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Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease.
Arterioscler Thromb Vasc Biol 2004; 24(8):1529-34AT

Abstract

OBJECTIVE

Activated inflammation and activated blood coagulation are believed to increase the risk of coronary thrombosis and are related. We therefore compared plasma IL-6 (a key cytokine in the inflammatory process), fibrin D-dimer (a marker of fibrin turnover), and coagulation factors VII and XIIa (initiators of extrinsic and intrinsic blood coagulation, respectively) as predictors of coronary risk in the West of Scotland Coronary Prevention Study of pravastatin in men with hypercholesterolemia.

METHODS AND RESULTS

485 men who had had a coronary event (nonfatal myocardial infarction, death from coronary heart disease, or revascularization) were matched for age and smoking status with 934 controls. Baseline IL-6 and D-dimer were strong univariate predictors of coronary risk (relative risk in the highest quintile approximately twice that in the lowest quintile) and were associated with each other and with C-reactive protein. On multivariate analyses, D-dimer retained a significant association with coronary risk (relative risk, 1.86; 95% CI, 1.24 to 2.80), whereas IL-6 (1.47; 0.95 to 2.28) and C-reactive protein (1.33; 0.85 to 2.08) did not. Neither factor VII nor factor XIIa antigens were predictors of coronary events.

CONCLUSIONS

Fibrin D-dimer may be a stronger predictor of coronary risk than inflammatory markers, perhaps through its ability to stimulate monocyte release of IL-6.

Authors+Show Affiliations

Department of Medicine, University of Glasgow, Glasgow, UK. gdl1j@clinmed.gla.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15205218

Citation

Lowe, Gordon D O., et al. "Interleukin-6, Fibrin D-dimer, and Coagulation Factors VII and XIIa in Prediction of Coronary Heart Disease." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 8, 2004, pp. 1529-34.
Lowe GD, Rumley A, McMahon AD, et al. Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease. Arterioscler Thromb Vasc Biol. 2004;24(8):1529-34.
Lowe, G. D., Rumley, A., McMahon, A. D., Ford, I., O'Reilly, D. S., & Packard, C. J. (2004). Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(8), pp. 1529-34.
Lowe GD, et al. Interleukin-6, Fibrin D-dimer, and Coagulation Factors VII and XIIa in Prediction of Coronary Heart Disease. Arterioscler Thromb Vasc Biol. 2004;24(8):1529-34. PubMed PMID: 15205218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease. AU - Lowe,Gordon D O, AU - Rumley,Ann, AU - McMahon,Alex D, AU - Ford,Ian, AU - O'Reilly,Denis St J, AU - Packard,Christopher J, AU - ,, Y1 - 2004/06/17/ PY - 2004/6/19/pubmed PY - 2005/2/11/medline PY - 2004/6/19/entrez SP - 1529 EP - 34 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 24 IS - 8 N2 - OBJECTIVE: Activated inflammation and activated blood coagulation are believed to increase the risk of coronary thrombosis and are related. We therefore compared plasma IL-6 (a key cytokine in the inflammatory process), fibrin D-dimer (a marker of fibrin turnover), and coagulation factors VII and XIIa (initiators of extrinsic and intrinsic blood coagulation, respectively) as predictors of coronary risk in the West of Scotland Coronary Prevention Study of pravastatin in men with hypercholesterolemia. METHODS AND RESULTS: 485 men who had had a coronary event (nonfatal myocardial infarction, death from coronary heart disease, or revascularization) were matched for age and smoking status with 934 controls. Baseline IL-6 and D-dimer were strong univariate predictors of coronary risk (relative risk in the highest quintile approximately twice that in the lowest quintile) and were associated with each other and with C-reactive protein. On multivariate analyses, D-dimer retained a significant association with coronary risk (relative risk, 1.86; 95% CI, 1.24 to 2.80), whereas IL-6 (1.47; 0.95 to 2.28) and C-reactive protein (1.33; 0.85 to 2.08) did not. Neither factor VII nor factor XIIa antigens were predictors of coronary events. CONCLUSIONS: Fibrin D-dimer may be a stronger predictor of coronary risk than inflammatory markers, perhaps through its ability to stimulate monocyte release of IL-6. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/15205218/Interleukin_6_fibrin_D_dimer_and_coagulation_factors_VII_and_XIIa_in_prediction_of_coronary_heart_disease_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.ATV.0000135995.39488.6c?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -