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Peripartum serum vitamin E, retinol, and beta-carotene in dairy cattle and their associations with disease.
J Dairy Sci. 2004 Mar; 87(3):609-19.JD

Abstract

Peripartum decreases in serum concentrations of vitamins A and E may contribute to impaired immune function in dairy cows. The objectives of this study were to describe peripartum serum concentrations of alpha-tocopherol, beta-carotene, and retinol and their associations with disease risk. On 20 farms over 1 yr, blood samples were collected weekly from 1057 cows from 1 wk before expected calving until 1 wk postpartum. Serum concentrations of alpha-tocopherol, beta-carotene, and retinol, as well as several biochemical variables were measured. Their associations with the risk of retained placenta or clinical mastitis were modeled separately with logistic regression, and the factors associated with the concentration of each vitamin were modelled with mixed linear regression. Differences in vitamin concentrations between 2 batches of sera analyzed 6 mo apart required stratification of statistical analyses. Accounting for the effects of parity, season, and twins, an increase in alpha-tocopherol of 1 microg/mL in the last week prepartum reduced the risk of retained placenta by 20%, whereas serum nonesterified fatty acid concentration > or = 0.5 mEq/L tended to increase risk of retained placenta by 80%. In the last week prepartum, a 100 ng/mL increase in serum retinol was associated with a 60% decrease in the risk of early lactation clinical mastitis. There were significant positive associations of peripartum serum concentrations among each of alpha-tocopherol, beta-carotene, and retinol.

Authors+Show Affiliations

Department of Population Medicine, University of Guelph, Ontario, Canada N1G 2W1. sleblanc@ovc.uoguelph.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15202645

Citation

LeBlanc, S J., et al. "Peripartum Serum Vitamin E, Retinol, and Beta-carotene in Dairy Cattle and Their Associations With Disease." Journal of Dairy Science, vol. 87, no. 3, 2004, pp. 609-19.
LeBlanc SJ, Herdt TH, Seymour WM, et al. Peripartum serum vitamin E, retinol, and beta-carotene in dairy cattle and their associations with disease. J Dairy Sci. 2004;87(3):609-19.
LeBlanc, S. J., Herdt, T. H., Seymour, W. M., Duffield, T. F., & Leslie, K. E. (2004). Peripartum serum vitamin E, retinol, and beta-carotene in dairy cattle and their associations with disease. Journal of Dairy Science, 87(3), 609-19.
LeBlanc SJ, et al. Peripartum Serum Vitamin E, Retinol, and Beta-carotene in Dairy Cattle and Their Associations With Disease. J Dairy Sci. 2004;87(3):609-19. PubMed PMID: 15202645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripartum serum vitamin E, retinol, and beta-carotene in dairy cattle and their associations with disease. AU - LeBlanc,S J, AU - Herdt,T H, AU - Seymour,W M, AU - Duffield,T F, AU - Leslie,K E, PY - 2004/6/19/pubmed PY - 2004/7/23/medline PY - 2004/6/19/entrez SP - 609 EP - 19 JF - Journal of dairy science JO - J Dairy Sci VL - 87 IS - 3 N2 - Peripartum decreases in serum concentrations of vitamins A and E may contribute to impaired immune function in dairy cows. The objectives of this study were to describe peripartum serum concentrations of alpha-tocopherol, beta-carotene, and retinol and their associations with disease risk. On 20 farms over 1 yr, blood samples were collected weekly from 1057 cows from 1 wk before expected calving until 1 wk postpartum. Serum concentrations of alpha-tocopherol, beta-carotene, and retinol, as well as several biochemical variables were measured. Their associations with the risk of retained placenta or clinical mastitis were modeled separately with logistic regression, and the factors associated with the concentration of each vitamin were modelled with mixed linear regression. Differences in vitamin concentrations between 2 batches of sera analyzed 6 mo apart required stratification of statistical analyses. Accounting for the effects of parity, season, and twins, an increase in alpha-tocopherol of 1 microg/mL in the last week prepartum reduced the risk of retained placenta by 20%, whereas serum nonesterified fatty acid concentration > or = 0.5 mEq/L tended to increase risk of retained placenta by 80%. In the last week prepartum, a 100 ng/mL increase in serum retinol was associated with a 60% decrease in the risk of early lactation clinical mastitis. There were significant positive associations of peripartum serum concentrations among each of alpha-tocopherol, beta-carotene, and retinol. SN - 0022-0302 UR - https://www.unboundmedicine.com/medline/citation/15202645/Peripartum_serum_vitamin_E_retinol_and_beta_carotene_in_dairy_cattle_and_their_associations_with_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-0302(04)73203-8 DB - PRIME DP - Unbound Medicine ER -