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Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in community dwelling postmenopausal Hungarian women.
Osteoporos Int. 2004 Jun; 15(6):447-51.OI

Abstract

Hypovitaminosis D can result in low bone mass. The prevalence of hypovitaminosis D has public health implications, especially where data are lacking. Since diet and sunlight are the two souces of vitamin D, the results obtained in one geographical region may not be universally applicable. The aim of this study is to characterize the prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in community dwelling postmenopausal Hungarian women. We determined serum levels of 25-hydroxyvitamin D (25-OH-D), PTH, osteocalcin (OC), degradation products of C-terminal telopeptides of type-I collagen (CTx), dietary calcium intake and BMD at L2-L4 lumbar spine (LS) and femur neck (FN) in 319 randomly selected ambulatory postmenopausal women. The prevalence of hypovitaminosis D (serum 25-OH-D< or =50 nmol/l) was 56.7%. On comparing patients with normal and low 25-OH-D, a significant difference was found in age (61.6+/-8.5 years versus 67.3+/-9.9 years; P<0.001), PTH (3.9+/-1.9 pmol/l versus 4.3+/-2.7 pmol/l; P<0.05), FN BMD (0.802+/-0.123 g/cm(2) versus 0.744+/-0.125 g/cm(2); P<0.001) and dietary calcium intake (714.4+/-199.4 g/day versus 607.9+/-233 g/day; P<0.001). Osteoporotic patients had a significantly lower 25-OH-D (37.6+/-19.8 nmol/l versus 56.4+/-24 nmol/l; P<0.001) and dietary calcium intake (519.2+/-244.5 mg/day versus 718.2+/-164.3 mg/day; P<0.001). After controlling for all other variables, 25-OH-D was found to be significantly associated with age, the average hours of sunshine in the 3 months prior to 25-OH-D level determination and dietary calcium intake (r(2)=0.190; P<0.001). For FN BMD, significant independent predictors were age, body mass index, 25-OH-D and dietary calcium intake (r(2)=0.435; P<0.001). The prevalence of hypovitaminosis D during spring, summer, autumn and winter was 71%, 46.3%, 49.4% and 56.7%, respectively. There was significant seasonal variation in 25-OH-D, PTH, OC, calcium intake and FN BMD. There is a high prevalence of hypovitaminosis D in healthy postmenopausal Hungarian women, and FN BMD is associated with serum 25-OH-D and dietary calcium intake.

Authors+Show Affiliations

Regional Osteoporosis Center, Department of Obstetrics and Gynecology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt. 98, PO Box 37, 4012 Debrecen, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15205715

Citation

Bhattoa, H P., et al. "Prevalence and Seasonal Variation of Hypovitaminosis D and Its Relationship to Bone Metabolism in Community Dwelling Postmenopausal Hungarian Women." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 15, no. 6, 2004, pp. 447-51.
Bhattoa HP, Bettembuk P, Ganacharya S, et al. Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in community dwelling postmenopausal Hungarian women. Osteoporos Int. 2004;15(6):447-51.
Bhattoa, H. P., Bettembuk, P., Ganacharya, S., & Balogh, A. (2004). Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in community dwelling postmenopausal Hungarian women. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 15(6), 447-51.
Bhattoa HP, et al. Prevalence and Seasonal Variation of Hypovitaminosis D and Its Relationship to Bone Metabolism in Community Dwelling Postmenopausal Hungarian Women. Osteoporos Int. 2004;15(6):447-51. PubMed PMID: 15205715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in community dwelling postmenopausal Hungarian women. AU - Bhattoa,H P, AU - Bettembuk,P, AU - Ganacharya,S, AU - Balogh,A, Y1 - 2003/12/23/ PY - 2003/09/01/received PY - 2003/11/21/accepted PY - 2004/6/19/pubmed PY - 2004/8/21/medline PY - 2004/6/19/entrez SP - 447 EP - 51 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 15 IS - 6 N2 - Hypovitaminosis D can result in low bone mass. The prevalence of hypovitaminosis D has public health implications, especially where data are lacking. Since diet and sunlight are the two souces of vitamin D, the results obtained in one geographical region may not be universally applicable. The aim of this study is to characterize the prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in community dwelling postmenopausal Hungarian women. We determined serum levels of 25-hydroxyvitamin D (25-OH-D), PTH, osteocalcin (OC), degradation products of C-terminal telopeptides of type-I collagen (CTx), dietary calcium intake and BMD at L2-L4 lumbar spine (LS) and femur neck (FN) in 319 randomly selected ambulatory postmenopausal women. The prevalence of hypovitaminosis D (serum 25-OH-D< or =50 nmol/l) was 56.7%. On comparing patients with normal and low 25-OH-D, a significant difference was found in age (61.6+/-8.5 years versus 67.3+/-9.9 years; P<0.001), PTH (3.9+/-1.9 pmol/l versus 4.3+/-2.7 pmol/l; P<0.05), FN BMD (0.802+/-0.123 g/cm(2) versus 0.744+/-0.125 g/cm(2); P<0.001) and dietary calcium intake (714.4+/-199.4 g/day versus 607.9+/-233 g/day; P<0.001). Osteoporotic patients had a significantly lower 25-OH-D (37.6+/-19.8 nmol/l versus 56.4+/-24 nmol/l; P<0.001) and dietary calcium intake (519.2+/-244.5 mg/day versus 718.2+/-164.3 mg/day; P<0.001). After controlling for all other variables, 25-OH-D was found to be significantly associated with age, the average hours of sunshine in the 3 months prior to 25-OH-D level determination and dietary calcium intake (r(2)=0.190; P<0.001). For FN BMD, significant independent predictors were age, body mass index, 25-OH-D and dietary calcium intake (r(2)=0.435; P<0.001). The prevalence of hypovitaminosis D during spring, summer, autumn and winter was 71%, 46.3%, 49.4% and 56.7%, respectively. There was significant seasonal variation in 25-OH-D, PTH, OC, calcium intake and FN BMD. There is a high prevalence of hypovitaminosis D in healthy postmenopausal Hungarian women, and FN BMD is associated with serum 25-OH-D and dietary calcium intake. SN - 0937-941X UR - https://www.unboundmedicine.com/medline/citation/15205715/Prevalence_and_seasonal_variation_of_hypovitaminosis_D_and_its_relationship_to_bone_metabolism_in_community_dwelling_postmenopausal_Hungarian_women_ L2 - https://dx.doi.org/10.1007/s00198-003-1566-1 DB - PRIME DP - Unbound Medicine ER -