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Melatonin: detoxification of oxygen and nitrogen-based toxic reactants.
Adv Exp Med Biol. 2003; 527:539-48.AE

Abstract

In the last decade, melatonin has been found to be highly protective against damage to macromolecules resulting from oxygen and nitrogen-based reactants. Considering this, numerous studies have examined the mechanisms whereby this indoleamine directly detoxifies these damaging agents. The evidence is compelling that melatonin scavenges several oxygen-derived reactive agents including the hydroxyl radical (OH), hydrogen peroxide (H2O2), singlet oxygen (1O2) and hypochlorous acid (HOCl). Additionally, melatonin reportedly reacts with nitric oxide (NO), the peroxynitrite anion (ONOO-) and/or peroxynitrous acid (ONOOH) to detoxify them. In some cases the products that are formed as a consequence of melatonin's scavenging actions have been identified. Whereas the ability of melatonin to neutralize these toxic agents likely accounts, in part, for the antioxidant activity of melatonin, it is not the only means by which melatonin serves to protect molecules from oxygen and nitrogen-based reactive metabolites.

Authors+Show Affiliations

Reiter RJ
Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA. reiter@uthscsa.edu
Tan DX
No affiliation info available
Manchester LC
No affiliation info available
Lopez-Burillo S
No affiliation info available
Sainz RM
No affiliation info available
Mayo JC
No affiliation info available

MeSH

AnimalsAntioxidantsDNA DamageFree Radical ScavengersHumansIn Vitro TechniquesMelatoninReactive Nitrogen SpeciesReactive Oxygen Species

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15206772

Citation

Reiter, Russel J., et al. "Melatonin: Detoxification of Oxygen and Nitrogen-based Toxic Reactants." Advances in Experimental Medicine and Biology, vol. 527, 2003, pp. 539-48.
Reiter RJ, Tan DX, Manchester LC, et al. Melatonin: detoxification of oxygen and nitrogen-based toxic reactants. Adv Exp Med Biol. 2003;527:539-48.
Reiter, R. J., Tan, D. X., Manchester, L. C., Lopez-Burillo, S., Sainz, R. M., & Mayo, J. C. (2003). Melatonin: detoxification of oxygen and nitrogen-based toxic reactants. Advances in Experimental Medicine and Biology, 527, 539-48.
Reiter RJ, et al. Melatonin: Detoxification of Oxygen and Nitrogen-based Toxic Reactants. Adv Exp Med Biol. 2003;527:539-48. PubMed PMID: 15206772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melatonin: detoxification of oxygen and nitrogen-based toxic reactants. AU - Reiter,Russel J, AU - Tan,Dun-Xian, AU - Manchester,Lucien C, AU - Lopez-Burillo,Silvia, AU - Sainz,Rosa M, AU - Mayo,Juan C, PY - 2004/6/23/pubmed PY - 2004/9/3/medline PY - 2004/6/23/entrez SP - 539 EP - 48 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 527 N2 - In the last decade, melatonin has been found to be highly protective against damage to macromolecules resulting from oxygen and nitrogen-based reactants. Considering this, numerous studies have examined the mechanisms whereby this indoleamine directly detoxifies these damaging agents. The evidence is compelling that melatonin scavenges several oxygen-derived reactive agents including the hydroxyl radical (OH), hydrogen peroxide (H2O2), singlet oxygen (1O2) and hypochlorous acid (HOCl). Additionally, melatonin reportedly reacts with nitric oxide (NO), the peroxynitrite anion (ONOO-) and/or peroxynitrous acid (ONOOH) to detoxify them. In some cases the products that are formed as a consequence of melatonin's scavenging actions have been identified. Whereas the ability of melatonin to neutralize these toxic agents likely accounts, in part, for the antioxidant activity of melatonin, it is not the only means by which melatonin serves to protect molecules from oxygen and nitrogen-based reactive metabolites. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/15206772/Melatonin:_detoxification_of_oxygen_and_nitrogen_based_toxic_reactants_ DB - PRIME DP - Unbound Medicine ER -