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Circulating oxidized low-density lipoprotein and its association with carotid intima-media thickness in asymptomatic members of familial combined hyperlipidemia families.
Arterioscler Thromb Vasc Biol 2004; 24(8):1492-7AT

Abstract

OBJECTIVE

Oxidized low-density lipoprotein (Ox-LDL)is implicated in the pathogenesis of atherosclerosis. Circulating oxidation-specific epitopes on plasma Ox-LDL has been linked with coronary artery disease, but its determinants and its association with early development of atherosclerosis in familial combined hyperlipidemia (FCHL) has not been very well studied. This study aimed to investigate the determinants of the circulating Ox-LDL and the association between Ox-LDL and carotid intima-media thickness (IMT) in asymptomatic members of FCHL families.

METHODS AND RESULTS

Ox-LDL, susceptibility of LDL to oxidation in vitro, plasma 8-isoprostane and antioxidants, lipids and lipoproteins, LDL particle size, and carotid IMT were measured in 150 asymptomatic FCHL family members. Affected FCHL family members had reduced LDL particle size and lag time for LDL oxidation, increased plasma levels of Ox-LDL, increased plasma urate and alpha-tocopherol, and a trend for the increase of 8-isoprostane as compared with nonaffected FCHL. Ox-LDL was independently associated with serum LDL cholesterol, apoB, and 8-isoprostane in multivariate analysis but only univariately correlated with LDL particle size and lag time for LDL oxidation. In addition, Ox-LDL was significantly associated with carotid mean IMT independently of other clinical and biochemical variables in a multivariate model.

CONCLUSIONS

Serum LDL cholesterol, apoB levels, and 8-isoprostane were the most important determinants of Ox-LDL. Ox-LDL is independently associated with carotid IMT in asymptomatic FCHL family members and can be used as a marker of early atherosclerosis in FCHL.

Authors+Show Affiliations

Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15205217

Citation

Liu, Ming-Lin, et al. "Circulating Oxidized Low-density Lipoprotein and Its Association With Carotid Intima-media Thickness in Asymptomatic Members of Familial Combined Hyperlipidemia Families." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 8, 2004, pp. 1492-7.
Liu ML, Ylitalo K, Salonen R, et al. Circulating oxidized low-density lipoprotein and its association with carotid intima-media thickness in asymptomatic members of familial combined hyperlipidemia families. Arterioscler Thromb Vasc Biol. 2004;24(8):1492-7.
Liu, M. L., Ylitalo, K., Salonen, R., Salonen, J. T., & Taskinen, M. R. (2004). Circulating oxidized low-density lipoprotein and its association with carotid intima-media thickness in asymptomatic members of familial combined hyperlipidemia families. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(8), pp. 1492-7.
Liu ML, et al. Circulating Oxidized Low-density Lipoprotein and Its Association With Carotid Intima-media Thickness in Asymptomatic Members of Familial Combined Hyperlipidemia Families. Arterioscler Thromb Vasc Biol. 2004;24(8):1492-7. PubMed PMID: 15205217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating oxidized low-density lipoprotein and its association with carotid intima-media thickness in asymptomatic members of familial combined hyperlipidemia families. AU - Liu,Ming-Lin, AU - Ylitalo,Kati, AU - Salonen,Riitta, AU - Salonen,Jukka T, AU - Taskinen,Marja-Riitta, Y1 - 2004/06/17/ PY - 2004/6/19/pubmed PY - 2005/2/11/medline PY - 2004/6/19/entrez SP - 1492 EP - 7 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 24 IS - 8 N2 - OBJECTIVE: Oxidized low-density lipoprotein (Ox-LDL)is implicated in the pathogenesis of atherosclerosis. Circulating oxidation-specific epitopes on plasma Ox-LDL has been linked with coronary artery disease, but its determinants and its association with early development of atherosclerosis in familial combined hyperlipidemia (FCHL) has not been very well studied. This study aimed to investigate the determinants of the circulating Ox-LDL and the association between Ox-LDL and carotid intima-media thickness (IMT) in asymptomatic members of FCHL families. METHODS AND RESULTS: Ox-LDL, susceptibility of LDL to oxidation in vitro, plasma 8-isoprostane and antioxidants, lipids and lipoproteins, LDL particle size, and carotid IMT were measured in 150 asymptomatic FCHL family members. Affected FCHL family members had reduced LDL particle size and lag time for LDL oxidation, increased plasma levels of Ox-LDL, increased plasma urate and alpha-tocopherol, and a trend for the increase of 8-isoprostane as compared with nonaffected FCHL. Ox-LDL was independently associated with serum LDL cholesterol, apoB, and 8-isoprostane in multivariate analysis but only univariately correlated with LDL particle size and lag time for LDL oxidation. In addition, Ox-LDL was significantly associated with carotid mean IMT independently of other clinical and biochemical variables in a multivariate model. CONCLUSIONS: Serum LDL cholesterol, apoB levels, and 8-isoprostane were the most important determinants of Ox-LDL. Ox-LDL is independently associated with carotid IMT in asymptomatic FCHL family members and can be used as a marker of early atherosclerosis in FCHL. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/15205217/Circulating_oxidized_low_density_lipoprotein_and_its_association_with_carotid_intima_media_thickness_in_asymptomatic_members_of_familial_combined_hyperlipidemia_families_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.ATV.0000135982.60383.48?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -