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Long-lasting increase in corticospinal excitability after 1800 pulses of subthreshold 5 Hz repetitive TMS to the primary motor cortex.
Clin Neurophysiol. 2004 Jul; 115(7):1519-26.CN

Abstract

OBJECTIVE

To study the after effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) on corticospinal excitability.

METHODS

Eight healthy volunteers received either 150 or 1800 stimuli of 5 Hz rTMS on two separate days in a counterbalanced order. rTMS was given over the 'motor hot spot' of the right first dorsal interosseus (FDI) muscle using an intensity of 90% of resting motor threshold (referred to as subthreshold rTMS). We evaluated the amplitude of the motor-evoked potential (MEP), short-latency intracortical inhibition (SICI), short-latency intracortical facilitation (SICF), and cortical silent period (CSP) before and for about 30 min after rTMS. MEPs were recorded from the right FDI muscle and abductor digiti minimi (ADM) muscle.

RESULTS

1800 stimuli induced an increase in MEP amplitude in the relaxed FDI muscle, but not in the relaxed ADM muscle. This facilitatory after effect was stable for at least 30 min. Prolonged 5 Hz rTMS had no effect on the relative magnitude of SICI and SICF. 150 stimuli caused no lasting modulation of MEP amplitudes in either muscle. In a subgroup of 5 subjects, 900 conditioning stimuli caused only a short-lived MEP facilitation. 5 Hz rTMS did not modify the duration of the CSP during tonic contraction.

CONCLUSIONS

A single session of subthreshold 5 Hz rTMS to the M1 can induce a long-lasting and muscle-specific increase in resting corticospinal excitability. However, a sufficient number of conditioning stimuli is necessary to produce persistent corticospinal facilitation.

Authors+Show Affiliations

Department of Neurology, Technische Universität München, Möhlstrasse 28, D-81675 Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15203053

Citation

Peinemann, Alexander, et al. "Long-lasting Increase in Corticospinal Excitability After 1800 Pulses of Subthreshold 5 Hz Repetitive TMS to the Primary Motor Cortex." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 115, no. 7, 2004, pp. 1519-26.
Peinemann A, Reimer B, Löer C, et al. Long-lasting increase in corticospinal excitability after 1800 pulses of subthreshold 5 Hz repetitive TMS to the primary motor cortex. Clin Neurophysiol. 2004;115(7):1519-26.
Peinemann, A., Reimer, B., Löer, C., Quartarone, A., Münchau, A., Conrad, B., & Siebner, H. R. (2004). Long-lasting increase in corticospinal excitability after 1800 pulses of subthreshold 5 Hz repetitive TMS to the primary motor cortex. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 115(7), 1519-26.
Peinemann A, et al. Long-lasting Increase in Corticospinal Excitability After 1800 Pulses of Subthreshold 5 Hz Repetitive TMS to the Primary Motor Cortex. Clin Neurophysiol. 2004;115(7):1519-26. PubMed PMID: 15203053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-lasting increase in corticospinal excitability after 1800 pulses of subthreshold 5 Hz repetitive TMS to the primary motor cortex. AU - Peinemann,Alexander, AU - Reimer,Bibiana, AU - Löer,Christian, AU - Quartarone,Angelo, AU - Münchau,Alexander, AU - Conrad,Bastian, AU - Siebner,Hartwig Roman, PY - 2004/02/03/accepted PY - 2004/6/19/pubmed PY - 2004/8/18/medline PY - 2004/6/19/entrez SP - 1519 EP - 26 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 115 IS - 7 N2 - OBJECTIVE: To study the after effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) on corticospinal excitability. METHODS: Eight healthy volunteers received either 150 or 1800 stimuli of 5 Hz rTMS on two separate days in a counterbalanced order. rTMS was given over the 'motor hot spot' of the right first dorsal interosseus (FDI) muscle using an intensity of 90% of resting motor threshold (referred to as subthreshold rTMS). We evaluated the amplitude of the motor-evoked potential (MEP), short-latency intracortical inhibition (SICI), short-latency intracortical facilitation (SICF), and cortical silent period (CSP) before and for about 30 min after rTMS. MEPs were recorded from the right FDI muscle and abductor digiti minimi (ADM) muscle. RESULTS: 1800 stimuli induced an increase in MEP amplitude in the relaxed FDI muscle, but not in the relaxed ADM muscle. This facilitatory after effect was stable for at least 30 min. Prolonged 5 Hz rTMS had no effect on the relative magnitude of SICI and SICF. 150 stimuli caused no lasting modulation of MEP amplitudes in either muscle. In a subgroup of 5 subjects, 900 conditioning stimuli caused only a short-lived MEP facilitation. 5 Hz rTMS did not modify the duration of the CSP during tonic contraction. CONCLUSIONS: A single session of subthreshold 5 Hz rTMS to the M1 can induce a long-lasting and muscle-specific increase in resting corticospinal excitability. However, a sufficient number of conditioning stimuli is necessary to produce persistent corticospinal facilitation. SN - 1388-2457 UR - https://www.unboundmedicine.com/medline/citation/15203053/Long_lasting_increase_in_corticospinal_excitability_after_1800_pulses_of_subthreshold_5_Hz_repetitive_TMS_to_the_primary_motor_cortex_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388245704000598 DB - PRIME DP - Unbound Medicine ER -