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Prospective and longitudinal patient self-assessment of health-related quality of life following radical perineal prostatectomy.
J Urol. 2004 Jul; 172(1):264-8.JU

Abstract

PURPOSE

We provide a comprehensive, longitudinal assessment of health related quality of life (HRQOL) following radical perineal prostatectomy (RPP).

MATERIALS AND METHODS

We report the results of a prospective cohort study of 109 patients with at least 3 months of followup who underwent RPP between January 2001 and July 2003. A validated patient self-assessment questionnaire, the Expanded Prostate Cancer Index Composite, was administered preoperatively, and 1, 3, 6, 9, 12 and 18 months postoperatively. Mean domain specific HRQOL scores were calculated as well as the proportion of patients achieving an individual baseline by each interval. The Cox proportional hazards model was used to identify predictors of a successful return to baseline of disease specific HRQOL scores.

RESULTS

HRQOL scores were lowest 1 month postoperatively and they increased with time. By 6 months a majority of patients had recovered baseline summary scores in urinary (65.1%), bowel (93.6%) and hormonal (91.7%) domains at a median of 5.8 (95% CI 3.6 to 6.2), 1.3 (95% CI 1.1 to 1.5) and 1.3 (95% CI 1.2 to 1.8) months, respectively. One in 4 patients recovered the sexual summary score by 18 months. Significant independent predictors for the recovery of domain summary scores were younger age in urinary (p = 0.001), individual surgeon in bowel (p = 0.022), and older age (p = 0.017) and absent medical comorbidities (p = 0.012) in hormonal domains.

CONCLUSIONS

A majority of patients undergoing RRP experience an early recovery of individual urinary, bowel and hormonal HRQOL. Future studies should establish the benefit of bilateral nerve sparing RPP on the recovery of sexual domain HRQOL.

Authors+Show Affiliations

Division of Urology, Department of Surgery and Cancer Center Biostatistics, Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina 27710, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15201791

Citation

Yang, Benjamin K., et al. "Prospective and Longitudinal Patient Self-assessment of Health-related Quality of Life Following Radical Perineal Prostatectomy." The Journal of Urology, vol. 172, no. 1, 2004, pp. 264-8.
Yang BK, Young MD, Calingaert B, et al. Prospective and longitudinal patient self-assessment of health-related quality of life following radical perineal prostatectomy. J Urol. 2004;172(1):264-8.
Yang, B. K., Young, M. D., Calingaert, B., Albala, D. M., Vieweg, J., Murphy, B. C., & Dahm, P. (2004). Prospective and longitudinal patient self-assessment of health-related quality of life following radical perineal prostatectomy. The Journal of Urology, 172(1), 264-8.
Yang BK, et al. Prospective and Longitudinal Patient Self-assessment of Health-related Quality of Life Following Radical Perineal Prostatectomy. J Urol. 2004;172(1):264-8. PubMed PMID: 15201791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective and longitudinal patient self-assessment of health-related quality of life following radical perineal prostatectomy. AU - Yang,Benjamin K, AU - Young,Matthew D, AU - Calingaert,Brian, AU - Albala,David M, AU - Vieweg,Johannes, AU - Murphy,Brian C, AU - Dahm,Philipp, PY - 2004/6/18/pubmed PY - 2004/8/3/medline PY - 2004/6/18/entrez SP - 264 EP - 8 JF - The Journal of urology JO - J Urol VL - 172 IS - 1 N2 - PURPOSE: We provide a comprehensive, longitudinal assessment of health related quality of life (HRQOL) following radical perineal prostatectomy (RPP). MATERIALS AND METHODS: We report the results of a prospective cohort study of 109 patients with at least 3 months of followup who underwent RPP between January 2001 and July 2003. A validated patient self-assessment questionnaire, the Expanded Prostate Cancer Index Composite, was administered preoperatively, and 1, 3, 6, 9, 12 and 18 months postoperatively. Mean domain specific HRQOL scores were calculated as well as the proportion of patients achieving an individual baseline by each interval. The Cox proportional hazards model was used to identify predictors of a successful return to baseline of disease specific HRQOL scores. RESULTS: HRQOL scores were lowest 1 month postoperatively and they increased with time. By 6 months a majority of patients had recovered baseline summary scores in urinary (65.1%), bowel (93.6%) and hormonal (91.7%) domains at a median of 5.8 (95% CI 3.6 to 6.2), 1.3 (95% CI 1.1 to 1.5) and 1.3 (95% CI 1.2 to 1.8) months, respectively. One in 4 patients recovered the sexual summary score by 18 months. Significant independent predictors for the recovery of domain summary scores were younger age in urinary (p = 0.001), individual surgeon in bowel (p = 0.022), and older age (p = 0.017) and absent medical comorbidities (p = 0.012) in hormonal domains. CONCLUSIONS: A majority of patients undergoing RRP experience an early recovery of individual urinary, bowel and hormonal HRQOL. Future studies should establish the benefit of bilateral nerve sparing RPP on the recovery of sexual domain HRQOL. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/15201791/Prospective_and_longitudinal_patient_self_assessment_of_health_related_quality_of_life_following_radical_perineal_prostatectomy_ L2 - https://www.jurology.com/doi/10.1097/01.ju.0000128775.27331.d7?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -