2, 2004, p. 34.
Kim JJ, Fazleabas AT. Uterine receptivity and implantation: the regulation and action of insulin-like growth factor binding protein-1 (IGFBP-1), HOXA10 and forkhead transcription factor-1 (FOXO-1) in the baboon endometrium. Reprod Biol Endocrinol. 2004;2:34.
Kim, J. J., & Fazleabas, A. T. (2004). Uterine receptivity and implantation: the regulation and action of insulin-like growth factor binding protein-1 (IGFBP-1), HOXA10 and forkhead transcription factor-1 (FOXO-1) in the baboon endometrium. Reproductive Biology and Endocrinology : RB&E, 2, 34.
Kim JJ, Fazleabas AT. Uterine Receptivity and Implantation: the Regulation and Action of Insulin-like Growth Factor Binding Protein-1 (IGFBP-1), HOXA10 and Forkhead Transcription Factor-1 (FOXO-1) in the Baboon Endometrium. Reprod Biol Endocrinol. 2004 Jun 16;2:34. PubMed PMID: 15200677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uterine receptivity and implantation: the regulation and action of insulin-like growth factor binding protein-1 (IGFBP-1), HOXA10 and forkhead transcription factor-1 (FOXO-1) in the baboon endometrium. AU - Kim,J J, AU - Fazleabas,Asgerally T, Y1 - 2004/06/16/ PY - 2004/03/01/received PY - 2004/06/16/accepted PY - 2004/6/18/pubmed PY - 2004/11/13/medline PY - 2004/6/18/entrez SP - 34 EP - 34 JF - Reproductive biology and endocrinology : RB&E JO - Reprod. Biol. Endocrinol. VL - 2 N2 - In primates, the phase of the menstrual cycle when the uterus becomes receptive is initially dependent on estrogen and progesterone. Further morphological and biochemical changes are induced as a result of biochemical signals between the embryo and the maternal endometrium. Blastocyst implantation in the baboon usually occurs between 8 and 10 days post ovulation and is similar to that described for the rhesus macaque. In the baboon, when chorionic gonadotropin is infused in a manner that mimics blastocyst transit, this has physiological effects on the three major cell types in the uterine endometrium. The luminal epithelium undergoes endoreplication and distinct epithelial plaques are evident. The glandular epithelium responds by inducing transcriptional and post-translational modifications in the major secretory product, glycodelin. The stromal fibroblasts initiate their differentiation process into a decidual phenotype and are characterized by the expression of actin filaments. Decidualization, is the major change that occurs in the primate endometrium after conception. During this process the fibroblast-like stromal cells change morphologically into polygonal cells and express specific decidual proteins. Studies in the baboon demonstrated that insulin-like growth factor binding protein-1 (IGFBP-1) gene expression is a conceptus-mediated response. Subsequent studies in vitro established that IGFBP-1 is transcriptionally regulated by FOXO1 and HOXA10 which together upregulate the IGFBP-1 promoter activity. A baboon endometriosis model was utilized to determine if the changes observed during uterine receptivity in normally cycling animals were compromised. The data suggests that in animals with disease, markers of uterine receptivity are not appropriately expressed in the eutopic endometrium. It is possible that these differences influence the fertility of the animals with disease and the baboon could be used as a primate model to study the causes of infertility as a result of endometriosis. SN - 1477-7827 UR - https://www.unboundmedicine.com/medline/citation/15200677/Uterine_receptivity_and_implantation:_the_regulation_and_action_of_insulin_like_growth_factor_binding_protein_1__IGFBP_1__HOXA10_and_forkhead_transcription_factor_1__FOXO_1__in_the_baboon_endometrium_ L2 - https://rbej.biomedcentral.com/articles/10.1186/1477-7827-2-34 DB - PRIME DP - Unbound Medicine ER -