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Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients.
Emerg Infect Dis. 2004 May; 10(5):818-24.EI

Abstract

Clinical and laboratory data on severe acute respiratory syndrome (SARS), particularly on the temporal progression of abnormal laboratory findings, are limited. We conducted a prospective study on the clinical, radiologic, and hematologic findings of SARS patients with pneumonia, who were admitted to National Taiwan University Hospital from March 8 to June 15, 2003. Fever was the most frequent initial symptom, followed by cough, myalgia, dyspnea, and diarrhea. Twenty-four patients had various underlying diseases. Most patients had elevated C-reactive protein (CRP) levels and lymphopenia. Other common abnormal laboratory findings included leukopenia, thrombocytopenia, and elevated levels of aminotransferase, lactate dehydrogenase, and creatine kinase. These clinical and laboratory findings were exacerbated in most patients during the second week of disease. The overall case-fatality rate was 19.7%. By multivariate analysis, underlying disease and initial CRP level were predictive of death.

Authors+Show Affiliations

National Taiwan University Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15200814

Citation

Wang, Jann-Tay, et al. "Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients." Emerging Infectious Diseases, vol. 10, no. 5, 2004, pp. 818-24.
Wang JT, Sheng WH, Fang CT, et al. Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients. Emerg Infect Dis. 2004;10(5):818-24.
Wang, J. T., Sheng, W. H., Fang, C. T., Chen, Y. C., Wang, J. L., Yu, C. J., Chang, S. C., & Yang, P. C. (2004). Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients. Emerging Infectious Diseases, 10(5), 818-24.
Wang JT, et al. Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients. Emerg Infect Dis. 2004;10(5):818-24. PubMed PMID: 15200814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients. AU - Wang,Jann-Tay, AU - Sheng,Wang-Huei, AU - Fang,Chi-Tai, AU - Chen,Yee-Chun, AU - Wang,Jiun-Ling, AU - Yu,Chong-Jen, AU - Chang,Shan-Chwen, AU - Yang,Pan-Chyr, PY - 2004/6/18/pubmed PY - 2004/8/21/medline PY - 2004/6/18/entrez SP - 818 EP - 24 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 10 IS - 5 N2 - Clinical and laboratory data on severe acute respiratory syndrome (SARS), particularly on the temporal progression of abnormal laboratory findings, are limited. We conducted a prospective study on the clinical, radiologic, and hematologic findings of SARS patients with pneumonia, who were admitted to National Taiwan University Hospital from March 8 to June 15, 2003. Fever was the most frequent initial symptom, followed by cough, myalgia, dyspnea, and diarrhea. Twenty-four patients had various underlying diseases. Most patients had elevated C-reactive protein (CRP) levels and lymphopenia. Other common abnormal laboratory findings included leukopenia, thrombocytopenia, and elevated levels of aminotransferase, lactate dehydrogenase, and creatine kinase. These clinical and laboratory findings were exacerbated in most patients during the second week of disease. The overall case-fatality rate was 19.7%. By multivariate analysis, underlying disease and initial CRP level were predictive of death. SN - 1080-6040 UR - https://www.unboundmedicine.com/medline/citation/15200814/Clinical_manifestations_laboratory_findings_and_treatment_outcomes_of_SARS_patients_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/15200814/ DB - PRIME DP - Unbound Medicine ER -